In-situ biophysical characterization of high-concentration protein formulations using wNMR

In-situ biophysical characterization of high-concentration protein formulations using wNMR

High-concentration protein formulation is of paramount importance in patient-centric drug product development, but it also presents challenges due to the potential for enhanced aggregation and increased viscosity. The analysis of critical quality attributes often necessitates the transfer of samples...

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Bibliographic Details
Main Authors: Jing Song, Marc Taraban, Y. Bruce Yu, Lynn Lu, Pallavi Guha Biswas, Wei Xu, Hanmi Xi, Akhilesh Bhambhani, Guangli Hu, Yongchao Su
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Accelerated stress
biologics
drug product stability
high-concentration drug product
mABs
protein aggregation
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2304624
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