Quantitative levels of interferon gamma as a biomarker in the aqueous and serum samples of infectious and noninfectious uveitis patients

Quantitative levels of interferon gamma as a biomarker in the aqueous and serum samples of infectious and noninfectious uveitis patients

Abstract Background To study the utility of interferon gamma (IFN-γ) as a differentiating biomarker by assessing the aqueous humour and serum of patients with infectious and noninfectious uveitis. Methods A total of 40 patients with acute uveitis were divided into 2 groups (18 patients with infectio...

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Main Authors: Sahar Saad Eldeen Mohamed Shaban, Hend Mohammed Safwat, Abeer Mohammed Abdelmohymen, Donia Ahmed Hassan, Mona Nabeh Mansour, Hanan Said Mohammed, Nora Seliem, Shahinaz El Attar, Doaa Refaat Amin, Seham Kamal Ahmed Khirala, Aya Ahmed Ghamry, Mona Gamal El Din Al Anany, Shaymaa Fathy Mohammed
Format: Article
Language:English
Published: SpringerOpen 2025-02-01
Series:Journal of Ophthalmic Inflammation and Infection
Subjects:
Uveitis
Biomarker
Infectious
Noninfectious
Interferon gamma
Online Access:https://doi.org/10.1186/s12348-025-00461-1
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Summary:Abstract Background To study the utility of interferon gamma (IFN-γ) as a differentiating biomarker by assessing the aqueous humour and serum of patients with infectious and noninfectious uveitis. Methods A total of 40 patients with acute uveitis were divided into 2 groups (18 patients with infectious uveitis and 22 patients with noninfectious uveitis). All the subjects underwent a full ophthalmological examination. Aqueous humour (AqH) and serum samples were collected from uveitis patients. The quantitative levels of IFN-γ in aqueous medium and serum were measured by means of an enzyme-linked immunosorbent assay (ELISA). Results The quantitative level of IFN-γ in the aqueous humour was significantly greater (87.5 ± 81) (pg/ml) in infectious uveitis patients than in noninfectious uveitis patients (37.3 ± 9.9) (pg/ml) (p value = 0.006). However, the serum IFN-γ level (pg/ml) did not significantly differ between these groups (p value = 0.279). Thus, the IFN-γ level in the aqueous humour can be used to discriminate between infectious and noninfectious uveitis with 33.3% sensitivity and 100% specificity. Conclusion Aqueous IFN-γ can be used as a biomarker for differentiating between infectious and noninfectious uveitis.
ISSN:1869-5760

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