Comparison of thermal ablation and surgery for hyperparathyroidism: a meta-analysis
Objective Surgery and thermal ablation are both viable treatment modalities for patients diagnosed with hyperparathyroidism (HPT). However, the comparative efficacy of these approaches remains uncertain. The objective of this meta-analysis is to evaluate the effectiveness of surgical complications a...
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Taylor & Francis Group
2025-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2441402 |
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| author | Huan-yu Cui Xiu-mei Bai Hong Yang Yun He |
| author_facet | Huan-yu Cui Xiu-mei Bai Hong Yang Yun He |
| author_sort | Huan-yu Cui |
| collection | DOAJ |
| description | Objective Surgery and thermal ablation are both viable treatment modalities for patients diagnosed with hyperparathyroidism (HPT). However, the comparative efficacy of these approaches remains uncertain. The objective of this meta-analysis is to evaluate the effectiveness of surgical complications and therapeutic strategies in managing HPT.Methods The databases PubMed, EMBASE, the Cochrane Library, the Web of Science, CNKI and Wan Fang were systematically searched from inception to December 12, 2023 to identify relevant studies comparing thermal ablation with surgical parathyroid hormone therapy. Data analysis was conducted using Review Manager Version 5.4.Result A total of 15 studies were incorporated into the meta-analysis, comprising 1,115 participants drawn from 12 cohort studies and three randomized controlled trials. The results indicated no significant difference in parathyroid hormone levels between the two treatment options (mean difference: 29.25, 95% CI: −4.99–63.69, p = 0.09), calcium (MD: 0.00, 95%CI: 0.07–0.08, p = 0.94), phosphorus (MD: −0.05, 95% CI: −0.13–0.04, p = 0.28) and the risk of persistence and/or recurrence (OR: 1.01, 95% CI: 0.63–1.62, p = 0.97). The probability of hoarseness (OR: 0.57, 95% CI: 0.35–0.93, p = 0.02) and hypocalcemia (OR: −0.12, 95% CI: −0.19- −0.05, p < 0.01) was lower after thermal ablation than with surgery. Comparable results were observed in instances of secondary and primary hyperparathyroidism.Conclusion It can be concluded that surgery and thermal ablation are effective modalities for treating hyperparathyroidism. Thermal ablation has been shown to reduce the likelihood of hoarseness and hypocalcemia. Further validation of these results necessitates conducting comprehensive multicenter randomized controlled trials. |
| format | Article |
| id | doaj-art-8dc205ad8af24b78a129cf160eff8f92 |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-8dc205ad8af24b78a129cf160eff8f922025-01-28T01:13:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572025-12-0142110.1080/02656736.2024.2441402Comparison of thermal ablation and surgery for hyperparathyroidism: a meta-analysisHuan-yu Cui0Xiu-mei Bai1Hong Yang2Yun He3Department of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaObjective Surgery and thermal ablation are both viable treatment modalities for patients diagnosed with hyperparathyroidism (HPT). However, the comparative efficacy of these approaches remains uncertain. The objective of this meta-analysis is to evaluate the effectiveness of surgical complications and therapeutic strategies in managing HPT.Methods The databases PubMed, EMBASE, the Cochrane Library, the Web of Science, CNKI and Wan Fang were systematically searched from inception to December 12, 2023 to identify relevant studies comparing thermal ablation with surgical parathyroid hormone therapy. Data analysis was conducted using Review Manager Version 5.4.Result A total of 15 studies were incorporated into the meta-analysis, comprising 1,115 participants drawn from 12 cohort studies and three randomized controlled trials. The results indicated no significant difference in parathyroid hormone levels between the two treatment options (mean difference: 29.25, 95% CI: −4.99–63.69, p = 0.09), calcium (MD: 0.00, 95%CI: 0.07–0.08, p = 0.94), phosphorus (MD: −0.05, 95% CI: −0.13–0.04, p = 0.28) and the risk of persistence and/or recurrence (OR: 1.01, 95% CI: 0.63–1.62, p = 0.97). The probability of hoarseness (OR: 0.57, 95% CI: 0.35–0.93, p = 0.02) and hypocalcemia (OR: −0.12, 95% CI: −0.19- −0.05, p < 0.01) was lower after thermal ablation than with surgery. Comparable results were observed in instances of secondary and primary hyperparathyroidism.Conclusion It can be concluded that surgery and thermal ablation are effective modalities for treating hyperparathyroidism. Thermal ablation has been shown to reduce the likelihood of hoarseness and hypocalcemia. Further validation of these results necessitates conducting comprehensive multicenter randomized controlled trials.https://www.tandfonline.com/doi/10.1080/02656736.2024.2441402Hyperparathyroidismthermal ablationsurgerytherapymeta-analysis |
| spellingShingle | Huan-yu Cui Xiu-mei Bai Hong Yang Yun He Comparison of thermal ablation and surgery for hyperparathyroidism: a meta-analysis International Journal of Hyperthermia Hyperparathyroidism thermal ablation surgery therapy meta-analysis |
| title | Comparison of thermal ablation and surgery for hyperparathyroidism: a meta-analysis |
| title_full | Comparison of thermal ablation and surgery for hyperparathyroidism: a meta-analysis |
| title_fullStr | Comparison of thermal ablation and surgery for hyperparathyroidism: a meta-analysis |
| title_full_unstemmed | Comparison of thermal ablation and surgery for hyperparathyroidism: a meta-analysis |
| title_short | Comparison of thermal ablation and surgery for hyperparathyroidism: a meta-analysis |
| title_sort | comparison of thermal ablation and surgery for hyperparathyroidism a meta analysis |
| topic | Hyperparathyroidism thermal ablation surgery therapy meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2441402 |
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