Heterologous prime-boost immunization combining parenteral and mucosal routes with different adjuvants mounts long-lived CD4+ T cell responses in lungs

Heterologous prime-boost immunization combining parenteral and mucosal routes with different adjuvants mounts long-lived CD4+ T cell responses in lungs

IntroductionAirway mucosa represents the main entry point for several human pathogens, and as such vaccines against respiratory diseases should ideally elicit protective immune responses in the airways. We have previously reported two immunomodulatory adjuvants based on non-toxic derivatives of Chol...

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Bibliographic Details
Main Authors: Ranmali Kavishna, Thorunn Asta Olafsdottir, Siggeir F. Brynjólfsson, Dennis Christensen, Tobias Gustafsson-Hedberg, Peter Andersen, Manuela Terrinoni, Jan Holmgren, Ali M. Harandi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
adjuvants
prime-boost immunization
parenteral route
mucosal route
T cell response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1599713/full
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