Evaluating atherogenic index of plasma as a predictor for metabolic syndrome: a cross-sectional analysis from Northern Taiwan
BackgroundThe rising global prevalence of metabolic syndrome (MetS), characterized by a constellation of cardiovascular risk factors, underscores the urgent need to identify reliable predictive biomarkers. We hypothesize that an elevated atherogenic index of plasma (AIP) predicts MetS risk through l...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1438254/full |
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| author | Liang-Sien Chen Liang-Sien Chen Liang-Sien Chen Liang-Sien Chen Yu-Rui Chen Yu-Rui Chen Yi-Hsiu Lin Yi-Hsiu Lin Hung-Keng Wu Hung-Keng Wu Yan Wen Lee Jau-Yuan Chen Jau-Yuan Chen |
| author_facet | Liang-Sien Chen Liang-Sien Chen Liang-Sien Chen Liang-Sien Chen Yu-Rui Chen Yu-Rui Chen Yi-Hsiu Lin Yi-Hsiu Lin Hung-Keng Wu Hung-Keng Wu Yan Wen Lee Jau-Yuan Chen Jau-Yuan Chen |
| author_sort | Liang-Sien Chen |
| collection | DOAJ |
| description | BackgroundThe rising global prevalence of metabolic syndrome (MetS), characterized by a constellation of cardiovascular risk factors, underscores the urgent need to identify reliable predictive biomarkers. We hypothesize that an elevated atherogenic index of plasma (AIP) predicts MetS risk through lipid imbalance, but population-specific variations in its predictive strength remain unexplored. Our study aimed to assess AIP), a ratio of triglycerides to high-density lipoprotein cholesterol, as a predictor of MetS.MethodBetween 2014 and 2018, our cross-sectional study collected and analyzed health examination data from 9,202 Northern Taiwan Medical Center employees without cardiovascular diseases, diabetes, and end-stage renal disease (ESRD). Our study classified AIP levels equally into three tertiles and evaluated their impact on MetS through a logistic regression model.ResultsAfter adjusting for age, gender, BMI, SBP, FPG, and LDL in our models, the ORs for MetS in the second and third tertiles of the AIP were 3.81 (95% CI: 2.33 to 6.21; OR: 37.14, 95%: 23.22 to 59.39). In addition, women have a higher MetS risk associated with elevated AIP than men across all models.ConclusionOur research identified the AIP as a significant predictive marker for the prevalence of MetS, suggesting its potential utility in clinical risk assessment and indicating the need for further research to explore its application in preventive strategies and therapeutic interventions. |
| format | Article |
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| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-8ddad92c0f664e73b633ad46eee021282025-01-13T05:10:15ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.14382541438254Evaluating atherogenic index of plasma as a predictor for metabolic syndrome: a cross-sectional analysis from Northern TaiwanLiang-Sien Chen0Liang-Sien Chen1Liang-Sien Chen2Liang-Sien Chen3Yu-Rui Chen4Yu-Rui Chen5Yi-Hsiu Lin6Yi-Hsiu Lin7Hung-Keng Wu8Hung-Keng Wu9Yan Wen Lee10Jau-Yuan Chen11Jau-Yuan Chen12Department of Family Medicine, Chang-Gung Memorial Hospital, Taoyuan, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Medication Education, Chang-Gung Memorial Hospital, Taoyuan, TaiwanSchool of Public Health, Taipei Medical University, Taipei, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Medication Education, Chang-Gung Memorial Hospital, Taoyuan, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Medication Education, Chang-Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Family Medicine, Chang-Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Medication Education, Chang-Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Family Medicine, Chang-Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Family Medicine, Chang-Gung Memorial Hospital, Taoyuan, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanBackgroundThe rising global prevalence of metabolic syndrome (MetS), characterized by a constellation of cardiovascular risk factors, underscores the urgent need to identify reliable predictive biomarkers. We hypothesize that an elevated atherogenic index of plasma (AIP) predicts MetS risk through lipid imbalance, but population-specific variations in its predictive strength remain unexplored. Our study aimed to assess AIP), a ratio of triglycerides to high-density lipoprotein cholesterol, as a predictor of MetS.MethodBetween 2014 and 2018, our cross-sectional study collected and analyzed health examination data from 9,202 Northern Taiwan Medical Center employees without cardiovascular diseases, diabetes, and end-stage renal disease (ESRD). Our study classified AIP levels equally into three tertiles and evaluated their impact on MetS through a logistic regression model.ResultsAfter adjusting for age, gender, BMI, SBP, FPG, and LDL in our models, the ORs for MetS in the second and third tertiles of the AIP were 3.81 (95% CI: 2.33 to 6.21; OR: 37.14, 95%: 23.22 to 59.39). In addition, women have a higher MetS risk associated with elevated AIP than men across all models.ConclusionOur research identified the AIP as a significant predictive marker for the prevalence of MetS, suggesting its potential utility in clinical risk assessment and indicating the need for further research to explore its application in preventive strategies and therapeutic interventions.https://www.frontiersin.org/articles/10.3389/fendo.2024.1438254/fullatherogenic index of plasmatriglycerideshigh-density lipoprotein cholesterolmetabolic syndromewomen |
| spellingShingle | Liang-Sien Chen Liang-Sien Chen Liang-Sien Chen Liang-Sien Chen Yu-Rui Chen Yu-Rui Chen Yi-Hsiu Lin Yi-Hsiu Lin Hung-Keng Wu Hung-Keng Wu Yan Wen Lee Jau-Yuan Chen Jau-Yuan Chen Evaluating atherogenic index of plasma as a predictor for metabolic syndrome: a cross-sectional analysis from Northern Taiwan Frontiers in Endocrinology atherogenic index of plasma triglycerides high-density lipoprotein cholesterol metabolic syndrome women |
| title | Evaluating atherogenic index of plasma as a predictor for metabolic syndrome: a cross-sectional analysis from Northern Taiwan |
| title_full | Evaluating atherogenic index of plasma as a predictor for metabolic syndrome: a cross-sectional analysis from Northern Taiwan |
| title_fullStr | Evaluating atherogenic index of plasma as a predictor for metabolic syndrome: a cross-sectional analysis from Northern Taiwan |
| title_full_unstemmed | Evaluating atherogenic index of plasma as a predictor for metabolic syndrome: a cross-sectional analysis from Northern Taiwan |
| title_short | Evaluating atherogenic index of plasma as a predictor for metabolic syndrome: a cross-sectional analysis from Northern Taiwan |
| title_sort | evaluating atherogenic index of plasma as a predictor for metabolic syndrome a cross sectional analysis from northern taiwan |
| topic | atherogenic index of plasma triglycerides high-density lipoprotein cholesterol metabolic syndrome women |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1438254/full |
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