Targeting of the IL-33/Wnt axis restricts breast cancer stemness and metastasis

Targeting of the IL-33/Wnt axis restricts breast cancer stemness and metastasis

Abstract Interleukin-33 (IL-33) plays multifaceted roles in tumor progression, but its autocrine regulation of breast cancer stemness and metastasis via the Wnt pathway remains unclear. Here, we investigated the IL-33/ST2 axis in breast cancer using CRISPR/Cas9, single-cell RNA sequencing, and murin...

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Bibliographic Details
Main Authors: Guanglin Fan, Shuting Zuo, Zhen Wang, Siwei Zhang, Liping Liu, Haoge Luo, Yingdong Xie, Yan Zhang, Dong Li
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
IL-33
ST2 knockdown
Breast cancer stem cells
Wnt pathway
Immunotherapy
Online Access:https://doi.org/10.1038/s41598-025-03260-9
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