A Single Mass Forming Colonic Primary Mantle Cell Lymphoma
Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin’s lymphoma (NHL) comprising around 7% of adult NHL. It is characterized by a chromosomal translocation t(11:14) and overexpression of Cyclin D1. The incidence of secondary gastrointestinal tract involvement in MCL ranges from 10 to 28% in variou...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/2561507 |
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| author | Fady Daniel Hazem I. Assi Walid Karaoui Jean El Cheikh Sami Bannoura Samer Nassif |
| author_facet | Fady Daniel Hazem I. Assi Walid Karaoui Jean El Cheikh Sami Bannoura Samer Nassif |
| author_sort | Fady Daniel |
| collection | DOAJ |
| description | Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin’s lymphoma (NHL) comprising around 7% of adult NHL. It is characterized by a chromosomal translocation t(11:14) and overexpression of Cyclin D1. The incidence of secondary gastrointestinal tract involvement in MCL ranges from 10 to 28% in various series. However primary gastrointestinal MCL is very rare, accounting for only 1 to 4% of primary gastrointestinal lymphomas. The most common endoscopic feature of primary intestinal MCL is multiple lymphomatous polyposis. In rare cases it presents as protruded lesions or superficial lesions. Single colonic mass presentation is an extremely infrequent presentation. MCL has an aggressive course with quick progression, and most cases are discovered in the advanced stages. Colonic biopsies with histologic examination and specific immunohistochemical staining are the gold standard for a proper diagnosis. We report a case of a single mass forming mantle cell lymphoma of the ascending colon in a 57-year-old female patient with unusual colonoscopic and radiologic features and describe the therapy the patient received, thereby adding to the spectrum of clinical presentations of this aggressive lymphoproliferative disorder. |
| format | Article |
| id | doaj-art-8d9f9ad95805498daa46da9fe4f7dd20 |
| institution | OA Journals |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-8d9f9ad95805498daa46da9fe4f7dd202025-08-20T02:09:38ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362016-01-01201610.1155/2016/25615072561507A Single Mass Forming Colonic Primary Mantle Cell LymphomaFady Daniel0Hazem I. Assi1Walid Karaoui2Jean El Cheikh3Sami Bannoura4Samer Nassif5Division of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, Beirut 110-72020, LebanonDivision of Hematology & Oncology, Department of Internal Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, Beirut 110-72020, LebanonDivision of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, Beirut 110-72020, LebanonDivision of Hematology & Oncology, Department of Internal Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, Beirut 110-72020, LebanonPathology and Laboratory Medicine Department, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, Beirut 110-72020, LebanonPathology and Laboratory Medicine Department, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, Beirut 110-72020, LebanonMantle cell lymphoma (MCL) is a subtype of non-Hodgkin’s lymphoma (NHL) comprising around 7% of adult NHL. It is characterized by a chromosomal translocation t(11:14) and overexpression of Cyclin D1. The incidence of secondary gastrointestinal tract involvement in MCL ranges from 10 to 28% in various series. However primary gastrointestinal MCL is very rare, accounting for only 1 to 4% of primary gastrointestinal lymphomas. The most common endoscopic feature of primary intestinal MCL is multiple lymphomatous polyposis. In rare cases it presents as protruded lesions or superficial lesions. Single colonic mass presentation is an extremely infrequent presentation. MCL has an aggressive course with quick progression, and most cases are discovered in the advanced stages. Colonic biopsies with histologic examination and specific immunohistochemical staining are the gold standard for a proper diagnosis. We report a case of a single mass forming mantle cell lymphoma of the ascending colon in a 57-year-old female patient with unusual colonoscopic and radiologic features and describe the therapy the patient received, thereby adding to the spectrum of clinical presentations of this aggressive lymphoproliferative disorder.http://dx.doi.org/10.1155/2016/2561507 |
| spellingShingle | Fady Daniel Hazem I. Assi Walid Karaoui Jean El Cheikh Sami Bannoura Samer Nassif A Single Mass Forming Colonic Primary Mantle Cell Lymphoma Case Reports in Gastrointestinal Medicine |
| title | A Single Mass Forming Colonic Primary Mantle Cell Lymphoma |
| title_full | A Single Mass Forming Colonic Primary Mantle Cell Lymphoma |
| title_fullStr | A Single Mass Forming Colonic Primary Mantle Cell Lymphoma |
| title_full_unstemmed | A Single Mass Forming Colonic Primary Mantle Cell Lymphoma |
| title_short | A Single Mass Forming Colonic Primary Mantle Cell Lymphoma |
| title_sort | single mass forming colonic primary mantle cell lymphoma |
| url | http://dx.doi.org/10.1155/2016/2561507 |
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