Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis?
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the degeneration of both upper and lower motor neurons. Patients show both motor and extra-motor symptoms. A cure is not available at this time, and the disease leads to death within 3–5 years, mainly due to respirat...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/3675627 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549317897879552 |
|---|---|
| author | Agnese Gugliandolo Placido Bramanti Emanuela Mazzon |
| author_facet | Agnese Gugliandolo Placido Bramanti Emanuela Mazzon |
| author_sort | Agnese Gugliandolo |
| collection | DOAJ |
| description | Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the degeneration of both upper and lower motor neurons. Patients show both motor and extra-motor symptoms. A cure is not available at this time, and the disease leads to death within 3–5 years, mainly due to respiratory failure. Stem cell therapy is arising as a new promising approach for the treatment of neurodegenerative disorders. In particular, mesenchymal stem cells (MSCs) seem the most suitable type of stem cells, thanks to their demonstrated beneficial effects in different experimental models, to the easy availability, and to the lack of ethical problems. In this review, we focused on the studies involving ALS rodent models and clinical trials in order to understand the potential beneficial effects of MSC transplantation. In different ALS rodent models, the administration of MSCs induced a delay in disease progression and at least a partial recovery of the motor function. In addition, clinical trials evidenced the feasibility and safety of MSC transplantation in ALS patients, given that no major adverse events were recorded. However, only partial improvements were shown. For this reason, more studies and trials are needed to clarify the real effectiveness of MSC-based therapy in ALS. |
| format | Article |
| id | doaj-art-8dc2901deb464684a30210e03a6426bb |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-8dc2901deb464684a30210e03a6426bb2025-02-03T06:11:32ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/36756273675627Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis?Agnese Gugliandolo0Placido Bramanti1Emanuela Mazzon2IRCCS Centro Neurolesi “Bonino Pulejo”, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino Pulejo”, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino Pulejo”, 98124 Messina, ItalyAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the degeneration of both upper and lower motor neurons. Patients show both motor and extra-motor symptoms. A cure is not available at this time, and the disease leads to death within 3–5 years, mainly due to respiratory failure. Stem cell therapy is arising as a new promising approach for the treatment of neurodegenerative disorders. In particular, mesenchymal stem cells (MSCs) seem the most suitable type of stem cells, thanks to their demonstrated beneficial effects in different experimental models, to the easy availability, and to the lack of ethical problems. In this review, we focused on the studies involving ALS rodent models and clinical trials in order to understand the potential beneficial effects of MSC transplantation. In different ALS rodent models, the administration of MSCs induced a delay in disease progression and at least a partial recovery of the motor function. In addition, clinical trials evidenced the feasibility and safety of MSC transplantation in ALS patients, given that no major adverse events were recorded. However, only partial improvements were shown. For this reason, more studies and trials are needed to clarify the real effectiveness of MSC-based therapy in ALS.http://dx.doi.org/10.1155/2019/3675627 |
| spellingShingle | Agnese Gugliandolo Placido Bramanti Emanuela Mazzon Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis? Stem Cells International |
| title | Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis? |
| title_full | Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis? |
| title_fullStr | Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis? |
| title_full_unstemmed | Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis? |
| title_short | Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis? |
| title_sort | mesenchymal stem cells a potential therapeutic approach for amyotrophic lateral sclerosis |
| url | http://dx.doi.org/10.1155/2019/3675627 |
| work_keys_str_mv | AT agnesegugliandolo mesenchymalstemcellsapotentialtherapeuticapproachforamyotrophiclateralsclerosis AT placidobramanti mesenchymalstemcellsapotentialtherapeuticapproachforamyotrophiclateralsclerosis AT emanuelamazzon mesenchymalstemcellsapotentialtherapeuticapproachforamyotrophiclateralsclerosis |