Enhancing genomic prediction in Arabidopsis thaliana with optimized SNP subset by leveraging gene ontology priors and bin-based combinatorial optimization
With the rapid development of high-density molecular marker chips and high-throughput sequencing technologies, genomic selection/prediction (GS/GP) has been widely applied in plant breeding. Arabidopsis thaliana, as a common model organism, provides important resources for dissecting genetic variati...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
|
| Series: | Frontiers in Bioinformatics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbinf.2025.1607119/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850118494286249984 |
|---|---|
| author | Qingfang Ba Heng Zhou Zheming Yuan Zhijun Dai |
| author_facet | Qingfang Ba Heng Zhou Zheming Yuan Zhijun Dai |
| author_sort | Qingfang Ba |
| collection | DOAJ |
| description | With the rapid development of high-density molecular marker chips and high-throughput sequencing technologies, genomic selection/prediction (GS/GP) has been widely applied in plant breeding. Arabidopsis thaliana, as a common model organism, provides important resources for dissecting genetic variation and evolutionary mechanisms of complex traits. Quantitative traits are typically influenced by multiple minor-effect genes, which are often functionally related and can be enriched within gene ontology (GO) pathways. However, optimizing marker subsets associated with these pathways to enhance GP performance remains challenging. In this study, we propose an improved GS framework called binGO-GS by integrating GO-based biological priors with a novel bin-based combinatorial SNP subset selection strategy. We evaluated the performance of binGO-GS on nine quantitative traits from two A. thaliana datasets, comprising nearly 1,000 samples and over 1.8 million SNPs. Compared with using either the full marker set or randomly selected markers with Genomic BLUP (GBLUP), binGO-GS achieved statistically significant improvements in prediction accuracy across all traits. Similar improvements were observed across six additional regression models when applying binGO-GS instead of the full marker set. Furthermore, the selected markers for identical or similar morphological traits exhibited consistent patterns in quantity and genomic distribution, supporting the polygenic model of complex quantitative traits driven by minor-effect genes. Taken together, binGO-GS offers a powerful and interpretable approach to enhance GS performance, providing a methodological reference for accelerating plant breeding and germplasm innovation. |
| format | Article |
| id | doaj-art-8daa370a8b3f49f0a5f4e6ba0e924995 |
| institution | OA Journals |
| issn | 2673-7647 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioinformatics |
| spelling | doaj-art-8daa370a8b3f49f0a5f4e6ba0e9249952025-08-20T02:35:51ZengFrontiers Media S.A.Frontiers in Bioinformatics2673-76472025-06-01510.3389/fbinf.2025.16071191607119Enhancing genomic prediction in Arabidopsis thaliana with optimized SNP subset by leveraging gene ontology priors and bin-based combinatorial optimizationQingfang BaHeng ZhouZheming YuanZhijun DaiWith the rapid development of high-density molecular marker chips and high-throughput sequencing technologies, genomic selection/prediction (GS/GP) has been widely applied in plant breeding. Arabidopsis thaliana, as a common model organism, provides important resources for dissecting genetic variation and evolutionary mechanisms of complex traits. Quantitative traits are typically influenced by multiple minor-effect genes, which are often functionally related and can be enriched within gene ontology (GO) pathways. However, optimizing marker subsets associated with these pathways to enhance GP performance remains challenging. In this study, we propose an improved GS framework called binGO-GS by integrating GO-based biological priors with a novel bin-based combinatorial SNP subset selection strategy. We evaluated the performance of binGO-GS on nine quantitative traits from two A. thaliana datasets, comprising nearly 1,000 samples and over 1.8 million SNPs. Compared with using either the full marker set or randomly selected markers with Genomic BLUP (GBLUP), binGO-GS achieved statistically significant improvements in prediction accuracy across all traits. Similar improvements were observed across six additional regression models when applying binGO-GS instead of the full marker set. Furthermore, the selected markers for identical or similar morphological traits exhibited consistent patterns in quantity and genomic distribution, supporting the polygenic model of complex quantitative traits driven by minor-effect genes. Taken together, binGO-GS offers a powerful and interpretable approach to enhance GS performance, providing a methodological reference for accelerating plant breeding and germplasm innovation.https://www.frontiersin.org/articles/10.3389/fbinf.2025.1607119/fullgenomic selection/predictionSNPsubset selectiongene ontologybiological priorsArabidopsis thaliana |
| spellingShingle | Qingfang Ba Heng Zhou Zheming Yuan Zhijun Dai Enhancing genomic prediction in Arabidopsis thaliana with optimized SNP subset by leveraging gene ontology priors and bin-based combinatorial optimization Frontiers in Bioinformatics genomic selection/prediction SNP subset selection gene ontology biological priors Arabidopsis thaliana |
| title | Enhancing genomic prediction in Arabidopsis thaliana with optimized SNP subset by leveraging gene ontology priors and bin-based combinatorial optimization |
| title_full | Enhancing genomic prediction in Arabidopsis thaliana with optimized SNP subset by leveraging gene ontology priors and bin-based combinatorial optimization |
| title_fullStr | Enhancing genomic prediction in Arabidopsis thaliana with optimized SNP subset by leveraging gene ontology priors and bin-based combinatorial optimization |
| title_full_unstemmed | Enhancing genomic prediction in Arabidopsis thaliana with optimized SNP subset by leveraging gene ontology priors and bin-based combinatorial optimization |
| title_short | Enhancing genomic prediction in Arabidopsis thaliana with optimized SNP subset by leveraging gene ontology priors and bin-based combinatorial optimization |
| title_sort | enhancing genomic prediction in arabidopsis thaliana with optimized snp subset by leveraging gene ontology priors and bin based combinatorial optimization |
| topic | genomic selection/prediction SNP subset selection gene ontology biological priors Arabidopsis thaliana |
| url | https://www.frontiersin.org/articles/10.3389/fbinf.2025.1607119/full |
| work_keys_str_mv | AT qingfangba enhancinggenomicpredictioninarabidopsisthalianawithoptimizedsnpsubsetbyleveraginggeneontologypriorsandbinbasedcombinatorialoptimization AT hengzhou enhancinggenomicpredictioninarabidopsisthalianawithoptimizedsnpsubsetbyleveraginggeneontologypriorsandbinbasedcombinatorialoptimization AT zhemingyuan enhancinggenomicpredictioninarabidopsisthalianawithoptimizedsnpsubsetbyleveraginggeneontologypriorsandbinbasedcombinatorialoptimization AT zhijundai enhancinggenomicpredictioninarabidopsisthalianawithoptimizedsnpsubsetbyleveraginggeneontologypriorsandbinbasedcombinatorialoptimization |