Cohort profile: Research on Obesity and Diabetes among African Migrants in Europe and Africa Prospective (RODAM-Pros) cohort study
Purpose The Research on Obesity and Diabetes among African Migrants (RODAM) prospective (RODAM-Pros) cohort study was established to identify key changes in environmental exposures and epigenetic modifications driving the high burden of cardiovascular disease (CVD) risk among sub-Saharan African mig...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/12/e067906.full |
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| author | Charles Agyemang Ellis Owusu-Dabo Erik Beune Karlijn Meeks Bert-Jan H van den Born Peter Henneman Sampson Twumasi-Ankrah Eva L van der Linden Daniel Antwi-Berko Samuel Nkansah Darko |
| author_facet | Charles Agyemang Ellis Owusu-Dabo Erik Beune Karlijn Meeks Bert-Jan H van den Born Peter Henneman Sampson Twumasi-Ankrah Eva L van der Linden Daniel Antwi-Berko Samuel Nkansah Darko |
| author_sort | Charles Agyemang |
| collection | DOAJ |
| description | Purpose The Research on Obesity and Diabetes among African Migrants (RODAM) prospective (RODAM-Pros) cohort study was established to identify key changes in environmental exposures and epigenetic modifications driving the high burden of cardiovascular disease (CVD) risk among sub-Saharan African migrants.Participants All the participants in the RODAM cross-sectional study that completed the baseline assessment (n=5114) were eligible for the follow-up of which 2165 participants (n=638 from rural-Ghana, n=608 from urban-Ghana, and n=919 Ghanaian migrants in Amsterdam, the Netherlands) were included in the RODAM-Pros cohort study. Additionally, we included a subsample of European-Dutch (n=2098) to enable a comparison to be made between Ghanaian migrants living in the Netherlands and the European-Dutch host population.Findings to date Follow-up data have been collected on demographics, socioeconomic status, medical history, psychosocial environment, lifestyle factors, nutrition, anthropometrics, blood pressure, fasting blood, urine and stool samples. Biochemical analyses included glucose metabolism, lipid profile, electrolytes and renal function, liver metabolism and inflammation. In a subsample, we assessed DNA methylation patterns using Infinium 850K DNA Methylation BeadChip. Baseline results indicated that migrants have higher prevalence of CVD risk factors than non-migrants. Epigenome-wide association studies suggest important differences in DNA methylation between migrants and non-migrants. The follow-up study will shed further light on key-specific environmental exposures and epigenetic modifications contributing to the high burden of CVD risk among sub-Saharan African migrants.Future plans Follow-up is planned at 5-year intervals, baseline completed in 2015 and first follow-up completed in 2021. |
| format | Article |
| id | doaj-art-8d9aa169db1748eeb4d42173ec473d28 |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-8d9aa169db1748eeb4d42173ec473d282025-08-20T02:57:08ZengBMJ Publishing GroupBMJ Open2044-60552022-12-01121210.1136/bmjopen-2022-067906Cohort profile: Research on Obesity and Diabetes among African Migrants in Europe and Africa Prospective (RODAM-Pros) cohort studyCharles Agyemang0Ellis Owusu-Dabo1Erik Beune2Karlijn Meeks3Bert-Jan H van den Born4Peter Henneman5Sampson Twumasi-Ankrah6Eva L van der Linden7Daniel Antwi-Berko8Samuel Nkansah Darko9Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA3 Department of Global and International Health, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaDepartment of Public and Occupational Health, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Public and Occupational Health, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands11Department of Clinical Genetics, Academic Medical Centre, Amsterdam, The NetherlandsDepartment of Statistics and Actuarial Science, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaDepartment of Public and Occupational Health, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Public and Occupational Health, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The NetherlandsSchool of Public Health, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, GhanaPurpose The Research on Obesity and Diabetes among African Migrants (RODAM) prospective (RODAM-Pros) cohort study was established to identify key changes in environmental exposures and epigenetic modifications driving the high burden of cardiovascular disease (CVD) risk among sub-Saharan African migrants.Participants All the participants in the RODAM cross-sectional study that completed the baseline assessment (n=5114) were eligible for the follow-up of which 2165 participants (n=638 from rural-Ghana, n=608 from urban-Ghana, and n=919 Ghanaian migrants in Amsterdam, the Netherlands) were included in the RODAM-Pros cohort study. Additionally, we included a subsample of European-Dutch (n=2098) to enable a comparison to be made between Ghanaian migrants living in the Netherlands and the European-Dutch host population.Findings to date Follow-up data have been collected on demographics, socioeconomic status, medical history, psychosocial environment, lifestyle factors, nutrition, anthropometrics, blood pressure, fasting blood, urine and stool samples. Biochemical analyses included glucose metabolism, lipid profile, electrolytes and renal function, liver metabolism and inflammation. In a subsample, we assessed DNA methylation patterns using Infinium 850K DNA Methylation BeadChip. Baseline results indicated that migrants have higher prevalence of CVD risk factors than non-migrants. Epigenome-wide association studies suggest important differences in DNA methylation between migrants and non-migrants. The follow-up study will shed further light on key-specific environmental exposures and epigenetic modifications contributing to the high burden of CVD risk among sub-Saharan African migrants.Future plans Follow-up is planned at 5-year intervals, baseline completed in 2015 and first follow-up completed in 2021.https://bmjopen.bmj.com/content/12/12/e067906.full |
| spellingShingle | Charles Agyemang Ellis Owusu-Dabo Erik Beune Karlijn Meeks Bert-Jan H van den Born Peter Henneman Sampson Twumasi-Ankrah Eva L van der Linden Daniel Antwi-Berko Samuel Nkansah Darko Cohort profile: Research on Obesity and Diabetes among African Migrants in Europe and Africa Prospective (RODAM-Pros) cohort study BMJ Open |
| title | Cohort profile: Research on Obesity and Diabetes among African Migrants in Europe and Africa Prospective (RODAM-Pros) cohort study |
| title_full | Cohort profile: Research on Obesity and Diabetes among African Migrants in Europe and Africa Prospective (RODAM-Pros) cohort study |
| title_fullStr | Cohort profile: Research on Obesity and Diabetes among African Migrants in Europe and Africa Prospective (RODAM-Pros) cohort study |
| title_full_unstemmed | Cohort profile: Research on Obesity and Diabetes among African Migrants in Europe and Africa Prospective (RODAM-Pros) cohort study |
| title_short | Cohort profile: Research on Obesity and Diabetes among African Migrants in Europe and Africa Prospective (RODAM-Pros) cohort study |
| title_sort | cohort profile research on obesity and diabetes among african migrants in europe and africa prospective rodam pros cohort study |
| url | https://bmjopen.bmj.com/content/12/12/e067906.full |
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