Efficacy and Safety of Argon Laser Peripheral Iridoplasty and Systemic Medical Therapy in Asian Patients with Acute Primary Angle Closure: A Meta-Analysis of Randomized Controlled Trials

Purpose. The purpose of this meta-analysis was to assess the percent reduction in the intraocular pressure (IOP) after argon laser peripheral iridoplasty (ALPI) and systemic medical therapy in patients with acute primary angle closure (APAC). Methods. We searched a number of electronic databases, in...

Full description

Saved in:
Bibliographic Details
Main Authors: Wenting Cai, Qiyang Lou, Jiaqi Fan, Donghui Yu, Tianyi Shen, Jing Yu
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Journal of Ophthalmology
Online Access:http://dx.doi.org/10.1155/2019/7697416
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832548410168705024
author Wenting Cai
Qiyang Lou
Jiaqi Fan
Donghui Yu
Tianyi Shen
Jing Yu
author_facet Wenting Cai
Qiyang Lou
Jiaqi Fan
Donghui Yu
Tianyi Shen
Jing Yu
author_sort Wenting Cai
collection DOAJ
description Purpose. The purpose of this meta-analysis was to assess the percent reduction in the intraocular pressure (IOP) after argon laser peripheral iridoplasty (ALPI) and systemic medical therapy in patients with acute primary angle closure (APAC). Methods. We searched a number of electronic databases, including MEDLINE, EMBASE, PubMed, and Cochrane Library. We searched the electronic databases from the inception of the databases to August 2018. The primary outcomes included the IOP reduction (IOPR), percent reduction in IOP (IOPR%) from baseline to the endpoint and peripheral anterior synechiae (PAS). The secondary outcomes included the cup-to-disc ratio (CDR), mean endothelial count, and percent of patients requiring topical glaucoma medication. Summary weighted mean difference (WMD), odds ratio (OR), and 95% confidence intervals (CIs) were calculated. Results. Four eligible studies including 183 eyes (92 in the ALPI group and 91 in the medical therapy group) were identified. When comparing ALPI to medical therapy, the WMDs of the IOPR% were 30.03 (95% CI: 21.33 to 38.72, p<0.00001) at 15 minutes, 27.39 (95% CI: 18.89 to 35.89, p<0.00001) at 30 minutes, 18.15 (95% CI: 10.63 to 25.68, p<0.00001) at 1 hour, and 12.91 (95% CI: 4.50 to 21.32, p=0.003) at 2 hours. There was no statistically significant difference between the two groups at 24 hours and at more than 6 months after therapy. Meanwhile, no significant difference was observed in the degree of PAS, CDR, mean endothelial count, and percent of patients requiring topical glaucoma medication after treatment between the two groups. Conclusions. Both ALPI and systemic medications were effective with regard to decreasing the IOP. ALPI was more effective in lowering the IOP within the first two hours. Therefore, ALPI may be a better choice for rapidly lowering the IOP in patients with APAC within a short period.
format Article
id doaj-art-8da4252bde044b188849c5b54ff40a4f
institution Kabale University
issn 2090-004X
2090-0058
language English
publishDate 2019-01-01
publisher Wiley
record_format Article
series Journal of Ophthalmology
spelling doaj-art-8da4252bde044b188849c5b54ff40a4f2025-02-03T06:14:10ZengWileyJournal of Ophthalmology2090-004X2090-00582019-01-01201910.1155/2019/76974167697416Efficacy and Safety of Argon Laser Peripheral Iridoplasty and Systemic Medical Therapy in Asian Patients with Acute Primary Angle Closure: A Meta-Analysis of Randomized Controlled TrialsWenting Cai0Qiyang Lou1Jiaqi Fan2Donghui Yu3Tianyi Shen4Jing Yu5Department of Ophthalmology, Ninghai First Hospital, Ninghai, Zhejiang, ChinaDepartment of Ophthalmology, Ninghai First Hospital, Ninghai, Zhejiang, ChinaDepartment of Ophthalmology, Ninghai First Hospital, Ninghai, Zhejiang, ChinaDepartment of Ophthalmology, Ninghai First Hospital, Ninghai, Zhejiang, ChinaDepartment of Ophthalmology, Ninghai First Hospital, Ninghai, Zhejiang, ChinaDepartment of Ophthalmology, Ninghai First Hospital, Ninghai, Zhejiang, ChinaPurpose. The purpose of this meta-analysis was to assess the percent reduction in the intraocular pressure (IOP) after argon laser peripheral iridoplasty (ALPI) and systemic medical therapy in patients with acute primary angle closure (APAC). Methods. We