A cell-based Papain-like Protease (PLpro) activity assay for rapid detection of active SARS-CoV-2 infections and antivirals.

A cell-based Papain-like Protease (PLpro) activity assay for rapid detection of active SARS-CoV-2 infections and antivirals.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants are a continuous threat to human life. An urgent need remains for simple and fast tests that reliably detect active infections with SARS-CoV-2 and its variants in the early stage of infection. Here we introduce a simple an...

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Main Authors: Anahi G Jimenez-Campos, Lucas I Maestas, Nileena Velappan, Brian Beck, Chunyan Ye, Keith Wernsing, Yaniksa Mata-Solis, William J Bruno, Silas C Bussmann, Steven Bradfute, Justin T Baca, Frauke H Rininsland
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0309305
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