Knockout of the histone methyltransferase NSD1 leads to a decrease in cell proliferation and an increase in sensitivity to cisplatin in laryngeal squamous cell carcinoma

Knockout of the histone methyltransferase NSD1 leads to a decrease in cell proliferation and an increase in sensitivity to cisplatin in laryngeal squamous cell carcinoma

Introduction. The histone methylation regulates gene expression and plays a role in genomic stability participating in DNA repair. Dimethylation of histone 3 lysine 36 (H3K36me2) is an important histone modification which is responsible for gene expression activation. H3K36me2 is a product of methyl...

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Bibliographic Details
Main Authors: I. A. Topchu, M. V. Tikhomirova, E. R. Bulatov, Z. I. Abramova, Y. A. Boumber
Format: Article
Language:Russian
Published: Russian Academy of Sciences, Tomsk National Research Medical Center 2023-05-01
Series:Сибирский онкологический журнал
Subjects:
histone methylation
nsd1
head and neck squamous cell carcinoma
crispr/cas9
Online Access:https://www.siboncoj.ru/jour/article/view/2531
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