Protective Effects Of Tecomella Undulata Stem Bark Extract On Isoniazid Induced Hepatotoxicity: Based On Liver Enzymes And Histopathology In Rat Model
Objective: To evaluate the hepatoprotective effects of Tecomellaundulata stem bark extract on isoniazid induced hepatic damage based on liver enzymes and Liver function test in rat models. Study design and Setting: An experimental study conducted at Department of Pharmacology at Al-Tibri Medical Co...
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| Format: | Article |
| Language: | English |
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Bahria Univerisy Health Sciences, Campus Karachi
2021-03-01
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| Series: | Journal of Bahria University Medical and Dental College |
| Online Access: | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/420 |
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| author | Zubaida Umar Zehri Shabih Zehra Abdul Lateef Mahesar M. Anwar Syed Ijaz Hussain Zaidi M. Ashraf |
| author_facet | Zubaida Umar Zehri Shabih Zehra Abdul Lateef Mahesar M. Anwar Syed Ijaz Hussain Zaidi M. Ashraf |
| author_sort | Zubaida Umar Zehri |
| collection | DOAJ |
| description |
Objective: To evaluate the hepatoprotective effects of Tecomellaundulata stem bark extract on isoniazid induced hepatic
damage based on liver enzymes and Liver function test in rat models.
Study design and Setting: An experimental study conducted at Department of Pharmacology at Al-Tibri Medical College
and Hospital, Isra University Karachi Campus and Dow University of Health Sciences, Karachi.
Methodology: Total twenty-four rats were studied. The albino rats that were male, healthy, and weighing 200-250grams
were included in this study. Rats were divided into four groups, each group having six rats and treated once daily orally
for 30 days. Group A was control group and treated with normal animal diet and water; Group B was Isoniazid treated
group and induced by oral administration of Isoniazid (INH) 50mg/kg. Group C was treated with Isoniazid 50mg/kg and
Tecomellaundulata bark extract with low dose of 200mg/kg . Group D was treated with Isoniazid 50mg/kg and
Tecomellaundulata bark extract with high dose of 400mg/kg . All the animals were weighed before commencement of the
study. Liver enzymes were noted after the end of experiment. P value of <0.05 was taken as significant.
Results: While comparing the mean values of AST,ALT, ALP and GGT in all four groups group; the statistical significant
difference (p<0.001) was found. The mean levels in of total Bilirubin in group A was 0.69 ±0.01, group B 1.04 ±0.04, in
group C was 1.15 ±0.39, and in group D was 1.04 ±0.44 with the significant difference (p=0.004).
Conclusion: Tecomellaundulata has a protective effect on isoniazid induced toxicity on liver as evidenced by liver function
test on rat models.
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| format | Article |
| id | doaj-art-8d9fc8e9cf1a4e9298cd8613dce0fcb1 |
| institution | DOAJ |
| issn | 2220-7562 2617-9482 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Bahria Univerisy Health Sciences, Campus Karachi |
| record_format | Article |
| series | Journal of Bahria University Medical and Dental College |
| spelling | doaj-art-8d9fc8e9cf1a4e9298cd8613dce0fcb12025-08-20T03:10:54ZengBahria Univerisy Health Sciences, Campus KarachiJournal of Bahria University Medical and Dental College2220-75622617-94822021-03-0110110.51985/JBUMDC2019124Protective Effects Of Tecomella Undulata Stem Bark Extract On Isoniazid Induced Hepatotoxicity: Based On Liver Enzymes And Histopathology In Rat ModelZubaida Umar ZehriShabih ZehraAbdul Lateef MahesarM. AnwarSyed Ijaz Hussain ZaidiM. Ashraf Objective: To evaluate the hepatoprotective effects of Tecomellaundulata stem bark extract on isoniazid induced hepatic damage based on liver enzymes and Liver function test in rat models. Study design and Setting: An experimental study conducted at Department of Pharmacology at Al-Tibri Medical College and Hospital, Isra University Karachi Campus and Dow University of Health Sciences, Karachi. Methodology: Total twenty-four rats were studied. The albino rats that were male, healthy, and weighing 200-250grams were included in this study. Rats were divided into four groups, each group having six rats and treated once daily orally for 30 days. Group A was control group and treated with normal animal diet and water; Group B was Isoniazid treated group and induced by oral administration of Isoniazid (INH) 50mg/kg. Group C was treated with Isoniazid 50mg/kg and Tecomellaundulata bark extract with low dose of 200mg/kg . Group D was treated with Isoniazid 50mg/kg and Tecomellaundulata bark extract with high dose of 400mg/kg . All the animals were weighed before commencement of the study. Liver enzymes were noted after the end of experiment. P value of <0.05 was taken as significant. Results: While comparing the mean values of AST,ALT, ALP and GGT in all four groups group; the statistical significant difference (p<0.001) was found. The mean levels in of total Bilirubin in group A was 0.69 ±0.01, group B 1.04 ±0.04, in group C was 1.15 ±0.39, and in group D was 1.04 ±0.44 with the significant difference (p=0.004). Conclusion: Tecomellaundulata has a protective effect on isoniazid induced toxicity on liver as evidenced by liver function test on rat models. https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/420 |
| spellingShingle | Zubaida Umar Zehri Shabih Zehra Abdul Lateef Mahesar M. Anwar Syed Ijaz Hussain Zaidi M. Ashraf Protective Effects Of Tecomella Undulata Stem Bark Extract On Isoniazid Induced Hepatotoxicity: Based On Liver Enzymes And Histopathology In Rat Model Journal of Bahria University Medical and Dental College |
| title | Protective Effects Of Tecomella Undulata Stem Bark Extract On Isoniazid Induced Hepatotoxicity: Based On Liver Enzymes And Histopathology In Rat Model |
| title_full | Protective Effects Of Tecomella Undulata Stem Bark Extract On Isoniazid Induced Hepatotoxicity: Based On Liver Enzymes And Histopathology In Rat Model |
| title_fullStr | Protective Effects Of Tecomella Undulata Stem Bark Extract On Isoniazid Induced Hepatotoxicity: Based On Liver Enzymes And Histopathology In Rat Model |
| title_full_unstemmed | Protective Effects Of Tecomella Undulata Stem Bark Extract On Isoniazid Induced Hepatotoxicity: Based On Liver Enzymes And Histopathology In Rat Model |
| title_short | Protective Effects Of Tecomella Undulata Stem Bark Extract On Isoniazid Induced Hepatotoxicity: Based On Liver Enzymes And Histopathology In Rat Model |
| title_sort | protective effects of tecomella undulata stem bark extract on isoniazid induced hepatotoxicity based on liver enzymes and histopathology in rat model |
| url | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/420 |
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