Inhibitory effect of dimethyl sulfoxide on the development of gastrointestinal nematode larvae in the larval development test

Inhibitory effect of dimethyl sulfoxide on the development of gastrointestinal nematode larvae in the larval development test

Dimethyl sulfoxide (DMSO) is an amphipathic solvent for molecules in in vitro tests for detection of anthelmintic resistance of gastrointestinal nematodes (GIN). It has been shown to have a concentration-dependent detrimental effect on Caenorhabditis elegans, a free-living nematode. If GIN are likew...

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Main Authors: Mickiewicz Marcin, Nowek Zofia, Czopowicz Michał, Moroz-Fik Agata, Potărniche Adrian-Valentin, Biernacka Kinga, Szaluś-Jordanow Olga, Górski Paweł, Antonopoulos Alistair, Markowska-Daniel Iwona, Várady Marián, Kaba Jarosław
Format: Article
Language:English
Published: Sciendo 2025-03-01
Series:Journal of Veterinary Research
Subjects:
anthelmintic resistance
dmso
five-parameter logistic curve
inhibitory concentration
trichostrongylidae
Online Access:https://doi.org/10.2478/jvetres-2025-0016
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Summary:Dimethyl sulfoxide (DMSO) is an amphipathic solvent for molecules in in vitro tests for detection of anthelmintic resistance of gastrointestinal nematodes (GIN). It has been shown to have a concentration-dependent detrimental effect on Caenorhabditis elegans, a free-living nematode. If GIN are likewise affected, using DMSO in egg-hatch test and larval development test (LDT) may confound their results. Therefore, the DMSO concentration was determined at which it exerted an inhibitory effect on GIN larval development to the third stage.
ISSN:2450-8608

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