Digitoflavone Ameliorates Acute Lung Injury via Disturbing the Formation of Functional Stimulator of Interferon Genes Signalosome

Digitoflavone Ameliorates Acute Lung Injury via Disturbing the Formation of Functional Stimulator of Interferon Genes Signalosome

Objective: The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon (IFN) genes (STING) signaling pathway has been implicated in the initiation and maintenance of a variety of inflammatory diseases. Thus, the search for modulators of the cGAS-STING signaling pathway is likely to contribute to the...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jun-Jie Li, Qing Yao, Ming Dong, Yan Wang, Ye Xiu, Zhi-Xin Wu, Xiao-Mei Zhao, Yin-Kang Wang, Xian-Ling Wang, Yu-Xuan Tian, Xiao-He Xiao, Zhao-Fang Bai
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2025-04-01
Series:	World Journal of Traditional Chinese Medicine
Subjects:	acute lung injury cyclic gmp-amp synthase-stimulator of interferon genes digitoflavone interferon regulatory factor 3 stimulator of interferon genes signalosome type i interferon
Online Access:	https://journals.lww.com/10.4103/wjtcm.wjtcm_100_24
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Advances in the prerequisite and consequence of STING downstream signalosomes
by: Lu Xinliang, et al.
Published: (2024-10-01)

The expression of interferon-stimulated genes (interferon “signature”) in patients with rheumatoid arthritis (Preliminary results)
by: A. S. Avdeeva, et al.
Published: (2021-01-01)

Deletion of the Human Cytomegalovirus US2 to US11 Gene Family Members Impairs the Type-I Interferon Response
by: Inessa Penner, et al.
Published: (2025-03-01)

Editorial: Modulation of pro-inflammatory signaling by interferons
by: René Huber, et al.
Published: (2025-07-01)

Novel Modifications and Delivery Modes of Cyclic Dinucleotides for STING Activation in Cancer Treatment
by: Lu Y, et al.
Published: (2025-01-01)

Expression of interferon-stimulated genes in patients with rheumatoid arthritis on anti-B-cell therapy (preliminary results)
by: A. S. Avdeeva, et al.
Published: (2021-10-01)

Diffuse traumatic brain injury induced stimulator of interferons (STING) signaling in microglia drives cortical neuroinflammation, neuronal dysfunction, and impaired cognition
by: Jonathan M. Packer, et al.
Published: (2025-04-01)

Avian interferon regulatory factor (IRF) family reunion: IRF3 and IRF9 found
by: Lenka Ungrová, et al.
Published: (2025-07-01)

Nonproductive exposure of PBMCs to SARS‐CoV‐2 induces cell‐intrinsic innate immune responses
by: Julia Kazmierski, et al.
Published: (2022-08-01)

The intestinal interferon system and specialized enterocytes as putative drivers of HIV latency
by: Rachel L. Creighton, et al.
Published: (2025-05-01)

Interferon-stimulated gene subtypes as key indicators of immune landscape and survival outcomes in ovarian cancer
by: Wanjun Luo, et al.
Published: (2024-12-01)

Spermidine reduces ISGylation and enhances ISG15–USP18 interaction
by: Haruka Etori, et al.
Published: (2025-05-01)

Phase transition of WTAP regulates m6A modification of interferon-stimulated genes
by: Sihui Cai, et al.
Published: (2025-05-01)

The concerted actions of microRNA-29a and interferon-β modulate complete Freund's adjuvant-induced inflammatory pain by regulating the expression of type 1 interferon receptor, interferon-stimulated gene 15, and p-extracellular signal-regulated kinase
by: Chien-Cheng Liu, et al.
Published: (2025-03-01)

Chasing Virus Replication and Infection: PAMP-PRR Interaction Drives Type I Interferon Production, Which in Turn Activates ISG Expression and ISGylation
by: Imaan Muhammad, et al.
Published: (2025-04-01)

Ethanol Disrupts the Protective Crosstalk Between Macrophages and HBV-Infected Hepatocytes
by: Murali Ganesan, et al.
Published: (2025-01-01)

Interferon status at the women with recurrent genital herpes in combined liposomal RNA treatment
by: A. Sh. Makhmutkhodzhayev, et al.
Published: (2012-06-01)

