Health outcome measures in atopic dermatitis: a systematic review of trends in disease severity and quality-of-life instruments 1985-2010.
<h4>Background</h4>A number of disease-severity and quality-of-life (QoL) instruments have emerged in atopic dermatitis (AD) in the last decade.<h4>Objectives</h4>To identify trends in outcomes instruments used in AD clinical trials and to provide a useful summary of the dime...
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Public Library of Science (PLoS)
2011-04-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0017520&type=printable |
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| author | Balvinder Rehal April W Armstrong |
| author_facet | Balvinder Rehal April W Armstrong |
| author_sort | Balvinder Rehal |
| collection | DOAJ |
| description | <h4>Background</h4>A number of disease-severity and quality-of-life (QoL) instruments have emerged in atopic dermatitis (AD) in the last decade.<h4>Objectives</h4>To identify trends in outcomes instruments used in AD clinical trials and to provide a useful summary of the dimensions and validation studies for the most commonly used measures.<h4>Method</h4>All randomized control trials (RCTs) from 1985 to 2010 in the treatment of AD were examined.<h4>Results</h4>Among the 791 RCTs reviewed, we identified 20 disease-severity and 14 QoL instruments. Of these outcomes instruments, few have been validated. SCORAD, EASI, IGA and SASSAD were the most commonly used disease-severity instruments and CDLQI, DFI, DLQI and IDQOL were the most frequently used QoL measures.<h4>Limitations</h4>The small number of RCTs using QoL scales makes identifying trends for QoL instruments difficult.<h4>Conclusion</h4>Overall, there is an increase in the use of disease-severity and QoL instruments in AD clinical trials. |
| format | Article |
| id | doaj-art-8db3ed5ed0054f259796664e75fa425b |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2011-04-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-8db3ed5ed0054f259796664e75fa425b2025-08-20T02:37:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-04-0164e1752010.1371/journal.pone.0017520Health outcome measures in atopic dermatitis: a systematic review of trends in disease severity and quality-of-life instruments 1985-2010.Balvinder RehalApril W Armstrong<h4>Background</h4>A number of disease-severity and quality-of-life (QoL) instruments have emerged in atopic dermatitis (AD) in the last decade.<h4>Objectives</h4>To identify trends in outcomes instruments used in AD clinical trials and to provide a useful summary of the dimensions and validation studies for the most commonly used measures.<h4>Method</h4>All randomized control trials (RCTs) from 1985 to 2010 in the treatment of AD were examined.<h4>Results</h4>Among the 791 RCTs reviewed, we identified 20 disease-severity and 14 QoL instruments. Of these outcomes instruments, few have been validated. SCORAD, EASI, IGA and SASSAD were the most commonly used disease-severity instruments and CDLQI, DFI, DLQI and IDQOL were the most frequently used QoL measures.<h4>Limitations</h4>The small number of RCTs using QoL scales makes identifying trends for QoL instruments difficult.<h4>Conclusion</h4>Overall, there is an increase in the use of disease-severity and QoL instruments in AD clinical trials.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0017520&type=printable |
| spellingShingle | Balvinder Rehal April W Armstrong Health outcome measures in atopic dermatitis: a systematic review of trends in disease severity and quality-of-life instruments 1985-2010. PLoS ONE |
| title | Health outcome measures in atopic dermatitis: a systematic review of trends in disease severity and quality-of-life instruments 1985-2010. |
| title_full | Health outcome measures in atopic dermatitis: a systematic review of trends in disease severity and quality-of-life instruments 1985-2010. |
| title_fullStr | Health outcome measures in atopic dermatitis: a systematic review of trends in disease severity and quality-of-life instruments 1985-2010. |
| title_full_unstemmed | Health outcome measures in atopic dermatitis: a systematic review of trends in disease severity and quality-of-life instruments 1985-2010. |
| title_short | Health outcome measures in atopic dermatitis: a systematic review of trends in disease severity and quality-of-life instruments 1985-2010. |
| title_sort | health outcome measures in atopic dermatitis a systematic review of trends in disease severity and quality of life instruments 1985 2010 |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0017520&type=printable |
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