Investigating the role of the brain-derived neurotrophic factor Val66Met polymorphism in repetitive mild traumatic brain injury outcomes in rats

Investigating the role of the brain-derived neurotrophic factor Val66Met polymorphism in repetitive mild traumatic brain injury outcomes in rats

Abstract Background Mild traumatic brain injury (mTBI) poses a significant public health concern, particularly regarding repetitive injury, with outcomes ranging from acute neurobehavioral deficits to long-term impairments. While demographic factors like age and sex influence outcomes, the understan...

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Bibliographic Details
Main Authors: Lauren P. Giesler, William T. O’Brien, Jesse Bain, Gershon Spitz, Emily J. Jaehne, Maarten van den Buuse, Sandy R. Shultz, Richelle Mychasiuk, Stuart J. McDonald
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Behavioral and Brain Functions
Subjects:
Concussion
Val66Met
Biomarker
Microglia
Neurofilament light
Behavior
Online Access:https://doi.org/10.1186/s12993-025-00270-5
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