Cranial ultrasonographic screening findings among healthy neonates and their association with neurodevelopmental outcomes
Background: To analyze the findings of cranial ultrasonographic screening in asymptomatic neonates and to assess the association between abnormal results and neurodevelopment. Methods: We retrospectively reviewed the cranial ultrasonographic screening results of healthy neonates born between 35 and...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-03-01
|
| Series: | Pediatrics and Neonatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957220301765 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850198423304667136 |
|---|---|
| author | Yi-Jie Lin Nan-Chang Chiu Hui-Ju Chen Jia-Yun Huang Che-Sheng Ho |
| author_facet | Yi-Jie Lin Nan-Chang Chiu Hui-Ju Chen Jia-Yun Huang Che-Sheng Ho |
| author_sort | Yi-Jie Lin |
| collection | DOAJ |
| description | Background: To analyze the findings of cranial ultrasonographic screening in asymptomatic neonates and to assess the association between abnormal results and neurodevelopment. Methods: We retrospectively reviewed the cranial ultrasonographic screening results of healthy neonates born between 35 and 42 weeks gestation at our hospital from October 2011 to October 2018. Results: In total, 11,681 neonates underwent cranial ultrasonographic screening during the study period, and 9666 (82.7%) had normal results. Of 2015 neonates with abnormal findings, 294 had more than two abnormalities. The most common minor findings were subependymal cysts (8.99%), choroid plexus cysts (2.43%), lenticulostriate vasculopathy (2.34%), frontal horn cysts (1.80%), and enlarged cisterna magna (1.04%). Then, 33 (0.28%) neonates had major abnormalities, including cerebral hemorrhage, periventricular heterotopia, focal cortical dysplasia, anomalies of the corpus callosum, and vascular malformation. Of 1334 neonates who underwent serial clinical evaluations, 76 (5.69%) had neurodevelopmental disorders, including developmental delay, attention-deficit/hyperactivity disorder, and autistic spectrum disorder. Conclusion: The incidence rate of intracranial anomalies in healthy neonates was 17.3%, and about 5.69% had neurodevelopmental disorders. Cranial ultrasonographic screening has its own value in helping early detection of intracranial anomalies in healthy neonates, some of which have prognostic implications. |
| format | Article |
| id | doaj-art-8da993f8efba44ad877d9d0696b7900e |
| institution | OA Journals |
| issn | 1875-9572 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-8da993f8efba44ad877d9d0696b7900e2025-08-20T02:12:53ZengElsevierPediatrics and Neonatology1875-95722021-03-0162215816410.1016/j.pedneo.2020.10.012Cranial ultrasonographic screening findings among healthy neonates and their association with neurodevelopmental outcomesYi-Jie Lin0Nan-Chang Chiu1Hui-Ju Chen2Jia-Yun Huang3Che-Sheng Ho4Division of Pediatric Neurology, MacKay Children's Hospital, Taipei, TaiwanDivision of Pediatric Neurology, MacKay Children's Hospital, Taipei, Taiwan; Department of Medicine, MacKay Medical College, New Taipei City, TaiwanDivision of Pediatric Neurology, MacKay Children's Hospital, Taipei, Taiwan; Department of Medicine, MacKay Medical College, New Taipei City, TaiwanDivision of Pediatric Neurology, MacKay Children's Hospital, Taipei, TaiwanDivision of Pediatric Neurology, MacKay Children's Hospital, Taipei, Taiwan; Department of Medicine, MacKay Medical College, New Taipei City, Taiwan; Corresponding author. Mackay Children's Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Taipei City 10449, Taiwan. Fax: +886 2 25433642.Background: To analyze the findings of cranial ultrasonographic screening in asymptomatic neonates and to assess the association between abnormal results and neurodevelopment. Methods: We retrospectively reviewed the cranial ultrasonographic screening results of healthy neonates born between 35 and 42 weeks gestation at our hospital from October 2011 to October 2018. Results: In total, 11,681 neonates underwent cranial ultrasonographic screening during the study period, and 9666 (82.7%) had normal results. Of 2015 neonates with abnormal findings, 294 had more than two abnormalities. The most common minor findings were subependymal cysts (8.99%), choroid plexus cysts (2.43%), lenticulostriate vasculopathy (2.34%), frontal horn cysts (1.80%), and enlarged cisterna magna (1.04%). Then, 33 (0.28%) neonates had major abnormalities, including cerebral hemorrhage, periventricular heterotopia, focal cortical dysplasia, anomalies of the corpus callosum, and vascular malformation. Of 1334 neonates who underwent serial clinical evaluations, 76 (5.69%) had neurodevelopmental disorders, including developmental delay, attention-deficit/hyperactivity disorder, and autistic spectrum disorder. Conclusion: The incidence rate of intracranial anomalies in healthy neonates was 17.3%, and about 5.69% had neurodevelopmental disorders. Cranial ultrasonographic screening has its own value in helping early detection of intracranial anomalies in healthy neonates, some of which have prognostic implications.http://www.sciencedirect.com/science/article/pii/S1875957220301765Cranial ultrasonographic screeningEarly diagnosisFrontal horn cystsNeurodevelopmentSubependymal cysts |
| spellingShingle | Yi-Jie Lin Nan-Chang Chiu Hui-Ju Chen Jia-Yun Huang Che-Sheng Ho Cranial ultrasonographic screening findings among healthy neonates and their association with neurodevelopmental outcomes Pediatrics and Neonatology Cranial ultrasonographic screening Early diagnosis Frontal horn cysts Neurodevelopment Subependymal cysts |
| title | Cranial ultrasonographic screening findings among healthy neonates and their association with neurodevelopmental outcomes |
| title_full | Cranial ultrasonographic screening findings among healthy neonates and their association with neurodevelopmental outcomes |
| title_fullStr | Cranial ultrasonographic screening findings among healthy neonates and their association with neurodevelopmental outcomes |
| title_full_unstemmed | Cranial ultrasonographic screening findings among healthy neonates and their association with neurodevelopmental outcomes |
| title_short | Cranial ultrasonographic screening findings among healthy neonates and their association with neurodevelopmental outcomes |
| title_sort | cranial ultrasonographic screening findings among healthy neonates and their association with neurodevelopmental outcomes |
| topic | Cranial ultrasonographic screening Early diagnosis Frontal horn cysts Neurodevelopment Subependymal cysts |
| url | http://www.sciencedirect.com/science/article/pii/S1875957220301765 |
| work_keys_str_mv | AT yijielin cranialultrasonographicscreeningfindingsamonghealthyneonatesandtheirassociationwithneurodevelopmentaloutcomes AT nanchangchiu cranialultrasonographicscreeningfindingsamonghealthyneonatesandtheirassociationwithneurodevelopmentaloutcomes AT huijuchen cranialultrasonographicscreeningfindingsamonghealthyneonatesandtheirassociationwithneurodevelopmentaloutcomes AT jiayunhuang cranialultrasonographicscreeningfindingsamonghealthyneonatesandtheirassociationwithneurodevelopmentaloutcomes AT cheshengho cranialultrasonographicscreeningfindingsamonghealthyneonatesandtheirassociationwithneurodevelopmentaloutcomes |