Potential pharmacological effect of Quercetin Phytosome™ in the management of hyperuricemia: results from real-life clinical studies
BackgroundHyperuricemia is associated with several metabolic and cardiovascular disorders, and traditional treatments, such as xanthine oxidase (XO) inhibitors, often have limitations, such as severe hypersensitivity reactions or ineffectiveness in achieving target serum urate levels in some patient...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1519459/full |
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| author | Francesco Di Pierro Francesco Di Pierro Francesco Di Pierro Fazle Rabbani Meherullah Tareen Roohi Nigar Amjad Khan Nicola Zerbinati Maria L. Tanda Massimiliano Cazzaniga Alexander Bertuccioli Alexander Bertuccioli Paolo Falasca Gabriele Damiani Nicola Villanova |
| author_facet | Francesco Di Pierro Francesco Di Pierro Francesco Di Pierro Fazle Rabbani Meherullah Tareen Roohi Nigar Amjad Khan Nicola Zerbinati Maria L. Tanda Massimiliano Cazzaniga Alexander Bertuccioli Alexander Bertuccioli Paolo Falasca Gabriele Damiani Nicola Villanova |
| author_sort | Francesco Di Pierro |
| collection | DOAJ |
| description | BackgroundHyperuricemia is associated with several metabolic and cardiovascular disorders, and traditional treatments, such as xanthine oxidase (XO) inhibitors, often have limitations, such as severe hypersensitivity reactions or ineffectiveness in achieving target serum urate levels in some patients. Quercetin, a naturally occurring flavonoid, has shown potential as a hypouricemic agent through XO inhibition.ObjectiveThis study aims to evaluate the potential hypouricemic effect of Quercetin Phytosome™ (QP) supplementation across three cohort studies involving healthy adults with various metabolic health profiles, exploring its potential as a safe, effective intervention for hyperuricemia.MethodsClinical data collected in various clinics in Italy between September 2021 and April 2024 under real-life clinical settings from three distinct cohort studies, were analyzed. Cohort 1 consisted of 164 healthy participants (87 QP-treated, 77 probiotic Streptococcus salivarius (S. salivarius) K12-treated) who were monitored for 90 days. Cohort 2 included 22 mildly hyperuricemic adults with metabolic disorders receiving QP, while Cohort 3 comprised 64 obese adults with hypercholesterolemia, further divided into moderately hyperuricemic QP-treated group (n = 20), a moderately hyperuricemic Berberine Phytosome™ and monacolins (BM)-treated group (n = 22), and a normouricemic BM-treated group (n = 22). QP was administered at 400 mg of quercetin daily in all cohorts. Primary endpoints were reductions in serum uric acid levels, while secondary outcomes included effects on lipid profile, glycemia, liver enzymes, and treatment tolerability.ResultsIn Cohort 1, QP significantly reduced uric acid levels by 15.2% in males and 13.8% in females, with no significant changes observed in the probiotic group. Cohort 2 showed a significant 13.1% reduction in uric acid (p < 0.01) and a concurrent 10.2% reduction in triglycerides (p < 0.05). In Cohort 3, QP led to a 13.7% decrease in uric acid and a 20.8% reduction in triglycerides (p < 0.01), with no significant uric acid changes in the BM-treated group. QP was well tolerated across all cohorts, with minimal, transient side effects.ConclusionQP supplementation demonstrates a significant hypouricemic effect. Additionally, triglyceride-lowering benefits were evident, particularly in metabolically compromised individuals (Cohorts 2 and 3), where these effects were statistically significant. With high tolerability, these findings highlight Quercetin Phytosome™'s potential as a safe adjunctive therapy for hyperuricemia management, meriting further investigation in larger, randomized trials to confirm its efficacy and safety.Clinical Trial Registrationclinicaltrials.gov, identifier NCT06652035. |
| format | Article |
| id | doaj-art-8de0580de96e4a15bd42999ab4531362 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-8de0580de96e4a15bd42999ab45313622025-02-07T15:49:33ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-02-011210.3389/fnut.2025.15194591519459Potential pharmacological effect of Quercetin Phytosome™ in the management of hyperuricemia: results from real-life clinical studiesFrancesco Di Pierro0Francesco Di Pierro1Francesco Di Pierro2Fazle Rabbani3Meherullah Tareen4Roohi Nigar5Amjad Khan6Nicola Zerbinati7Maria L. Tanda8Massimiliano Cazzaniga9Alexander Bertuccioli10Alexander Bertuccioli11Paolo Falasca12Gabriele Damiani13Nicola Villanova14Microbiota International Clinical Society, Torino, ItalyDepartment of Scientific and Research, Velleja Research, Milano, ItalyDepartment of Medicine and Technological Innovation, University of Insubria, Varese, ItalyDepartment of Psychiatry, Lady Reading Hospital, Peshawar, PakistanDepartment of Oncology, Bolan Medical College Hospital, Quetta, PakistanDepartment of Obstetrics and Gynecology, Bilawal Medical College, Jamshoro, PakistanDepartment of Oncology, University of Oxford, Oxford, United KingdomDepartment