The role of serum amyloid A as an inflammatory biomarker in patients with chronic inflammatory conditions
Aim: This study aimed to evaluate the diagnostic value of serum amyloid A (SAA) by comparing it with conventional acute phase markers (APMs), such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and fibrinogen, in patients experiencing pain related to chronic inflammatory and gal...
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| Format: | Article |
| Language: | English |
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Izzet Baysal Training and Research Hospital
2025-07-01
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| Series: | Northwestern Medical Journal |
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| Online Access: | https://nwmedj.org/article/view/144 |
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| author | Ali Osman Avcı |
| author_facet | Ali Osman Avcı |
| author_sort | Ali Osman Avcı |
| collection | DOAJ |
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Aim: This study aimed to evaluate the diagnostic value of serum amyloid A (SAA) by comparing it with conventional acute phase markers (APMs), such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and fibrinogen, in patients experiencing pain related to chronic inflammatory and gallbladder diseases.
Materials and Methods: We retrospectively examined data retrieved from the medical records of 601 patients diagnosed with chronic inflammatory disease, gallbladder stones who underwent cholecystectomy between January 2020 and June 2023. We compared serum levels of ESR, SAA, CRP, and fibrinogen during episodes of pain.
Results: The study population consisted of 601 patients, of whom 401 (66.72%) were female and 200 (33.28%) were male. The mean age was 48.74±17.20 years for females and 46.62±17.52 years for males. Serum SAA, CRP, ESR, and fibrinogen levels showed a statistically significant positive correlation. The most significant correlation was between SAA and CRP. However, there was no rise in CRP or other acute phase markers (APMs), even though SAA rose in about one-fourth of the patients (24.7%).
Conclusion: Monitoring chronic inflammatory diseases with SAA is thought to be useful for detecting subclinical inflammation and underlying chronic inflammatory diseases. It may also prevent the development of amyloidosis and therefore morbidity and mortality.
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| format | Article |
| id | doaj-art-8da335d9a9174a2aa2519cb0a670b320 |
| institution | Kabale University |
| issn | 2979-9538 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Izzet Baysal Training and Research Hospital |
| record_format | Article |
| series | Northwestern Medical Journal |
| spelling | doaj-art-8da335d9a9174a2aa2519cb0a670b3202025-08-20T03:38:59ZengIzzet Baysal Training and Research HospitalNorthwestern Medical Journal2979-95382025-07-015310.54307/2025.NWMJ.144The role of serum amyloid A as an inflammatory biomarker in patients with chronic inflammatory conditionsAli Osman Avcı0https://orcid.org/0000-0002-5849-5988Department of Internal Medicine, Sincan Application and Research Center, Lokman Hekim University Ankara Hospital, Ankara, Türkiye Aim: This study aimed to evaluate the diagnostic value of serum amyloid A (SAA) by comparing it with conventional acute phase markers (APMs), such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and fibrinogen, in patients experiencing pain related to chronic inflammatory and gallbladder diseases. Materials and Methods: We retrospectively examined data retrieved from the medical records of 601 patients diagnosed with chronic inflammatory disease, gallbladder stones who underwent cholecystectomy between January 2020 and June 2023. We compared serum levels of ESR, SAA, CRP, and fibrinogen during episodes of pain. Results: The study population consisted of 601 patients, of whom 401 (66.72%) were female and 200 (33.28%) were male. The mean age was 48.74±17.20 years for females and 46.62±17.52 years for males. Serum SAA, CRP, ESR, and fibrinogen levels showed a statistically significant positive correlation. The most significant correlation was between SAA and CRP. However, there was no rise in CRP or other acute phase markers (APMs), even though SAA rose in about one-fourth of the patients (24.7%). Conclusion: Monitoring chronic inflammatory diseases with SAA is thought to be useful for detecting subclinical inflammation and underlying chronic inflammatory diseases. It may also prevent the development of amyloidosis and therefore morbidity and mortality. https://nwmedj.org/article/view/144Chronic inflammatory diseasesserum amyloid AC-reactive proteinerythrocyte sedimentation ratefibrinogen |
| spellingShingle | Ali Osman Avcı The role of serum amyloid A as an inflammatory biomarker in patients with chronic inflammatory conditions Northwestern Medical Journal Chronic inflammatory diseases serum amyloid A C-reactive protein erythrocyte sedimentation rate fibrinogen |
| title | The role of serum amyloid A as an inflammatory biomarker in patients with chronic inflammatory conditions |
| title_full | The role of serum amyloid A as an inflammatory biomarker in patients with chronic inflammatory conditions |
| title_fullStr | The role of serum amyloid A as an inflammatory biomarker in patients with chronic inflammatory conditions |
| title_full_unstemmed | The role of serum amyloid A as an inflammatory biomarker in patients with chronic inflammatory conditions |
| title_short | The role of serum amyloid A as an inflammatory biomarker in patients with chronic inflammatory conditions |
| title_sort | role of serum amyloid a as an inflammatory biomarker in patients with chronic inflammatory conditions |
| topic | Chronic inflammatory diseases serum amyloid A C-reactive protein erythrocyte sedimentation rate fibrinogen |
| url | https://nwmedj.org/article/view/144 |
| work_keys_str_mv | AT aliosmanavcı theroleofserumamyloidaasaninflammatorybiomarkerinpatientswithchronicinflammatoryconditions AT aliosmanavcı roleofserumamyloidaasaninflammatorybiomarkerinpatientswithchronicinflammatoryconditions |