MOLECULAR MECHANISMS OF DEACTIVATION OF DENDRITIC CELLS IN PATIENTS WITH PULMONARY TUBERCULOSIS
We have investigated dendritic cells (DC), obtained by transformation from peripheral blood monocytes. We show the possible mechanisms of infringement of dendritic cells (DC) functional activity in patients with pulmonary tuberculosis (TB). Found that in patients with TB the number of DC, expressing...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2013-02-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/60 |
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| author | Z. K. Khaitova |
| author_facet | Z. K. Khaitova |
| author_sort | Z. K. Khaitova |
| collection | DOAJ |
| description | We have investigated dendritic cells (DC), obtained by transformation from peripheral blood monocytes. We show the possible mechanisms of infringement of dendritic cells (DC) functional activity in patients with pulmonary tuberculosis (TB). Found that in patients with TB the number of DC, expressing TLR2, costimulation molecules CD86, is reduced, secretion of cytokine IL-12 changes. It is possible the mecha-nisms of deactivation DC mediated from effects of M. tuberculosis |
| format | Article |
| id | doaj-art-8dc496d09c7648af92bbb1ee79ee1b3a |
| institution | DOAJ |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2013-02-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-8dc496d09c7648af92bbb1ee79ee1b3a2025-08-20T03:02:25ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842013-02-0112113914210.20538/1682-0363-2013-1-139-14258MOLECULAR MECHANISMS OF DEACTIVATION OF DENDRITIC CELLS IN PATIENTS WITH PULMONARY TUBERCULOSISZ. K. Khaitova0Siberian State Medical University, TomskWe have investigated dendritic cells (DC), obtained by transformation from peripheral blood monocytes. We show the possible mechanisms of infringement of dendritic cells (DC) functional activity in patients with pulmonary tuberculosis (TB). Found that in patients with TB the number of DC, expressing TLR2, costimulation molecules CD86, is reduced, secretion of cytokine IL-12 changes. It is possible the mecha-nisms of deactivation DC mediated from effects of M. tuberculosishttps://bulletin.ssmu.ru/jour/article/view/60dendritic cellstuberculosiscytokinescostimulatory molecules |
| spellingShingle | Z. K. Khaitova MOLECULAR MECHANISMS OF DEACTIVATION OF DENDRITIC CELLS IN PATIENTS WITH PULMONARY TUBERCULOSIS Бюллетень сибирской медицины dendritic cells tuberculosis cytokines costimulatory molecules |
| title | MOLECULAR MECHANISMS OF DEACTIVATION OF DENDRITIC CELLS IN PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_full | MOLECULAR MECHANISMS OF DEACTIVATION OF DENDRITIC CELLS IN PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_fullStr | MOLECULAR MECHANISMS OF DEACTIVATION OF DENDRITIC CELLS IN PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_full_unstemmed | MOLECULAR MECHANISMS OF DEACTIVATION OF DENDRITIC CELLS IN PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_short | MOLECULAR MECHANISMS OF DEACTIVATION OF DENDRITIC CELLS IN PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_sort | molecular mechanisms of deactivation of dendritic cells in patients with pulmonary tuberculosis |
| topic | dendritic cells tuberculosis cytokines costimulatory molecules |
| url | https://bulletin.ssmu.ru/jour/article/view/60 |
| work_keys_str_mv | AT zkkhaitova molecularmechanismsofdeactivationofdendriticcellsinpatientswithpulmonarytuberculosis |