FAPI-PET/CT guided radiotherapy for patients with esophageal cancer
Abstract Background Cancer associated fibroblasts have become a target of interest in different malignancies for positron emission tomography (PET) imaging, using positron emitter labelled fibroblast activation protein inhibitors (FAPI). New data underline the advanced imaging properties of FAPI-PET...
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BMC
2025-02-01
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| Series: | Radiation Oncology |
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| Online Access: | https://doi.org/10.1186/s13014-025-02606-x |
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| author | Kai Kröger Niklas Benedikt Pepper David Ventura Fabian M. Troschel Philipp Backhaus Kambiz Rahbar Bernhard Glasbrenner Matthias Brüwer Andreas Pascher Michael Schäfers Hans Theodor Eich Wolfgang Roll |
| author_facet | Kai Kröger Niklas Benedikt Pepper David Ventura Fabian M. Troschel Philipp Backhaus Kambiz Rahbar Bernhard Glasbrenner Matthias Brüwer Andreas Pascher Michael Schäfers Hans Theodor Eich Wolfgang Roll |
| author_sort | Kai Kröger |
| collection | DOAJ |
| description | Abstract Background Cancer associated fibroblasts have become a target of interest in different malignancies for positron emission tomography (PET) imaging, using positron emitter labelled fibroblast activation protein inhibitors (FAPI). New data underline the advanced imaging properties of FAPI-PET/CT for the staging of esophageal cancer compared to standard imaging. Potential benefits of FAPI-PET/CT in radiation therapy planning are the subject of this investigation. Methods Ten patients with newly diagnosed esophageal cancer treated with radiochemotherapy (RCT) were retrospectively analyzed. All patients underwent [68Ga]OncoFAP-PET/CT in treatment position to facilitate radiation treatment planning. Six patients received neoadjuvant RCT as part of a trimodal therapy and four patients underwent definitive RCT. In five cases, restaging after initial treatment was performed with FAPI-PET/CT. Results [68Ga]OncoFAP-PET/CT based imaging showed a high correlation with the endoscopic staging for initial imaging. In three cases, new sites of disease were unmasked, not visible in CT- and endosonographic staging. [68Ga]OncoFAP-PET/CT based RT delineation offered good definition of clinical target volumes, especially in retro-/paracardial areas and the gastroesophageal junction. Conclusion [68Ga]OncoFAP-PET/CT may aid and improve radiation treatment planning for patients with esophageal cancer. |
| format | Article |
| id | doaj-art-8d9d48e33e684cdd8b4695b3dd8d0781 |
| institution | DOAJ |
| issn | 1748-717X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj-art-8d9d48e33e684cdd8b4695b3dd8d07812025-08-20T02:54:36ZengBMCRadiation Oncology1748-717X2025-02-012011910.1186/s13014-025-02606-xFAPI-PET/CT guided radiotherapy for patients with esophageal cancerKai Kröger0Niklas Benedikt Pepper1David Ventura2Fabian M. Troschel3Philipp Backhaus4Kambiz Rahbar5Bernhard Glasbrenner6Matthias Brüwer7Andreas Pascher8Michael Schäfers9Hans Theodor Eich10Wolfgang Roll11Department of Radiation Oncology, University Hospital MuensterDepartment of Radiation Oncology, University Hospital MuensterDepartment of Nuclear Medicine, University Hospital MuensterDepartment of Radiation Oncology, University Hospital MuensterDepartment of Nuclear Medicine, University Hospital MuensterDepartment of Nuclear Medicine, University Hospital MuensterDepartment of Medicine B, Gastroenterology, St. Franziskus-Hospital MuensterDepartment of General and Visceral Surgery, Gastroenterology, St. Franziskus-Hospital MuensterDepartment of General, Visceral and Transplantation Surgery, University Hospital MuensterDepartment of Nuclear Medicine, University Hospital MuensterDepartment of Radiation Oncology, University Hospital MuensterDepartment of Nuclear Medicine, University Hospital MuensterAbstract Background Cancer associated fibroblasts have become a target of interest in different malignancies for positron emission tomography (PET) imaging, using positron emitter labelled fibroblast activation protein inhibitors (FAPI). New data underline the advanced imaging properties of FAPI-PET/CT for the staging of esophageal cancer compared to standard imaging. Potential benefits of FAPI-PET/CT in radiation therapy planning are the subject of this investigation. Methods Ten patients with newly diagnosed esophageal cancer treated with radiochemotherapy (RCT) were retrospectively analyzed. All patients underwent [68Ga]OncoFAP-PET/CT in treatment position to facilitate radiation treatment planning. Six patients received neoadjuvant RCT as part of a trimodal therapy and four patients underwent definitive RCT. In five cases, restaging after initial treatment was performed with FAPI-PET/CT. Results [68Ga]OncoFAP-PET/CT based imaging showed a high correlation with the endoscopic staging for initial imaging. In three cases, new sites of disease were unmasked, not visible in CT- and endosonographic staging. [68Ga]OncoFAP-PET/CT based RT delineation offered good definition of clinical target volumes, especially in retro-/paracardial areas and the gastroesophageal junction. Conclusion [68Ga]OncoFAP-PET/CT may aid and improve radiation treatment planning for patients with esophageal cancer.https://doi.org/10.1186/s13014-025-02606-xFAPIEsophageal cancerPETRadiotherapy |
| spellingShingle | Kai Kröger Niklas Benedikt Pepper David Ventura Fabian M. Troschel Philipp Backhaus Kambiz Rahbar Bernhard Glasbrenner Matthias Brüwer Andreas Pascher Michael Schäfers Hans Theodor Eich Wolfgang Roll FAPI-PET/CT guided radiotherapy for patients with esophageal cancer Radiation Oncology FAPI Esophageal cancer PET Radiotherapy |
| title | FAPI-PET/CT guided radiotherapy for patients with esophageal cancer |
| title_full | FAPI-PET/CT guided radiotherapy for patients with esophageal cancer |
| title_fullStr | FAPI-PET/CT guided radiotherapy for patients with esophageal cancer |
| title_full_unstemmed | FAPI-PET/CT guided radiotherapy for patients with esophageal cancer |
| title_short | FAPI-PET/CT guided radiotherapy for patients with esophageal cancer |
| title_sort | fapi pet ct guided radiotherapy for patients with esophageal cancer |
| topic | FAPI Esophageal cancer PET Radiotherapy |
| url | https://doi.org/10.1186/s13014-025-02606-x |
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