An interpretable artificial intelligence framework for designing synthetic lethality-based anti-cancer combination therapies

An interpretable artificial intelligence framework for designing synthetic lethality-based anti-cancer combination therapies

Introduction: Synthetic lethality (SL) provides an opportunity to leverage different genetic interactions when designing synergistic combination therapies. To further explore SL-based combination therapies for cancer treatment, it is important to identify and mechanistically characterize more SL int...

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Bibliographic Details
Main Authors: Jing Wang, Yuqi Wen, Yixin Zhang, Zhongming Wang, Yuyang Jiang, Chong Dai, Lianlian Wu, Dongjin Leng, Song He, Xiaochen Bo
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Journal of Advanced Research
Subjects:
Synthetic lethality
Combination therapy
Knowledge-driven
Data-driven
Artificial intelligence
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123223003740
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