Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by Phytochemicals
The intestine plays an essential role in integrating immunity and nutrient digestion and absorption. Adjacent intestinal epithelia form tight junctions (TJs) that are essential to the function of the physical intestinal barrier, regulating the paracellular movement of various substances including io...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/2645465 |
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| _version_ | 1850211082148249600 |
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| author | Bonggi Lee Kyoung Mi Moon Choon Young Kim |
| author_facet | Bonggi Lee Kyoung Mi Moon Choon Young Kim |
| author_sort | Bonggi Lee |
| collection | DOAJ |
| description | The intestine plays an essential role in integrating immunity and nutrient digestion and absorption. Adjacent intestinal epithelia form tight junctions (TJs) that are essential to the function of the physical intestinal barrier, regulating the paracellular movement of various substances including ions, solutes, and water across the intestinal epithelium. Studies have shown that TJ dysfunction is highly associated with metabolic and inflammatory diseases. Thus, molecular and nutritional factors that improve TJ activity have gained attention in the pharmaceutical and medicinal fields. This review focuses on the association between TJ and diverse pathological conditions, as well as various molecular and nutritional interventions designed to boost TJ integrity. |
| format | Article |
| id | doaj-art-8d9dc2c452ae48a9860228efda13071f |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-8d9dc2c452ae48a9860228efda13071f2025-08-20T02:09:38ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/26454652645465Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by PhytochemicalsBonggi Lee0Kyoung Mi Moon1Choon Young Kim2Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine (KIOM), 70 Cheomdan-ro, Dong-gu, Daegu 41062, Republic of KoreaDepartment of Food Science and Nutrition, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 48513, Republic of KoreaDepartment of Food and Nutrition, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Republic of KoreaThe intestine plays an essential role in integrating immunity and nutrient digestion and absorption. Adjacent intestinal epithelia form tight junctions (TJs) that are essential to the function of the physical intestinal barrier, regulating the paracellular movement of various substances including ions, solutes, and water across the intestinal epithelium. Studies have shown that TJ dysfunction is highly associated with metabolic and inflammatory diseases. Thus, molecular and nutritional factors that improve TJ activity have gained attention in the pharmaceutical and medicinal fields. This review focuses on the association between TJ and diverse pathological conditions, as well as various molecular and nutritional interventions designed to boost TJ integrity.http://dx.doi.org/10.1155/2018/2645465 |
| spellingShingle | Bonggi Lee Kyoung Mi Moon Choon Young Kim Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by Phytochemicals Journal of Immunology Research |
| title | Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by Phytochemicals |
| title_full | Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by Phytochemicals |
| title_fullStr | Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by Phytochemicals |
| title_full_unstemmed | Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by Phytochemicals |
| title_short | Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by Phytochemicals |
| title_sort | tight junction in the intestinal epithelium its association with diseases and regulation by phytochemicals |
| url | http://dx.doi.org/10.1155/2018/2645465 |
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