of Medicine and Technological Innovation, University of Insubria, Varese, ItalyEndocrine Unit, Department of Medicine and Surgery, University of Insubria, Varese, ItalyDepartment of Scientific and Research, Velleja Research, Milano, ItalyMicrobiota International Clinical Society, Torino, ItalyDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy0UOC Medicina Interna, Polo H1, ASL Rome, ItalyDepartment of Scientific and Research, Velleja Research, Milano, Italy1IRCCS-Azienda Ospedaliera di Bologna Sant' Orsola-Malpighi, Bologna, ItalyBackgroundHyperuricemia is associated with several metabolic and cardiovascular disorders, and traditional treatments, such as xanthine oxidase (XO) inhibitors, often have limitations, such as severe hypersensitivity reactions or ineffectiveness in achieving target serum urate levels in some patients. Quercetin, a naturally occurring flavonoid, has shown potential as a hypouricemic agent through XO inhibition.ObjectiveThis study aims to evaluate the potential hypouricemic effect of Quercetin Phytosome™ (QP) supplementation across three cohort studies involving healthy adults with various metabolic health profiles, exploring its potential as a safe, effective intervention for hyperuricemia.MethodsClinical data collected in various clinics in Italy between September 2021 and April 2024 under real-life clinical settings from three distinct cohort studies, were analyzed. Cohort 1 consisted of 164 healthy participants (87 QP-treated, 77 probiotic Streptococcus salivarius (S. salivarius) K12-treated) who were monitored for 90 days. Cohort 2 included 22 mildly hyperuricemic adults with metabolic disorders receiving QP, while Cohort 3 comprised 64 obese adults with hypercholesterolemia, further divided into moderately hyperuricemic QP-treated group (n = 20), a moderately hyperuricemic Berberine Phytosome™ and monacolins (BM)-treated group (n = 22), and a normouricemic BM-treated group (n = 22). QP was administered at 400 mg of quercetin daily in all cohorts. Primary endpoints were reductions in serum uric acid levels, while secondary outcomes included effects on lipid profile, glycemia, liver enzymes, and treatment tolerability.ResultsIn Cohort 1, QP significantly reduced uric acid levels by 15.2% in males and 13.8% in females, with no significant changes observed in the probiotic group. Cohort 2 showed a significant 13.1% reduction in uric acid (p < 0.01) and a concurrent 10.2% reduction in triglycerides (p < 0.05). In Cohort 3, QP led to a 13.7% decrease in uric acid and a 20.8% reduction in triglycerides (p < 0.01), with no significant uric acid changes in the BM-treated group. QP was well tolerated across all cohorts, with minimal, transient side effects.ConclusionQP supplementation demonstrates a significant hypouricemic effect. Additionally, triglyceride-lowering benefits were evident, particularly in metabolically compromised individuals (Cohorts 2 and 3), where these effects were statistically significant. With high tolerability, these findings highlight Quercetin Phytosome™'s potential as a safe adjunctive therapy for hyperuricemia management, meriting further investigation in larger, randomized trials to confirm its efficacy and safety.Clinical Trial Registrationclinicaltrials.gov, identifier NCT06652035.https://www.frontiersin.org/articles/10.3389/fnut.2025.1519459/fullhyperuricemiacardiovascular diseaseQuercetin Phytosome™Quevir®quercetinmetabolic health |
| spellingShingle | Francesco Di Pierro Francesco Di Pierro Francesco Di Pierro Fazle Rabbani Meherullah Tareen Roohi Nigar Amjad Khan Nicola Zerbinati Maria L. Tanda Massimiliano Cazzaniga Alexander Bertuccioli Alexander Bertuccioli Paolo Falasca Gabriele Damiani Nicola Villanova Potential pharmacological effect of Quercetin Phytosome™ in the management of hyperuricemia: results from real-life clinical studies Frontiers in Nutrition hyperuricemia cardiovascular disease Quercetin Phytosome™ Quevir® quercetin metabolic health |
| title | Potential pharmacological effect of Quercetin Phytosome™ in the management of hyperuricemia: results from real-life clinical studies |
| title_full | Potential pharmacological effect of Quercetin Phytosome™ in the management of hyperuricemia: results from real-life clinical studies |
| title_fullStr | Potential pharmacological effect of Quercetin Phytosome™ in the management of hyperuricemia: results from real-life clinical studies |
| title_full_unstemmed | Potential pharmacological effect of Quercetin Phytosome™ in the management of hyperuricemia: results from real-life clinical studies |
| title_short | Potential pharmacological effect of Quercetin Phytosome™ in the management of hyperuricemia: results from real-life clinical studies |
| title_sort | potential pharmacological effect of quercetin phytosome™ in the management of hyperuricemia results from real life clinical studies |
| topic | hyperuricemia cardiovascular disease Quercetin Phytosome™ Quevir® quercetin metabolic health |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1519459/full |
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