A prospective multicenter phase III clinical trial evaluating the efficacy and safety of silk elastin sponge in patients with skin defects

A prospective multicenter phase III clinical trial evaluating the efficacy and safety of silk elastin sponge in patients with skin defects

Abstract Silk elastin sponge, a novel recombinant protein used for wound healing, has been shown to be effective in promoting macrophage migration, epithelial growth, granulation, and angiogenesis in both preclinical (in vitro and in vivo) and clinical studies. This study aimed to evaluate the effic...

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Bibliographic Details
Main Authors: Eiichi Sawaragi, Michiharu Sakamoto, Yasuhiro Katayama, Shingo Kawabata, Satoshi Somamoto, Kazuo Noda, Naoki Morimoto
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Wound healing
Recombinant protein
Silk-elastin sponge
Chronic wound
Acute wound
Clinical trial
Online Access:https://doi.org/10.1038/s41598-025-88150-w
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