Comparative pathogenicity and environmental transmission of recent highly pathogenic avian influenza H5 viruses
Strategies to control spread of highly pathogenic avian influenza (HPAI) viruses by wild birds appear limited, hence timely characterization of novel viruses is important to mitigate the risk for the poultry sector and human health. In this study we characterize three recent H5-clade 2.3.4.4 viruses...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-01-01
|
| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2020.1868274 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850032229274615808 |
|---|---|
| author | Nancy Beerens Evelien A. Germeraad Sandra Venema Eline Verheij Sylvia B.E. Pritz-Verschuren Jose L. Gonzales |
| author_facet | Nancy Beerens Evelien A. Germeraad Sandra Venema Eline Verheij Sylvia B.E. Pritz-Verschuren Jose L. Gonzales |
| author_sort | Nancy Beerens |
| collection | DOAJ |
| description | Strategies to control spread of highly pathogenic avian influenza (HPAI) viruses by wild birds appear limited, hence timely characterization of novel viruses is important to mitigate the risk for the poultry sector and human health. In this study we characterize three recent H5-clade 2.3.4.4 viruses, the H5N8-2014 group A virus and the H5N8-2016 and H5N6-2017 group B viruses. The pathogenicity of the three viruses for chickens, Pekin ducks and Eurasian wigeons was compared. The three viruses were highly pathogenic for chickens, but the two H5N8 viruses caused no to mild clinical symptoms in both duck species. The highest pathogenicity for duck species was observed for the most recent H5N6-2017 virus. For both duck species, virus shedding from the cloaca was higher after infection with group B viruses compared to the H5N8-2014 group A virus. Higher cloacal virus shedding of wild ducks may increase transmission between wild birds and poultry. Environmental transmission of H5N8-2016 virus to chickens was studied, which showed that chickens are efficiently infected by (fecal) contaminated water. These results suggest that pathogenicity of HPAI H5 viruses and virus shedding for ducks is evolving, which may have implications for the risk of introduction of these viruses into the poultry sector. |
| format | Article |
| id | doaj-art-8dda3999b7cd46cdbccd0401f998f407 |
| institution | DOAJ |
| issn | 2222-1751 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-8dda3999b7cd46cdbccd0401f998f4072025-08-20T02:58:43ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512021-01-011019710810.1080/22221751.2020.1868274Comparative pathogenicity and environmental transmission of recent highly pathogenic avian influenza H5 virusesNancy Beerens0Evelien A. Germeraad1Sandra Venema2Eline Verheij3Sylvia B.E. Pritz-Verschuren4Jose L. Gonzales5Wageningen University and Research – Wageningen Bioveterinary Research, Lelystad, The NetherlandsWageningen University and Research – Wageningen Bioveterinary Research, Lelystad, The NetherlandsWageningen University and Research – Wageningen Bioveterinary Research, Lelystad, The NetherlandsWageningen University and Research – Wageningen Bioveterinary Research, Lelystad, The NetherlandsWageningen University and Research – Wageningen Bioveterinary Research, Lelystad, The NetherlandsWageningen University and Research – Wageningen Bioveterinary Research, Lelystad, The NetherlandsStrategies to control spread of highly pathogenic avian influenza (HPAI) viruses by wild birds appear limited, hence timely characterization of novel viruses is important to mitigate the risk for the poultry sector and human health. In this study we characterize three recent H5-clade 2.3.4.4 viruses, the H5N8-2014 group A virus and the H5N8-2016 and H5N6-2017 group B viruses. The pathogenicity of the three viruses for chickens, Pekin ducks and Eurasian wigeons was compared. The three viruses were highly pathogenic for chickens, but the two H5N8 viruses caused no to mild clinical symptoms in both duck species. The highest pathogenicity for duck species was observed for the most recent H5N6-2017 virus. For both duck species, virus shedding from the cloaca was higher after infection with group B viruses compared to the H5N8-2014 group A virus. Higher cloacal virus shedding of wild ducks may increase transmission between wild birds and poultry. Environmental transmission of H5N8-2016 virus to chickens was studied, which showed that chickens are efficiently infected by (fecal) contaminated water. These results suggest that pathogenicity of HPAI H5 viruses and virus shedding for ducks is evolving, which may have implications for the risk of introduction of these viruses into the poultry sector.https://www.tandfonline.com/doi/10.1080/22221751.2020.1868274Highly pathogenic avian influenzaH5N8H5N6pathogenicityvirus sheddingducks |
| spellingShingle | Nancy Beerens Evelien A. Germeraad Sandra Venema Eline Verheij Sylvia B.E. Pritz-Verschuren Jose L. Gonzales Comparative pathogenicity and environmental transmission of recent highly pathogenic avian influenza H5 viruses Emerging Microbes and Infections Highly pathogenic avian influenza H5N8 H5N6 pathogenicity virus shedding ducks |
| title | Comparative pathogenicity and environmental transmission of recent highly pathogenic avian influenza H5 viruses |
| title_full | Comparative pathogenicity and environmental transmission of recent highly pathogenic avian influenza H5 viruses |
| title_fullStr | Comparative pathogenicity and environmental transmission of recent highly pathogenic avian influenza H5 viruses |
| title_full_unstemmed | Comparative pathogenicity and environmental transmission of recent highly pathogenic avian influenza H5 viruses |
| title_short | Comparative pathogenicity and environmental transmission of recent highly pathogenic avian influenza H5 viruses |
| title_sort | comparative pathogenicity and environmental transmission of recent highly pathogenic avian influenza h5 viruses |
| topic | Highly pathogenic avian influenza H5N8 H5N6 pathogenicity virus shedding ducks |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2020.1868274 |
| work_keys_str_mv | AT nancybeerens comparativepathogenicityandenvironmentaltransmissionofrecenthighlypathogenicavianinfluenzah5viruses AT evelienagermeraad comparativepathogenicityandenvironmentaltransmissionofrecenthighlypathogenicavianinfluenzah5viruses AT sandravenema comparativepathogenicityandenvironmentaltransmissionofrecenthighlypathogenicavianinfluenzah5viruses AT elineverheij comparativepathogenicityandenvironmentaltransmissionofrecenthighlypathogenicavianinfluenzah5viruses AT sylviabepritzverschuren comparativepathogenicityandenvironmentaltransmissionofrecenthighlypathogenicavianinfluenzah5viruses AT joselgonzales comparativepathogenicityandenvironmentaltransmissionofrecenthighlypathogenicavianinfluenzah5viruses |