HIV-1 neutralization profile and plant-based recombinant expression of actinohivin, an Env glycan-specific lectin devoid of T-cell mitogenic activity.

HIV-1 neutralization profile and plant-based recombinant expression of actinohivin, an Env glycan-specific lectin devoid of T-cell mitogenic activity.

The development of a topical microbicide blocking the sexual transmission of HIV-1 is urgently needed to control the global HIV/AIDS pandemic. The actinomycete-derived lectin actinohivin (AH) is highly specific to a cluster of high-mannose-type glycans uniquely found on the viral envelope (Env). Her...

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Main Authors: Nobuyuki Matoba, Adam S Husk, Brian W Barnett, Michelle M Pickel, Charles J Arntzen, David C Montefiori, Atsushi Takahashi, Kazunobu Tanno, Satoshi Omura, Huyen Cao, Jason P Mooney, Carl V Hanson, Haruo Tanaka
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011143&type=printable
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