Risk Factors Associated with Increased Morbidity in Living Liver Donation
Living donor liver donation (LDLD) is an alternative to cadaveric liver donation. We aimed at identifying risk factors and developing a score for prediction of postoperative complications (POCs) after LDLD in donors. This is a retrospective cohort study in 688 donors between June 1995 and February 2...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2015/949674 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850210789102714880 |
|---|---|
| author | Helry L. Candido Eduardo A. da Fonseca Flávia H. Feier Renata Pugliese Marcel A. Benavides Enis D. Silva Karina Gordon Marcelo Gama de Abreu Jaume Canet Paulo Chapchap Joao Seda Neto |
| author_facet | Helry L. Candido Eduardo A. da Fonseca Flávia H. Feier Renata Pugliese Marcel A. Benavides Enis D. Silva Karina Gordon Marcelo Gama de Abreu Jaume Canet Paulo Chapchap Joao Seda Neto |
| author_sort | Helry L. Candido |
| collection | DOAJ |
| description | Living donor liver donation (LDLD) is an alternative to cadaveric liver donation. We aimed at identifying risk factors and developing a score for prediction of postoperative complications (POCs) after LDLD in donors. This is a retrospective cohort study in 688 donors between June 1995 and February 2014 at Hospital Sírio-Libanês and A.C. Camargo Cancer Center, in São Paulo, Brazil. Primary outcome was POC graded ≥III according to the Clavien-Dindo classification. Left lateral segment (LLS), left lobe (LL), and right lobe resections (RL) were conducted in 492 (71.4%), 109 (15.8%), and 87 (12.6%) donors, respectively. In total, 43 (6.2%) developed POCs, which were more common after RL than LLS and LL (14/87 (16.1%) versus 23/492 (4.5%) and 6/109 (5.5%), resp., p<0.001). Multivariate analysis showed that RL resection (OR: 2.81, 95% CI: 1.32 to 3.01; p=0.008), smoking status (OR: 3.2, 95% CI: 1.35 to 7.56; p=0.012), and blood transfusion (OR: 3.15, 95% CI: 1.45 to 6.84; p=0.004) were independently associated with POCs. RL resection, intraoperative blood transfusion, and smoking were associated with increased risk for POCs in donors. |
| format | Article |
| id | doaj-art-8db3d9e234da451aa8ee1440469e2919 |
| institution | OA Journals |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-8db3d9e234da451aa8ee1440469e29192025-08-20T02:09:41ZengWileyJournal of Transplantation2090-00072090-00152015-01-01201510.1155/2015/949674949674Risk Factors Associated with Increased Morbidity in Living Liver DonationHelry L. Candido0Eduardo A. da Fonseca1Flávia H. Feier2Renata Pugliese3Marcel A. Benavides4Enis D. Silva5Karina Gordon6Marcelo Gama de Abreu7Jaume Canet8Paulo Chapchap9Joao Seda Neto10Hepatology and Liver Transplantation, Hospital Sírio-Libanês, Rua Barata Ribeiro 414, cj 65, 01308-000 Bela Vista, SP, BrazilHepatology and Liver Transplantation, Hospital Sírio-Libanês, Rua Barata Ribeiro 414, cj 65, 01308-000 Bela Vista, SP, BrazilHepatology and Liver Transplantation, Hospital Sírio-Libanês, Rua Barata Ribeiro 414, cj 65, 01308-000 Bela Vista, SP, BrazilHepatology and Liver Transplantation, Hospital Sírio-Libanês, Rua Barata Ribeiro 414, cj 65, 01308-000 Bela Vista, SP, BrazilHepatology and Liver Transplantation, Hospital Sírio-Libanês, Rua Barata Ribeiro 414, cj 65, 01308-000 Bela Vista, SP, BrazilDepartment of Anesthesiology, Hospital Sírio-Libanês, Rua Barata Ribeiro 414, cj 65, 01308-000 Bela Vista, SP, BrazilDepartment of Anesthesiology, A.C. Camargo Cancer Center, São