Towards the elimination of infectious HPV: exploiting CRISPR/Cas innovations
HPV has been conclusively associated with various human malignancies, making the development of prevention and treatment strategies for HPV-induced diseases a high priority. Currently, primary prevention methods include HPV immunization and routine screening, which significantly reduce the risk of H...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1627668/full |
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| author | Wei Liu Yingyan Jiang Cheng Wang Min Wang Wei Zhang Haiying Ren Shiyan Xu Jinjing Qin Pan Liu Lianhai Jin Donghai Zhao |
| author_facet | Wei Liu Yingyan Jiang Cheng Wang Min Wang Wei Zhang Haiying Ren Shiyan Xu Jinjing Qin Pan Liu Lianhai Jin Donghai Zhao |
| author_sort | Wei Liu |
| collection | DOAJ |
| description | HPV has been conclusively associated with various human malignancies, making the development of prevention and treatment strategies for HPV-induced diseases a high priority. Currently, primary prevention methods include HPV immunization and routine screening, which significantly reduce the risk of HPV transmission. However, for patients diagnosed with invasive, advanced, or recurrent malignancies, non-virus-specific therapies frequently lead to drug resistance and adverse effects, resulting in minimal improvement in treatment efficacy for numerous patients. Viral genome-targeting therapy is emerging as a promising avenue for the future management of HPV infections. With the rapid advancement of genetic modification technologies, the CRISPR/Cas system has demonstrated significant potential in treating viral infections. Its ability to selectively target and edit viral genomes for elimination positions it as a highly effective approach for combating HPV. This review will explore the functions and applications of the CRISPR/Cas system as an innovative therapy for HPV. We will illustrate the prospective efficacy of CRISPR/Cas as a groundbreaking and promising cure for HPV infections, while also addressing the opportunities and challenges associated with this novel approach. |
| format | Article |
| id | doaj-art-8de3ce7e19fa41b59c3f2a0e5d142a22 |
| institution | DOAJ |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-8de3ce7e19fa41b59c3f2a0e5d142a222025-08-20T03:18:20ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-08-011510.3389/fcimb.2025.16276681627668Towards the elimination of infectious HPV: exploiting CRISPR/Cas innovationsWei Liu0Yingyan Jiang1Cheng Wang2Min Wang3Wei Zhang4Haiying Ren5Shiyan Xu6Jinjing Qin7Pan Liu8Lianhai Jin9Donghai Zhao10College of Laboratory Medicine, Jilin Medical University, Jilin, ChinaDepartment of Obstetrics and Gynecology, Affiliated hospital of Jilin medical university, Jilin, ChinaCollege of Basic Medicine, Jilin Medical University, Jilin, ChinaDepartment of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, ChinaLow Pressure and Low Oxygen Environment and Health Intervention Innovation Center, Jilin Medical University, Jilin, ChinaPsychiatric Research Unit III, Jilin Sixth People’s Hospital, Jilin, ChinaCollege of Laboratory Medicine, Jilin Medical University, Jilin, ChinaCollege of Laboratory Medicine, Jilin Medical University, Jilin, ChinaCollege of Laboratory Medicine, Jilin Medical University, Jilin, ChinaLow Pressure and Low Oxygen Environment and Health Intervention Innovation Center, Jilin Medical University, Jilin, ChinaCollege of Basic Medicine, Jilin Medical University, Jilin, ChinaHPV has been conclusively associated with various human malignancies, making the development of prevention and treatment strategies for HPV-induced diseases a high priority. Currently, primary prevention methods include HPV immunization and routine screening, which significantly reduce the risk of HPV transmission. However, for patients diagnosed with invasive, advanced, or recurrent malignancies, non-virus-specific therapies frequently lead to drug resistance and adverse effects, resulting in minimal improvement in treatment efficacy for numerous patients. Viral genome-targeting therapy is emerging as a promising avenue for the future management of HPV infections. With the rapid advancement of genetic modification technologies, the CRISPR/Cas system has demonstrated significant potential in treating viral infections. Its ability to selectively target and edit viral genomes for elimination positions it as a highly effective approach for combating HPV. This review will explore the functions and applications of the CRISPR/Cas system as an innovative therapy for HPV. We will illustrate the prospective efficacy of CRISPR/Cas as a groundbreaking and promising cure for HPV infections, while also addressing the opportunities and challenges associated with this novel approach.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1627668/fullHPVCRISPR/Casgene editingviral genome targeting therapyHPV-associated diseases |
| spellingShingle | Wei Liu Yingyan Jiang Cheng Wang Min Wang Wei Zhang Haiying Ren Shiyan Xu Jinjing Qin Pan Liu Lianhai Jin Donghai Zhao Towards the elimination of infectious HPV: exploiting CRISPR/Cas innovations Frontiers in Cellular and Infection Microbiology HPV CRISPR/Cas gene editing viral genome targeting therapy HPV-associated diseases |
| title | Towards the elimination of infectious HPV: exploiting CRISPR/Cas innovations |
| title_full | Towards the elimination of infectious HPV: exploiting CRISPR/Cas innovations |
| title_fullStr | Towards the elimination of infectious HPV: exploiting CRISPR/Cas innovations |
| title_full_unstemmed | Towards the elimination of infectious HPV: exploiting CRISPR/Cas innovations |
| title_short | Towards the elimination of infectious HPV: exploiting CRISPR/Cas innovations |
| title_sort | towards the elimination of infectious hpv exploiting crispr cas innovations |
| topic | HPV CRISPR/Cas gene editing viral genome targeting therapy HPV-associated diseases |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1627668/full |
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