The effectiveness of Interferon-Ophthalmo, an antiviral and immunotropic drug, in the treatment of adenoviral ophthalmic infections
by: E. V. Yani, et al.
Published: (2023-03-01)

Clinical significance of interferon status in patients with systemic lupus erythematosus. Preliminary data
by: T. A. Panafidina, et al.
Published: (2025-03-01)

Genetic Polymorphism of Interferon-Gamma +874T/A as a Risk Factor for Pulmonary Tuberculosis in Cirebon, Indonesia
by: Allain Umadela Deuxawalu Kiteswara, et al.
Published: (2024-11-01)

CSF3 enhances the innate immune responses to ALV-J infections via NF-κB and interferon pathways
by: Junliang Xia, et al.
Published: (2025-11-01)

Identification of a prognostic signature consisting of three macrophage-related genes for glioblastoma based on bulk and single-cell transcriptomes analyses
by: Qiyan Wu, et al.
Published: (2025-12-01)

ADMINISTRATION CRITERIA FOR INTERFERON-BASED DRUGS AND ITS INDUCERS IN ACUTE RESPIRATORY INFECTIONS IN CHILDREN
by: E. G. Golovacheva, et al.
Published: (2014-07-01)

ACTIVATION OF SYNTHESIS OF ENDOGENOUS INTERFERON (REVIEW)
by: V. V. Poloskov, et al.
Published: (2019-01-01)

Role of interferon regulatory factors in predicting the prognosis of Crimean-Congo hemorrhagic fever
by: Öksüz Caner, et al.
Published: (2024-12-01)

Interferon Status and Choice of Interferons Inducers in Frequently Ill Children
by: M. S. Savenkovа, et al.
Published: (2016-06-01)

Association of interferon regulatory factor 8 dysregulation with dry eye in Sjögren’s syndrome
by: Jiao Wang, et al.
Published: (2025-08-01)

Bioinformatic analysis and experimental verification reveal expansion of monocyte subsets with an interferon signature in systemic lupus erythematosus patients
by: Jimin Zhang, et al.
Published: (2025-04-01)

DNA Methylation Patterns of Interferon Gamma Gene Promoter and Serum Level in Pulmonary Tuberculosis: Their Role in Prognosis
by: Zayr et al.
Published: (2019-03-01)

Portrait of a patient with systemic lupus erythematosus for the prescription of the type I interferon inhibitor anifrolumab
by: T. M. Reshetnyak, et al.
Published: (2023-12-01)

The role of cytokines and interferons during pregnancy
by: T. Е. Belokrinitskaya, et al.
Published: (2024-09-01)

Interferons in Ophthalmology Current Status and Advancing Trends
by: Shiva Prasad Gantyala, et al.
Published: (2013-04-01)

Efficacy and safety of the type I interferon receptor inhibitor anifrolumab in patients with systemic lupus erythematosus (results of a 6-month study)
by: T. M. Reshetnyak, et al.
Published: (2024-04-01)

Rapid achievement of low disease activity during the use of a type I interferon inhibitor in a patient with torpid systemic lupus erythematosus (case report)
by: A. A. Baranov, et al.
Published: (2024-06-01)

The role of inflammation in wasp sting-induced acute kidney injury
by: Xia Ling-ya, et al.
Published: (2025-05-01)

Viperin: A Multifunctional Protein in Antiviral Immunity and Disease Pathogenesis
by: Qun Cui, et al.
Published: (2025-05-01)

The first trimester human placenta responds to Zika virus infection inducing an interferon (IFN) and antiviral interferon stimulated gene (ISG) response
by: Kylie H. Van der Hoek, et al.
Published: (2025-04-01)

Results of using interferon α-2b in combination with vitamins E and C in the treatment of urogenital infections in pregnant women
by: T. A. Ruzhentsova, et al.
Published: (2021-06-01)

Evaluation of the effectiveness and safety of interferon alpha-2b ointment and gel for prevention of acute respiratory infections in organized groups
by: K. V. Kozlov, et al.
Published: (2024-04-01)

RETRACTED: The Expression of ephrinA1/ephA2 Receptor Increases in Chronic Rhinosinusitis and ephrinA1/ephA2 Signaling Affects Rhinovirus-Induced Innate Immunity in Human Sinonasal Epithelial Cells
by: Sang Hag Lee, et al.
Published: (2021-12-01)