Health outcome measures in atopic dermatitis: a systematic review of trends in disease severity and quality-of-life instruments 1985-2010.
<h4>Background</h4>A number of disease-severity and quality-of-life (QoL) instruments have emerged in atopic dermatitis (AD) in the last decade.<h4>Objectives</h4>To identify trends in outcomes instruments used in AD clinical trials and to provide a useful summary of the dime...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-04-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0017520&type=printable |
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| Summary: | <h4>Background</h4>A number of disease-severity and quality-of-life (QoL) instruments have emerged in atopic dermatitis (AD) in the last decade.<h4>Objectives</h4>To identify trends in outcomes instruments used in AD clinical trials and to provide a useful summary of the dimensions and validation studies for the most commonly used measures.<h4>Method</h4>All randomized control trials (RCTs) from 1985 to 2010 in the treatment of AD were examined.<h4>Results</h4>Among the 791 RCTs reviewed, we identified 20 disease-severity and 14 QoL instruments. Of these outcomes instruments, few have been validated. SCORAD, EASI, IGA and SASSAD were the most commonly used disease-severity instruments and CDLQI, DFI, DLQI and IDQOL were the most frequently used QoL measures.<h4>Limitations</h4>The small number of RCTs using QoL scales makes identifying trends for QoL instruments difficult.<h4>Conclusion</h4>Overall, there is an increase in the use of disease-severity and QoL instruments in AD clinical trials. |
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| ISSN: | 1932-6203 |