Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zone
Summary: Neurogenesis and gliogenesis continue in the ventricular-subventricular zone (V-SVZ) of the adult rodent brain. V-SVZ astroglial cells with apical contact with the ventricle (B1 cells) function as neural stem cells (NSCs). B1 cells sharply decline during early postnatal life; in contrast, n...
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Elsevier
2025-03-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221112472500035X |
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| author | Arantxa Cebrian-Silla Marcos Assis Nascimento Walter Mancia Susana Gonzalez-Granero Ricardo Romero-Rodriguez Kirsten Obernier David M. Steffen Daniel.A. Lim Jose Manuel Garcia-Verdugo Arturo Alvarez-Buylla |
| author_facet | Arantxa Cebrian-Silla Marcos Assis Nascimento Walter Mancia Susana Gonzalez-Granero Ricardo Romero-Rodriguez Kirsten Obernier David M. Steffen Daniel.A. Lim Jose Manuel Garcia-Verdugo Arturo Alvarez-Buylla |
| author_sort | Arantxa Cebrian-Silla |
| collection | DOAJ |
| description | Summary: Neurogenesis and gliogenesis continue in the ventricular-subventricular zone (V-SVZ) of the adult rodent brain. V-SVZ astroglial cells with apical contact with the ventricle (B1 cells) function as neural stem cells (NSCs). B1 cells sharply decline during early postnatal life; in contrast, neurogenesis decreases at a slower rate. Here, we show that a second population of astroglia (B2 cells) that do not contact the ventricle also function as NSCs in the adult mouse brain. B2 cell numbers increase postnatally, are sustained in adults, and decrease with aging. We reveal the transcriptomic profile of B1 and B2 cells and show that, like B1 cells, B2 cells can be quiescent or activated. Transplantation and lineage tracing of B2 cells demonstrate their function as primary progenitors for adult neurogenesis. This study reveals that NSC function is progressively relayed from B1 to B2 progenitors helping explain how neurogenesis is maintained into adult life. |
| format | Article |
| id | doaj-art-8d8e3bf8ee6a44a0b7d0af9c17ee0570 |
| institution | OA Journals |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-8d8e3bf8ee6a44a0b7d0af9c17ee05702025-08-20T02:11:05ZengElsevierCell Reports2211-12472025-03-0144311526410.1016/j.celrep.2025.115264Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zoneArantxa Cebrian-Silla0Marcos Assis Nascimento1Walter Mancia2Susana Gonzalez-Granero3Ricardo Romero-Rodriguez4Kirsten Obernier5David M. Steffen6Daniel.A. Lim7Jose Manuel Garcia-Verdugo8Arturo Alvarez-Buylla9Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Corresponding authorEli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USAEli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USABTELab, Research Foundation of the General University Hospital of Valencia, Valencia 46014, SpainEli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USAQuantitative Biosciences Institute, University of California, San Francisco (UCSF), San Francisco, CA, USAEli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USAEli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USALaboratory of Comparative Neurobiology, Cavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia and CIBERNED-ISCIII, Paterna, 46980 Valencia, SpainEli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Corresponding authorSummary: Neurogenesis and gliogenesis continue in the ventricular-subventricular zone (V-SVZ) of the adult rodent brain. V-SVZ astroglial cells with apical contact with the ventricle (B1 cells) function as neural stem cells (NSCs). B1 cells sharply decline during early postnatal life; in contrast, neurogenesis decreases at a slower rate. Here, we show that a second population of astroglia (B2 cells) that do not contact the ventricle also function as NSCs in the adult mouse brain. B2 cell numbers increase postnatally, are sustained in adults, and decrease with aging. We reveal the transcriptomic profile of B1 and B2 cells and show that, like B1 cells, B2 cells can be quiescent or activated. Transplantation and lineage tracing of B2 cells demonstrate their function as primary progenitors for adult neurogenesis. This study reveals that NSC function is progressively relayed from B1 to B2 progenitors helping explain how neurogenesis is maintained into adult life.http://www.sciencedirect.com/science/article/pii/S221112472500035XCP: Neuroscience |
| spellingShingle | Arantxa Cebrian-Silla Marcos Assis Nascimento Walter Mancia Susana Gonzalez-Granero Ricardo Romero-Rodriguez Kirsten Obernier David M. Steffen Daniel.A. Lim Jose Manuel Garcia-Verdugo Arturo Alvarez-Buylla Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zone Cell Reports CP: Neuroscience |
| title | Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zone |
| title_full | Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zone |
| title_fullStr | Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zone |
| title_full_unstemmed | Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zone |
| title_short | Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zone |
| title_sort | neural stem cell relay from b1 to b2 cells in the adult mouse ventricular subventricular zone |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S221112472500035X |
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