Serological evaluation of Crimean-Congo Hemorrhagic fever in humans with High-Risk professional exposure and in residual sera collected in 2022-2023 across Corsica (France)
Background: The Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen known to cause severe viral hemorrhagic fever. Aim: We aimed to evaluate the potential circulation of CCHFV in Corsica through a serosurvey, including anonymized residual sera (RS) and high-risk individuals expose...
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Elsevier
2025-06-01
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| Series: | One Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352771425000564 |
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| author | Paloma Kiwan Morena Gasparine Dorine Decarreaux Lisandru Capai Shirley Masse Miša Korva Tatjana Avšič-Županc Jean Canarelli Marie-Helene Simeoni Xavier de Lamballerie Remi Charrel Alessandra Falchi |
| author_facet | Paloma Kiwan Morena Gasparine Dorine Decarreaux Lisandru Capai Shirley Masse Miša Korva Tatjana Avšič-Županc Jean Canarelli Marie-Helene Simeoni Xavier de Lamballerie Remi Charrel Alessandra Falchi |
| author_sort | Paloma Kiwan |
| collection | DOAJ |
| description | Background: The Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen known to cause severe viral hemorrhagic fever. Aim: We aimed to evaluate the potential circulation of CCHFV in Corsica through a serosurvey, including anonymized residual sera (RS) and high-risk individuals exposed to animals and/or tick bites due to occupational activities. Methods: This cross-sectional study involved two groups: anonymized RS from medical biology laboratories and sera from high-risk individuals (slaughterhouse workers, veterinary professionals, animal farmers, and rangers) collected across Corsica during 2022–2023. Antibodies targeting the CCHFV viral nucleoprotein were detected using a double-antigen ELISA. ELISA-positive samples underwent neutralizing antibody testing. Sociodemographic and epidemiological data were collected using a structured questionnaire in the high-risk group. Results: Total anti-CCHFV seropositivity was of 0.08 % (n = 2) [95 % Confidence Interval (CI): 0.06–0.09] in RS and of 0.50 % (n = 1) [95 % CI: 0.43–0.56] in high-risk groups (p < 0.01). Lifetime tick-bites was reported by 65.9 % (n = 118) of respondents, with higher rates among farmers (Odds Ratio (OR) = 3.4; 95 % CI 1.4–8.5) and participants with >10 years of occupational exposure (OR = 3.8; 95 % CI 1.7–8.5). Conclusions: This study provides initial evidence of human exposure to CCHFV in Corsica, with rates consistent with those observed in other Western European regions. Our results indicate a risk of CCHF among the Corsican population, particularly among farmers and slaughterhouse workers. Continuous surveillance and public education are essential to mitigate this risk, especially among these targeted groups and healthcare professionals, ensuring prompt diagnosis and prevention of potential outbreaks. |
| format | Article |
| id | doaj-art-8dd0d43b445c48e08d5575bd3ecc0c8a |
| institution | OA Journals |
| issn | 2352-7714 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
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| series | One Health |
| spelling | doaj-art-8dd0d43b445c48e08d5575bd3ecc0c8a2025-08-20T02:36:02ZengElsevierOne Health2352-77142025-06-012010102010.1016/j.onehlt.2025.101020Serological evaluation of Crimean-Congo Hemorrhagic fever in humans with High-Risk professional exposure and in residual sera collected in 2022-2023 across Corsica (France)Paloma Kiwan0Morena Gasparine1Dorine Decarreaux2Lisandru Capai3Shirley Masse4Miša Korva5Tatjana Avšič-Županc6Jean Canarelli7Marie-Helene Simeoni8Xavier de Lamballerie9Remi Charrel10Alessandra Falchi11Unité des Virus Émergents (Aix Marseille Université, Università di Corsica, IRD 190, INSERM 1207, IRBA), Marseille, France; Corresponding author.Unité des Virus Émergents (Aix Marseille Université, Università di Corsica, IRD 190, INSERM 1207, IRBA), Marseille, FranceUnité des Virus Émergents (Aix Marseille Université, Università di Corsica, IRD 190, INSERM 1207, IRBA), Marseille, FranceUnité des Virus Émergents (Aix Marseille Université, Università di Corsica, IRD 190, INSERM 1207, IRBA), Marseille, FranceUnité des Virus Émergents (Aix Marseille Université, Università di Corsica, IRD 190, INSERM 1207, IRBA), Marseille, FranceInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaLaboratoire