Extracellular bioelectrical lexicon: detecting rhythmic patterns within dermal fibroblast populations
Abstract This study uses a bioelectronic-based method to establish how non-electrogenic cells, like dermal fibroblast, employ bioelectrical signals to convey information. Electrophysiology using large-area Multielectrode Arrays (MEAs) devices revealed how populations of non-electrogenic cells in vit...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-15071-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849237862163152896 |
|---|---|
| author | Rute C. Félix Maria C. Medeiros Youssef Elamine Deborah M. Power Henrique Leonel Gomes |
| author_facet | Rute C. Félix Maria C. Medeiros Youssef Elamine Deborah M. Power Henrique Leonel Gomes |
| author_sort | Rute C. Félix |
| collection | DOAJ |
| description | Abstract This study uses a bioelectronic-based method to establish how non-electrogenic cells, like dermal fibroblast, employ bioelectrical signals to convey information. Electrophysiology using large-area Multielectrode Arrays (MEAs) devices revealed how populations of non-electrogenic cells in vitro generate patterns of bioelectrical signals. The period of the bioelectrical patterns depends on cell population activity. In a fully formed, healthy monolayer, bioelectrical activity is minimal. But during the formation of a monolayer, signals appear randomly, with a dominant period of 4.2 min. Occasionally, quasi-periodic bursts occur with a period between 1.6 and 2 min. When a mechanical wound is inflicted and during subsequent monolayer repair, quasi-periodic signal bursts occur, with an average period ranging from 60 to 110 min. The study uncovers a short-range non humoral communication system and a lexicon of bioelectrical signals linked to cell states. |
| format | Article |
| id | doaj-art-8db928abcf754d61a07f9f4c80c8ab7c |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-8db928abcf754d61a07f9f4c80c8ab7c2025-08-20T04:01:51ZengNature PortfolioScientific Reports2045-23222025-08-0115111110.1038/s41598-025-15071-zExtracellular bioelectrical lexicon: detecting rhythmic patterns within dermal fibroblast populationsRute C. Félix0Maria C. Medeiros1Youssef Elamine2Deborah M. Power3Henrique Leonel Gomes4Centro de Ciências do Mar (CCMAR/CIMAR), Universidade do AlgarveDepartamento de Engenharia Electrotécnica e de Computadores, Instituto de TelecomunicaçõesDepartamento de Engenharia Electrotécnica e de Computadores, Instituto de TelecomunicaçõesCentro de Ciências do Mar (CCMAR/CIMAR), Universidade do AlgarveDepartamento de Engenharia Electrotécnica e de Computadores, Instituto de TelecomunicaçõesAbstract This study uses a bioelectronic-based method to establish how non-electrogenic cells, like dermal fibroblast, employ bioelectrical signals to convey information. Electrophysiology using large-area Multielectrode Arrays (MEAs) devices revealed how populations of non-electrogenic cells in vitro generate patterns of bioelectrical signals. The period of the bioelectrical patterns depends on cell population activity. In a fully formed, healthy monolayer, bioelectrical activity is minimal. But during the formation of a monolayer, signals appear randomly, with a dominant period of 4.2 min. Occasionally, quasi-periodic bursts occur with a period between 1.6 and 2 min. When a mechanical wound is inflicted and during subsequent monolayer repair, quasi-periodic signal bursts occur, with an average period ranging from 60 to 110 min. The study uncovers a short-range non humoral communication system and a lexicon of bioelectrical signals linked to cell states.https://doi.org/10.1038/s41598-025-15071-zElectrophysiologyNon-excitable cellsExtra-cellular electrodesBioelectricityFibroblasts |
| spellingShingle | Rute C. Félix Maria C. Medeiros Youssef Elamine Deborah M. Power Henrique Leonel Gomes Extracellular bioelectrical lexicon: detecting rhythmic patterns within dermal fibroblast populations Scientific Reports Electrophysiology Non-excitable cells Extra-cellular electrodes Bioelectricity Fibroblasts |
| title | Extracellular bioelectrical lexicon: detecting rhythmic patterns within dermal fibroblast populations |
| title_full | Extracellular bioelectrical lexicon: detecting rhythmic patterns within dermal fibroblast populations |
| title_fullStr | Extracellular bioelectrical lexicon: detecting rhythmic patterns within dermal fibroblast populations |
| title_full_unstemmed | Extracellular bioelectrical lexicon: detecting rhythmic patterns within dermal fibroblast populations |
| title_short | Extracellular bioelectrical lexicon: detecting rhythmic patterns within dermal fibroblast populations |
| title_sort | extracellular bioelectrical lexicon detecting rhythmic patterns within dermal fibroblast populations |
| topic | Electrophysiology Non-excitable cells Extra-cellular electrodes Bioelectricity Fibroblasts |
| url | https://doi.org/10.1038/s41598-025-15071-z |
| work_keys_str_mv | AT rutecfelix extracellularbioelectricallexicondetectingrhythmicpatternswithindermalfibroblastpopulations AT mariacmedeiros extracellularbioelectricallexicondetectingrhythmicpatternswithindermalfibroblastpopulations AT youssefelamine extracellularbioelectricallexicondetectingrhythmicpatternswithindermalfibroblastpopulations AT deborahmpower extracellularbioelectricallexicondetectingrhythmicpatternswithindermalfibroblastpopulations AT henriqueleonelgomes extracellularbioelectricallexicondetectingrhythmicpatternswithindermalfibroblastpopulations |