Gene-Expression-Guided Selection of Candidate Loci and Molecular Phenotype Analyses Enhance Genetic Discovery in Systemic Lupus Erythematosus

Gene-Expression-Guided Selection of Candidate Loci and Molecular Phenotype Analyses Enhance Genetic Discovery in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disorder characterized by differences in autoantibody profiles, serum cytokines, and clinical manifestations. We have previously conducted a case-case genome-wide association study (GWAS) of SLE patients to detect associations w...

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Main Authors: Yelena Koldobskaya, Kichul Ko, Akaash A. Kumar, Sandra Agik, Jasmine Arrington, Silvia N. Kariuki, Beverly S. Franek, Marissa Kumabe, Tammy O. Utset, Meenakshi Jolly, Andrew D. Skol, Timothy B. Niewold
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1155/2012/682018
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