<i>Moesziomyces aphidis</i> Bloodstream Infection in Oncologic Patient: First Report in Poland
<i>Moesziomyces</i> spp. (<i>Pseudozyma</i>) is a genus recognized as a new opportunistic human pathogen, causing systemic infections including premature neonates and adult patients. These fungi’s natural resistance to caspofungin enables them to spread through vascular cathe...
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2025-01-01
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| author | Beata Sulik-Tyszka Jolanta Małyszko Agnieszka Pęczuła Sylwia Jarzynka |
| author_facet | Beata Sulik-Tyszka Jolanta Małyszko Agnieszka Pęczuła Sylwia Jarzynka |
| author_sort | Beata Sulik-Tyszka |
| collection | DOAJ |
| description | <i>Moesziomyces</i> spp. (<i>Pseudozyma</i>) is a genus recognized as a new opportunistic human pathogen, causing systemic infections including premature neonates and adult patients. These fungi’s natural resistance to caspofungin enables them to spread through vascular catheter colonization, making them a new etiological agent associated with fungal bloodstream infections (FBIs) and a significant contributor to high mortality rates. In this report, we present a case of fungemia caused by <i>Moesziomyces aphidis</i> species in a patient with medical history that revealed pancreatic cancer infiltrating the duodenum and bile ducts. During hospitalization, the <i>M. aphidis</i> was cultured twice from peripheral blood samples on Sabouraud agar. The strain was sensitive to amphotericin B and voriconazole. In vitro susceptibility testing revealed resistance to fluconazole, caspofungin, anidulafungin, and micafungin. Antifungal therapy with voriconazole resulted in the resolution of clinical symptoms associated with fungal infection. Related to <i>M. aphidis</i> fungemia, we reviewed a total of three cases in Europe published in the PubMed database between 2003 and 2024. To the best of our knowledge, this is the first case of <i>M. aphidis</i> FBI in Poland and the fourth case in an adult patient in Europe. |
| format | Article |
| id | doaj-art-8d9e231678c74dc5a16c0c0cfda1f7cc |
| institution | DOAJ |
| issn | 2309-608X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Journal of Fungi |
| spelling | doaj-art-8d9e231678c74dc5a16c0c0cfda1f7cc2025-08-20T02:44:46ZengMDPI AGJournal of Fungi2309-608X2025-01-011129510.3390/jof11020095<i>Moesziomyces aphidis</i> Bloodstream Infection in Oncologic Patient: First Report in PolandBeata Sulik-Tyszka0Jolanta Małyszko1Agnieszka Pęczuła2Sylwia Jarzynka3Department of Microbiology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, PolandDepartment of Nephrology, Dialysis and Internal Medicine, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Gastroenterology and Internal Medicine, Medical University of Warsaw, 02-091 Warsaw, PolandLaboratory of Microbiology, University Center of Laboratory Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland<i>Moesziomyces</i> spp. (<i>Pseudozyma</i>) is a genus recognized as a new opportunistic human pathogen, causing systemic infections including premature neonates and adult patients. These fungi’s natural resistance to caspofungin enables them to spread through vascular catheter colonization, making them a new etiological agent associated with fungal bloodstream infections (FBIs) and a significant contributor to high mortality rates. In this report, we present a case of fungemia caused by <i>Moesziomyces aphidis</i> species in a patient with medical history that revealed pancreatic cancer infiltrating the duodenum and bile ducts. During hospitalization, the <i>M. aphidis</i> was cultured twice from peripheral blood samples on Sabouraud agar. The strain was sensitive to amphotericin B and voriconazole. In vitro susceptibility testing revealed resistance to fluconazole, caspofungin, anidulafungin, and micafungin. Antifungal therapy with voriconazole resulted in the resolution of clinical symptoms associated with fungal infection. Related to <i>M. aphidis</i> fungemia, we reviewed a total of three cases in Europe published in the PubMed database between 2003 and 2024. To the best of our knowledge, this is the first case of <i>M. aphidis</i> FBI in Poland and the fourth case in an adult patient in Europe.https://www.mdpi.com/2309-608X/11/2/95<i>Moesziomyces</i> (<i>Pseudozyma</i>) spp.fungal bloodstream infectionsrare yeastantifungal resistance |
| spellingShingle | Beata Sulik-Tyszka Jolanta Małyszko Agnieszka Pęczuła Sylwia Jarzynka <i>Moesziomyces aphidis</i> Bloodstream Infection in Oncologic Patient: First Report in Poland Journal of Fungi <i>Moesziomyces</i> (<i>Pseudozyma</i>) spp. fungal bloodstream infections rare yeast antifungal resistance |
| title | <i>Moesziomyces aphidis</i> Bloodstream Infection in Oncologic Patient: First Report in Poland |
| title_full | <i>Moesziomyces aphidis</i> Bloodstream Infection in Oncologic Patient: First Report in Poland |
| title_fullStr | <i>Moesziomyces aphidis</i> Bloodstream Infection in Oncologic Patient: First Report in Poland |
| title_full_unstemmed | <i>Moesziomyces aphidis</i> Bloodstream Infection in Oncologic Patient: First Report in Poland |
| title_short | <i>Moesziomyces aphidis</i> Bloodstream Infection in Oncologic Patient: First Report in Poland |
| title_sort | i moesziomyces aphidis i bloodstream infection in oncologic patient first report in poland |
| topic | <i>Moesziomyces</i> (<i>Pseudozyma</i>) spp. fungal bloodstream infections rare yeast antifungal resistance |
| url | https://www.mdpi.com/2309-608X/11/2/95 |
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