Advances in the study of key cells and signaling pathways in renal fibrosis and the interventional role of Chinese medicines
Renal fibrosis (RF) is a pathological process characterized by the excessive accumulation of extracellular matrix (ECM), which triggers a repair cascade in response to stimuli and pathogenic factors, leading to the activation of molecular signaling pathways involved in fibrosis. This article discuss...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1403227/full |
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| author | Lijuan Liang Lijuan Liang Youjun Mi Shihan Zhou Aojian Yang Chaoyu Wei Enlai Dai |
| author_facet | Lijuan Liang Lijuan Liang Youjun Mi Shihan Zhou Aojian Yang Chaoyu Wei Enlai Dai |
| author_sort | Lijuan Liang |
| collection | DOAJ |
| description | Renal fibrosis (RF) is a pathological process characterized by the excessive accumulation of extracellular matrix (ECM), which triggers a repair cascade in response to stimuli and pathogenic factors, leading to the activation of molecular signaling pathways involved in fibrosis. This article discusses the key cells, molecules, and signaling pathways implicated in the pathogenesis of RF, with a particular focus on tubular epithelial cells (TECs), cellular senescence, ferroptosis, autophagy, epithelial-mesenchymal transition (EMT), and transforming growth factor-β(TGF-β)/Smad signaling. These factors drive the core and regulatory pathways that significantly influence RF. A comprehensive understanding of their roles is essential. Through a literature review, we explore recent advancements in traditional Chinese medicine (TCM) aimed at reducing RF and inhibiting chronic kidney disease (CKD). We summarize, analyze, and elaborate on the important role of Chinese herbs in RF, aiming to provide new directions for their application in prevention and treatment, as well as scientific guidance for clinical practices. |
| format | Article |
| id | doaj-art-8dc2ef342a92478192bef9e868e7c933 |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-8dc2ef342a92478192bef9e868e7c9332025-08-20T02:50:53ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-12-011510.3389/fphar.2024.14032271403227Advances in the study of key cells and signaling pathways in renal fibrosis and the interventional role of Chinese medicinesLijuan Liang0Lijuan Liang1Youjun Mi2Shihan Zhou3Aojian Yang4Chaoyu Wei5Enlai Dai6Gansu University of Chinese Medicine, Lanzhou, ChinaKey Laboratory of Dunhuang Medicine and Translation, Ministry of Education, Lanzhou, ChinaInstitute of pathophysiology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, ChinaGansu University of Chinese Medicine, Lanzhou, ChinaGansu University of Chinese Medicine, Lanzhou, ChinaGansu University of Chinese Medicine, Lanzhou, ChinaGansu University of Chinese Medicine, Lanzhou, ChinaRenal fibrosis (RF) is a pathological process characterized by the excessive accumulation of extracellular matrix (ECM), which triggers a repair cascade in response to stimuli and pathogenic factors, leading to the activation of molecular signaling pathways involved in fibrosis. This article discusses the key cells, molecules, and signaling pathways implicated in the pathogenesis of RF, with a particular focus on tubular epithelial cells (TECs), cellular senescence, ferroptosis, autophagy, epithelial-mesenchymal transition (EMT), and transforming growth factor-β(TGF-β)/Smad signaling. These factors drive the core and regulatory pathways that significantly influence RF. A comprehensive understanding of their roles is essential. Through a literature review, we explore recent advancements in traditional Chinese medicine (TCM) aimed at reducing RF and inhibiting chronic kidney disease (CKD). We summarize, analyze, and elaborate on the important role of Chinese herbs in RF, aiming to provide new directions for their application in prevention and treatment, as well as scientific guidance for clinical practices.https://www.frontiersin.org/articles/10.3389/fphar.2024.1403227/fullrenal fibrosischronic kidney diseasepathogenesissignaling pathwaystraditional Chinese medicinetreatment |
| spellingShingle | Lijuan Liang Lijuan Liang Youjun Mi Shihan Zhou Aojian Yang Chaoyu Wei Enlai Dai Advances in the study of key cells and signaling pathways in renal fibrosis and the interventional role of Chinese medicines Frontiers in Pharmacology renal fibrosis chronic kidney disease pathogenesis signaling pathways traditional Chinese medicine treatment |
| title | Advances in the study of key cells and signaling pathways in renal fibrosis and the interventional role of Chinese medicines |
| title_full | Advances in the study of key cells and signaling pathways in renal fibrosis and the interventional role of Chinese medicines |
| title_fullStr | Advances in the study of key cells and signaling pathways in renal fibrosis and the interventional role of Chinese medicines |
| title_full_unstemmed | Advances in the study of key cells and signaling pathways in renal fibrosis and the interventional role of Chinese medicines |
| title_short | Advances in the study of key cells and signaling pathways in renal fibrosis and the interventional role of Chinese medicines |
| title_sort | advances in the study of key cells and signaling pathways in renal fibrosis and the interventional role of chinese medicines |
| topic | renal fibrosis chronic kidney disease pathogenesis signaling pathways traditional Chinese medicine treatment |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1403227/full |
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