NFIA-dependent upregulation of SMC4 promotes metastasis and metabolic reprogramming in glioma

NFIA-dependent upregulation of SMC4 promotes metastasis and metabolic reprogramming in glioma

BackgroundGliomas, particularly glioblastoma, are aggressive brain tumors with poor prognosis and unmet therapeutic needs. Structural maintenance of chromosomes 4 (SMC4), a core component of the condensin complex, is dysregulated in multiple cancers, but its role in glioma metabolism and metastasis...

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Bibliographic Details
Main Authors: Guoyin Li, Yukui Zhao, Yubo He, Zhaoqiang Qian, Xiaoyan Li, Zewen Song, Zhiqiang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
glioma
NFIA/SMC4 axis
metastasis
metabolic reprogramming
SRRs
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1624370/full
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