A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System
Fibromyalgia represents a chronic pain disorder characterized by musculoskeletal pain, fatigue, and cognitive impairments. The exact mechanisms underlying fibromyalgia remain undefined; as a result, diagnosis and treatment present considerable challenges. On the other hand, the endogenous opioid sys...
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MDPI AG
2025-01-01
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| Series: | Biomedicines |
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| author | Mario García-Domínguez |
| author_facet | Mario García-Domínguez |
| author_sort | Mario García-Domínguez |
| collection | DOAJ |
| description | Fibromyalgia represents a chronic pain disorder characterized by musculoskeletal pain, fatigue, and cognitive impairments. The exact mechanisms underlying fibromyalgia remain undefined; as a result, diagnosis and treatment present considerable challenges. On the other hand, the endogenous opioid system is believed to regulate pain intensity and emotional responses; hence, it might be expected to play a key role in the enhanced sensitivity experienced by fibromyalgia patients. One explanation for the emergence of disrupted pain modulation in individuals with fibromyalgia is a significant reduction in opioid receptor activity or an imbalance in the levels of endogenous opioid peptides. Further research is essential to clarify the complex details of the mechanisms underlying this abnormality. This complexity arises from the notion that an improved understanding could contribute to the development of innovative therapeutic strategies aimed at targeting the endogenous opioid system in the context of fibromyalgia. Although progress is being made, a complete understanding of these complexities remains a significant challenge. This paradigm has the potential to revolutionize the complex management of fibromyalgia, although its implementation may experience challenges. The effectiveness of this approach depends on multiple factors, but the implications could be profound. Despite the challenges involved in this transformation, the potential for improving patient care is considerable, as this condition has long been inadequately treated. |
| format | Article |
| id | doaj-art-8ddfb2b7e80949f6a850c6e8c02ca805 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-8ddfb2b7e80949f6a850c6e8c02ca8052025-01-24T13:24:14ZengMDPI AGBiomedicines2227-90592025-01-0113116510.3390/biomedicines13010165A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid SystemMario García-Domínguez0Program of Immunology and Immunotherapy, CIMA-Universidad de Navarra, 31008 Pamplona, SpainFibromyalgia represents a chronic pain disorder characterized by musculoskeletal pain, fatigue, and cognitive impairments. The exact mechanisms underlying fibromyalgia remain undefined; as a result, diagnosis and treatment present considerable challenges. On the other hand, the endogenous opioid system is believed to regulate pain intensity and emotional responses; hence, it might be expected to play a key role in the enhanced sensitivity experienced by fibromyalgia patients. One explanation for the emergence of disrupted pain modulation in individuals with fibromyalgia is a significant reduction in opioid receptor activity or an imbalance in the levels of endogenous opioid peptides. Further research is essential to clarify the complex details of the mechanisms underlying this abnormality. This complexity arises from the notion that an improved understanding could contribute to the development of innovative therapeutic strategies aimed at targeting the endogenous opioid system in the context of fibromyalgia. Although progress is being made, a complete understanding of these complexities remains a significant challenge. This paradigm has the potential to revolutionize the complex management of fibromyalgia, although its implementation may experience challenges. The effectiveness of this approach depends on multiple factors, but the implications could be profound. Despite the challenges involved in this transformation, the potential for improving patient care is considerable, as this condition has long been inadequately treated.https://www.mdpi.com/2227-9059/13/1/165central nervous system sensitizationchronic fatiguechronic painfibromyalgiamusculoskeletal painpain measurement |
| spellingShingle | Mario García-Domínguez A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System Biomedicines central nervous system sensitization chronic fatigue chronic pain fibromyalgia musculoskeletal pain pain measurement |
| title | A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System |
| title_full | A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System |
| title_fullStr | A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System |
| title_full_unstemmed | A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System |
| title_short | A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System |
| title_sort | comprehensive analysis of fibromyalgia and the role of the endogenous opioid system |
| topic | central nervous system sensitization chronic fatigue chronic pain fibromyalgia musculoskeletal pain pain measurement |
| url | https://www.mdpi.com/2227-9059/13/1/165 |
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