Paulo, BrazilDepartment of Anesthesiology and Intensive Care Therapy, Pulmonary Engineering Group, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, GermanyDepartment of Anesthesiology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, SpainHepatology and Liver Transplantation, Hospital Sírio-Libanês, Rua Barata Ribeiro 414, cj 65, 01308-000 Bela Vista, SP, BrazilHepatology and Liver Transplantation, Hospital Sírio-Libanês, Rua Barata Ribeiro 414, cj 65, 01308-000 Bela Vista, SP, BrazilLiving donor liver donation (LDLD) is an alternative to cadaveric liver donation. We aimed at identifying risk factors and developing a score for prediction of postoperative complications (POCs) after LDLD in donors. This is a retrospective cohort study in 688 donors between June 1995 and February 2014 at Hospital Sírio-Libanês and A.C. Camargo Cancer Center, in São Paulo, Brazil. Primary outcome was POC graded ≥III according to the Clavien-Dindo classification. Left lateral segment (LLS), left lobe (LL), and right lobe resections (RL) were conducted in 492 (71.4%), 109 (15.8%), and 87 (12.6%) donors, respectively. In total, 43 (6.2%) developed POCs, which were more common after RL than LLS and LL (14/87 (16.1%) versus 23/492 (4.5%) and 6/109 (5.5%), resp., p<0.001). Multivariate analysis showed that RL resection (OR: 2.81, 95% CI: 1.32 to 3.01; p=0.008), smoking status (OR: 3.2, 95% CI: 1.35 to 7.56; p=0.012), and blood transfusion (OR: 3.15, 95% CI: 1.45 to 6.84; p=0.004) were independently associated with POCs. RL resection, intraoperative blood transfusion, and smoking were associated with increased risk for POCs in donors.http://dx.doi.org/10.1155/2015/949674 |
| spellingShingle | Helry L. Candido Eduardo A. da Fonseca Flávia H. Feier Renata Pugliese Marcel A. Benavides Enis D. Silva Karina Gordon Marcelo Gama de Abreu Jaume Canet Paulo Chapchap Joao Seda Neto Risk Factors Associated with Increased Morbidity in Living Liver Donation Journal of Transplantation |
| title | Risk Factors Associated with Increased Morbidity in Living Liver Donation |
| title_full | Risk Factors Associated with Increased Morbidity in Living Liver Donation |
| title_fullStr | Risk Factors Associated with Increased Morbidity in Living Liver Donation |
| title_full_unstemmed | Risk Factors Associated with Increased Morbidity in Living Liver Donation |
| title_short | Risk Factors Associated with Increased Morbidity in Living Liver Donation |
| title_sort | risk factors associated with increased morbidity in living liver donation |
| url | http://dx.doi.org/10.1155/2015/949674 |
| work_keys_str_mv | AT helrylcandido riskfactorsassociatedwithincreasedmorbidityinlivingliverdonation AT eduardoadafonseca riskfactorsassociatedwithincreasedmorbidityinlivingliverdonation AT flaviahfeier riskfactorsassociatedwithincreasedmorbidityinlivingliverdonation AT renatapugliese riskfactorsassociatedwithincreasedmorbidityinlivingliverdonation AT marcelabenavides riskfactorsassociatedwithincreasedmorbidityinlivingliverdonation AT enisdsilva riskfactorsassociatedwithincreasedmorbidityinlivingliverdonation AT karinagordon riskfactorsassociatedwithincreasedmorbidityinlivingliverdonation AT marcelogamadeabreu riskfactorsassociatedwithincreasedmorbidityinlivingliverdonation AT jaumecanet riskfactorsassociatedwithincreasedmorbidityinlivingliverdonation AT paulochapchap riskfactorsassociatedwithincreasedmorbidityinlivingliverdonation AT joaosedaneto riskfactorsassociatedwithincreasedmorbidityinlivingliverdonation |