The Impact of In‐Hospital Disease Modifying Treatments on Mental and Physical Burden in Caregiver of Patients With MS
ABSTRACT Objective People with multiple sclerosis (pwMS) may require a high level of daily assistance both for indoor and outdoor activities. Usually, relatives or friends provide daily support to MS patients who have lost personal autonomy. Several factors such as disability level and disease durat...
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Wiley
2025-05-01
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| Series: | Annals of Clinical and Translational Neurology |
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| Online Access: | https://doi.org/10.1002/acn3.70026 |
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| author | Giuseppe Schirò Salvatore Iacono Michele Andolina Gabriele Sorbello Andrea Calì Erika Gentile Marco D'Amelio Paolo Aridon Giuseppe Salemi Paolo Ragonese |
| author_facet | Giuseppe Schirò Salvatore Iacono Michele Andolina Gabriele Sorbello Andrea Calì Erika Gentile Marco D'Amelio Paolo Aridon Giuseppe Salemi Paolo Ragonese |
| author_sort | Giuseppe Schirò |
| collection | DOAJ |
| description | ABSTRACT Objective People with multiple sclerosis (pwMS) may require a high level of daily assistance both for indoor and outdoor activities. Usually, relatives or friends provide daily support to MS patients who have lost personal autonomy. Several factors such as disability level and disease duration may affect the burden of care in caregivers of pwMS; however, the relationship between disease‐modifying therapies (DMTs) and caregiver burden has never been explored so far. The aim of this study is to explore the impact of hospital‐based therapies on anxiety, depression, and burden of care in caregivers of pwMS. Methods Hospital Anxiety and the Depression Scale (HADS) and Caregiver Burden Inventory (CBI) questionnaires were administered to caregivers of pwMS who performed planned visits in the outpatient setting. Multivariable regression models were built to evaluate the association between hospital‐based therapies and depression (HADS‐D > 7), anxiety (HADS‐A > 7) and need to rest (CBI > 24). Results Caregivers of pwMS receiving in‐hospital therapies achieved higher scores in HADS and CBI questionnaires, resulting in a higher proportion of anxiety, depression, and need to rest among these. The multivariable models also showed that hospital‐based therapies were positively associated with caregivers' depression (aOR = 2.38 [1.04–5.5; p = 0.04]), anxiety (aOR = 2.36 [1.03–5.4; p = 0.043]) and need to rest (aOR = 2.06 [0.8–5.29]; p = 0.13). Interpretation Hospital‐based therapies in pwMS negatively affect the burden of care and mental health of their own caregivers. The availability of home‐based highly effective DMTs may contribute to reducing the outdoor caregiver burden without renouncing highly effective treatments. |
| format | Article |
| id | doaj-art-8dd2c51ad57a4b889a64e88b662172ef |
| institution | OA Journals |
| issn | 2328-9503 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj-art-8dd2c51ad57a4b889a64e88b662172ef2025-08-20T01:52:39ZengWileyAnnals of Clinical and Translational Neurology2328-95032025-05-0112595896510.1002/acn3.70026The Impact of In‐Hospital Disease Modifying Treatments on Mental and Physical Burden in Caregiver of Patients With MSGiuseppe Schirò0Salvatore Iacono1Michele Andolina2Gabriele Sorbello3Andrea Calì4Erika Gentile5Marco D'Amelio6Paolo Aridon7Giuseppe Salemi8Paolo Ragonese9Department of Biomedicine, Neurosciences and Advanced Diagnostics (BiND) University of Palermo Palermo ItalyDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BiND) University of Palermo Palermo ItalyDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BiND) University of Palermo Palermo ItalyDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BiND) University of Palermo Palermo ItalyDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BiND) University of Palermo Palermo ItalyDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BiND) University of Palermo Palermo ItalyDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BiND) University of Palermo Palermo ItalyDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BiND) University of Palermo Palermo ItalyDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BiND) University of Palermo Palermo ItalyDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BiND) University of Palermo Palermo ItalyABSTRACT Objective People with multiple sclerosis (pwMS) may require a high level of daily assistance both for indoor and outdoor activities. Usually, relatives or friends provide daily support to MS patients who have lost personal autonomy. Several factors such as disability level and disease duration may affect the burden of care in caregivers of pwMS; however, the relationship between disease‐modifying therapies (DMTs) and caregiver burden has never been explored so far. The aim of this study is to explore the impact of hospital‐based therapies on anxiety, depression, and burden of care in caregivers of pwMS. Methods Hospital Anxiety and the Depression Scale (HADS) and Caregiver Burden Inventory (CBI) questionnaires were administered to caregivers of pwMS who performed planned visits in the outpatient setting. Multivariable regression models were built to evaluate the association between hospital‐based therapies and depression (HADS‐D > 7), anxiety (HADS‐A > 7) and need to rest (CBI > 24). Results Caregivers of pwMS receiving in‐hospital therapies achieved higher scores in HADS and CBI questionnaires, resulting in a higher proportion of anxiety, depression, and need to rest among these. The multivariable models also showed that hospital‐based therapies were positively associated with caregivers' depression (aOR = 2.38 [1.04–5.5; p = 0.04]), anxiety (aOR = 2.36 [1.03–5.4; p = 0.043]) and need to rest (aOR = 2.06 [0.8–5.29]; p = 0.13). Interpretation Hospital‐based therapies in pwMS negatively affect the burden of care and mental health of their own caregivers. The availability of home‐based highly effective DMTs may contribute to reducing the outdoor caregiver burden without renouncing highly effective treatments.https://doi.org/10.1002/acn3.70026caregiver burden of carehome‐based disease modifying treatmentsmental healthmultiple sclerosisunmet need |
| spellingShingle | Giuseppe Schirò Salvatore Iacono Michele Andolina Gabriele Sorbello Andrea Calì Erika Gentile Marco D'Amelio Paolo Aridon Giuseppe Salemi Paolo Ragonese The Impact of In‐Hospital Disease Modifying Treatments on Mental and Physical Burden in Caregiver of Patients With MS Annals of Clinical and Translational Neurology caregiver burden of care home‐based disease modifying treatments mental health multiple sclerosis unmet need |
| title | The Impact of In‐Hospital Disease Modifying Treatments on Mental and Physical Burden in Caregiver of Patients With MS |
| title_full | The Impact of In‐Hospital Disease Modifying Treatments on Mental and Physical Burden in Caregiver of Patients With MS |
| title_fullStr | The Impact of In‐Hospital Disease Modifying Treatments on Mental and Physical Burden in Caregiver of Patients With MS |
| title_full_unstemmed | The Impact of In‐Hospital Disease Modifying Treatments on Mental and Physical Burden in Caregiver of Patients With MS |
| title_short | The Impact of In‐Hospital Disease Modifying Treatments on Mental and Physical Burden in Caregiver of Patients With MS |
| title_sort | impact of in hospital disease modifying treatments on mental and physical burden in caregiver of patients with ms |
| topic | caregiver burden of care home‐based disease modifying treatments mental health multiple sclerosis unmet need |
| url | https://doi.org/10.1002/acn3.70026 |
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