Metabolic reprogramming and renal fibrosis: what role might Chinese medicine play?
Abstract Metabolic reprogramming is a pivotal biological process in which cellular metabolic patterns change to meet the energy demands of increased cell growth and proliferation. In this review, we explore metabolic reprogramming and its impact on fibrotic diseases, providing a detailed overview of...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-10-01
|
| Series: | Chinese Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13020-024-01004-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850179389716692992 |
|---|---|
| author | Weili Wang Rong Dai Meng Cheng Yizhen Chen Yilin Gao Xin Hong Wei Zhang Yiping Wang Lei Zhang |
| author_facet | Weili Wang Rong Dai Meng Cheng Yizhen Chen Yilin Gao Xin Hong Wei Zhang Yiping Wang Lei Zhang |
| author_sort | Weili Wang |
| collection | DOAJ |
| description | Abstract Metabolic reprogramming is a pivotal biological process in which cellular metabolic patterns change to meet the energy demands of increased cell growth and proliferation. In this review, we explore metabolic reprogramming and its impact on fibrotic diseases, providing a detailed overview of the key processes involved in the metabolic reprogramming of renal fibrosis, including fatty acid decomposition and synthesis, glycolysis, and amino acid catabolism. In addition, we report that Chinese medicine ameliorates renal inflammation, oxidative stress, and apoptosis in chronic kidney disease by regulating metabolic processes, thereby inhibiting renal fibrosis. Furthermore, we reveal that multiple targets and signaling pathways contribute to the metabolic regulatory effects of Chinese medicine. In summary, this review aims to elucidate the mechanisms by which Chinese medicine inhibits renal fibrosis through the remodeling of renal cell metabolic processes, with the goal of discovering new therapeutic drugs for treating renal fibrosis. |
| format | Article |
| id | doaj-art-8db2b08e4fd9403692efdf6de951dcd0 |
| institution | OA Journals |
| issn | 1749-8546 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Medicine |
| spelling | doaj-art-8db2b08e4fd9403692efdf6de951dcd02025-08-20T02:18:31ZengBMCChinese Medicine1749-85462024-10-0119112210.1186/s13020-024-01004-xMetabolic reprogramming and renal fibrosis: what role might Chinese medicine play?Weili Wang0Rong Dai1Meng Cheng2Yizhen Chen3Yilin Gao4Xin Hong5Wei Zhang6Yiping Wang7Lei Zhang8First Clinical Medical College, Anhui University of Chinese MedicineDepartment of Nephrology, The First Affiliated Hospital of Anhui University of Chinese MedicineDepartment of Nephrology, The First Affiliated Hospital of Anhui University of Chinese MedicineFirst Clinical Medical College, Anhui University of Chinese MedicineFirst Clinical Medical College, Anhui University of Chinese MedicineFirst Clinical Medical College, Anhui University of Chinese MedicineFirst Clinical Medical College, Anhui University of Chinese MedicineDepartment of Nephrology, The First Affiliated Hospital of Anhui University of Chinese MedicineDepartment of Nephrology, The First Affiliated Hospital of Anhui University of Chinese MedicineAbstract Metabolic reprogramming is a pivotal biological process in which cellular metabolic patterns change to meet the energy demands of increased cell growth and proliferation. In this review, we explore metabolic reprogramming and its impact on fibrotic diseases, providing a detailed overview of the key processes involved in the metabolic reprogramming of renal fibrosis, including fatty acid decomposition and synthesis, glycolysis, and amino acid catabolism. In addition, we report that Chinese medicine ameliorates renal inflammation, oxidative stress, and apoptosis in chronic kidney disease by regulating metabolic processes, thereby inhibiting renal fibrosis. Furthermore, we reveal that multiple targets and signaling pathways contribute to the metabolic regulatory effects of Chinese medicine. In summary, this review aims to elucidate the mechanisms by which Chinese medicine inhibits renal fibrosis through the remodeling of renal cell metabolic processes, with the goal of discovering new therapeutic drugs for treating renal fibrosis.https://doi.org/10.1186/s13020-024-01004-xChinese medicineMetabolic reprogrammingRenal fibrosis |
| spellingShingle | Weili Wang Rong Dai Meng Cheng Yizhen Chen Yilin Gao Xin Hong Wei Zhang Yiping Wang Lei Zhang Metabolic reprogramming and renal fibrosis: what role might Chinese medicine play? Chinese Medicine Chinese medicine Metabolic reprogramming Renal fibrosis |
| title | Metabolic reprogramming and renal fibrosis: what role might Chinese medicine play? |
| title_full | Metabolic reprogramming and renal fibrosis: what role might Chinese medicine play? |
| title_fullStr | Metabolic reprogramming and renal fibrosis: what role might Chinese medicine play? |
| title_full_unstemmed | Metabolic reprogramming and renal fibrosis: what role might Chinese medicine play? |
| title_short | Metabolic reprogramming and renal fibrosis: what role might Chinese medicine play? |
| title_sort | metabolic reprogramming and renal fibrosis what role might chinese medicine play |
| topic | Chinese medicine Metabolic reprogramming Renal fibrosis |
| url | https://doi.org/10.1186/s13020-024-01004-x |
| work_keys_str_mv | AT weiliwang metabolicreprogrammingandrenalfibrosiswhatrolemightchinesemedicineplay AT rongdai metabolicreprogrammingandrenalfibrosiswhatrolemightchinesemedicineplay AT mengcheng metabolicreprogrammingandrenalfibrosiswhatrolemightchinesemedicineplay AT yizhenchen metabolicreprogrammingandrenalfibrosiswhatrolemightchinesemedicineplay AT yilingao metabolicreprogrammingandrenalfibrosiswhatrolemightchinesemedicineplay AT xinhong metabolicreprogrammingandrenalfibrosiswhatrolemightchinesemedicineplay AT weizhang metabolicreprogrammingandrenalfibrosiswhatrolemightchinesemedicineplay AT yipingwang metabolicreprogrammingandrenalfibrosiswhatrolemightchinesemedicineplay AT leizhang metabolicreprogrammingandrenalfibrosiswhatrolemightchinesemedicineplay |