searched a number of electronic databases, including MEDLINE, EMBASE, PubMed, and Cochrane Library. We searched the electronic databases from the inception of the databases to August 2018. The primary outcomes included the IOP reduction (IOPR), percent reduction in IOP (IOPR%) from baseline to the endpoint and peripheral anterior synechiae (PAS). The secondary outcomes included the cup-to-disc ratio (CDR), mean endothelial count, and percent of patients requiring topical glaucoma medication. Summary weighted mean difference (WMD), odds ratio (OR), and 95% confidence intervals (CIs) were calculated. Results. Four eligible studies including 183 eyes (92 in the ALPI group and 91 in the medical therapy group) were identified. When comparing ALPI to medical therapy, the WMDs of the IOPR% were 30.03 (95% CI: 21.33 to 38.72, p<0.00001) at 15 minutes, 27.39 (95% CI: 18.89 to 35.89, p<0.00001) at 30 minutes, 18.15 (95% CI: 10.63 to 25.68, p<0.00001) at 1 hour, and 12.91 (95% CI: 4.50 to 21.32, p=0.003) at 2 hours. There was no statistically significant difference between the two groups at 24 hours and at more than 6 months after therapy. Meanwhile, no significant difference was observed in the degree of PAS, CDR, mean endothelial count, and percent of patients requiring topical glaucoma medication after treatment between the two groups. Conclusions. Both ALPI and systemic medications were effective with regard to decreasing the IOP. ALPI was more effective in lowering the IOP within the first two hours. Therefore, ALPI may be a better choice for rapidly lowering the IOP in patients with APAC within a short period.http://dx.doi.org/10.1155/2019/7697416
spellingShingle Wenting Cai
Qiyang Lou
Jiaqi Fan
Donghui Yu
Tianyi Shen
Jing Yu
Efficacy and Safety of Argon Laser Peripheral Iridoplasty and Systemic Medical Therapy in Asian Patients with Acute Primary Angle Closure: A Meta-Analysis of Randomized Controlled Trials
Journal of Ophthalmology
title Efficacy and Safety of Argon Laser Peripheral Iridoplasty and Systemic Medical Therapy in Asian Patients with Acute Primary Angle Closure: A Meta-Analysis of Randomized Controlled Trials
title_full Efficacy and Safety of Argon Laser Peripheral Iridoplasty and Systemic Medical Therapy in Asian Patients with Acute Primary Angle Closure: A Meta-Analysis of Randomized Controlled Trials
title_fullStr Efficacy and Safety of Argon Laser Peripheral Iridoplasty and Systemic Medical Therapy in Asian Patients with Acute Primary Angle Closure: A Meta-Analysis of Randomized Controlled Trials
title_full_unstemmed Efficacy and Safety of Argon Laser Peripheral Iridoplasty and Systemic Medical Therapy in Asian Patients with Acute Primary Angle Closure: A Meta-Analysis of Randomized Controlled Trials
title_short Efficacy and Safety of Argon Laser Peripheral Iridoplasty and Systemic Medical Therapy in Asian Patients with Acute Primary Angle Closure: A Meta-Analysis of Randomized Controlled Trials
title_sort efficacy and safety of argon laser peripheral iridoplasty and systemic medical therapy in asian patients with acute primary angle closure a meta analysis of randomized controlled trials
url http://dx.doi.org/10.1155/2019/7697416
work_keys_str_mv AT wentingcai efficacyandsafetyofargonlaserperipheraliridoplastyandsystemicmedicaltherapyinasianpatientswithacuteprimaryangleclosureametaanalysisofrandomizedcontrolledtrials
AT qiyanglou efficacyandsafetyofargonlaserperipheraliridoplastyandsystemicmedicaltherapyinasianpatientswithacuteprimaryangleclosureametaanalysisofrandomizedcontrolledtrials
AT jiaqifan efficacyandsafetyofargonlaserperipheraliridoplastyandsystemicmedicaltherapyinasianpatientswithacuteprimaryangleclosureametaanalysisofrandomizedcontrolledtrials
AT donghuiyu efficacyandsafetyofargonlaserperipheraliridoplastyandsystemicmedicaltherapyinasianpatientswithacuteprimaryangleclosureametaanalysisofrandomizedcontrolledtrials
AT tianyishen efficacyandsafetyofargonlaserperipheraliridoplastyandsystemicmedicaltherapyinasianpatientswithacuteprimaryangleclosureametaanalysisofrandomizedcontrolledtrials
AT jingyu efficacyandsafetyofargonlaserperipheraliridoplastyandsystemicmedicaltherapyinasianpatientswithacuteprimaryangleclosureametaanalysisofrandomizedcontrolledtrials