de Biologie Médicale CCF, Ajaccio, FranceLaboratoire de Biologie Médicale 2A2B, Corte, FranceUnité des Virus Émergents (Aix Marseille Université, Università di Corsica, IRD 190, INSERM 1207, IRBA), Marseille, France; Centre National de Référence des Arbovirus, Marseille, FranceUnité des Virus Émergents (Aix Marseille Université, Università di Corsica, IRD 190, INSERM 1207, IRBA), Marseille, FranceUnité des Virus Émergents (Aix Marseille Université, Università di Corsica, IRD 190, INSERM 1207, IRBA), Marseille, FranceBackground: The Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen known to cause severe viral hemorrhagic fever. Aim: We aimed to evaluate the potential circulation of CCHFV in Corsica through a serosurvey, including anonymized residual sera (RS) and high-risk individuals exposed to animals and/or tick bites due to occupational activities. Methods: This cross-sectional study involved two groups: anonymized RS from medical biology laboratories and sera from high-risk individuals (slaughterhouse workers, veterinary professionals, animal farmers, and rangers) collected across Corsica during 2022–2023. Antibodies targeting the CCHFV viral nucleoprotein were detected using a double-antigen ELISA. ELISA-positive samples underwent neutralizing antibody testing. Sociodemographic and epidemiological data were collected using a structured questionnaire in the high-risk group. Results: Total anti-CCHFV seropositivity was of 0.08 % (n = 2) [95 % Confidence Interval (CI): 0.06–0.09] in RS and of 0.50 % (n = 1) [95 % CI: 0.43–0.56] in high-risk groups (p < 0.01). Lifetime tick-bites was reported by 65.9 % (n = 118) of respondents, with higher rates among farmers (Odds Ratio (OR) = 3.4; 95 % CI 1.4–8.5) and participants with >10 years of occupational exposure (OR = 3.8; 95 % CI 1.7–8.5). Conclusions: This study provides initial evidence of human exposure to CCHFV in Corsica, with rates consistent with those observed in other Western European regions. Our results indicate a risk of CCHF among the Corsican population, particularly among farmers and slaughterhouse workers. Continuous surveillance and public education are essential to mitigate this risk, especially among these targeted groups and healthcare professionals, ensuring prompt diagnosis and prevention of potential outbreaks.http://www.sciencedirect.com/science/article/pii/S2352771425000564Crimean-Congo Hemorrhagic Fever Virus (CCHFV)Tick-borne virusSeroprevalenceTick biteHigh-riskHuman populations |
| spellingShingle | Paloma Kiwan Morena Gasparine Dorine Decarreaux Lisandru Capai Shirley Masse Miša Korva Tatjana Avšič-Županc Jean Canarelli Marie-Helene Simeoni Xavier de Lamballerie Remi Charrel Alessandra Falchi Serological evaluation of Crimean-Congo Hemorrhagic fever in humans with High-Risk professional exposure and in residual sera collected in 2022-2023 across Corsica (France) One Health Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Tick-borne virus Seroprevalence Tick bite High-risk Human populations |
| title | Serological evaluation of Crimean-Congo Hemorrhagic fever in humans with High-Risk professional exposure and in residual sera collected in 2022-2023 across Corsica (France) |
| title_full | Serological evaluation of Crimean-Congo Hemorrhagic fever in humans with High-Risk professional exposure and in residual sera collected in 2022-2023 across Corsica (France) |
| title_fullStr | Serological evaluation of Crimean-Congo Hemorrhagic fever in humans with High-Risk professional exposure and in residual sera collected in 2022-2023 across Corsica (France) |
| title_full_unstemmed | Serological evaluation of Crimean-Congo Hemorrhagic fever in humans with High-Risk professional exposure and in residual sera collected in 2022-2023 across Corsica (France) |
| title_short | Serological evaluation of Crimean-Congo Hemorrhagic fever in humans with High-Risk professional exposure and in residual sera collected in 2022-2023 across Corsica (France) |
| title_sort | serological evaluation of crimean congo hemorrhagic fever in humans with high risk professional exposure and in residual sera collected in 2022 2023 across corsica france |
| topic | Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Tick-borne virus Seroprevalence Tick bite High-risk Human populations |
| url | http://www.sciencedirect.com/science/article/pii/S2352771425000564 |
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