Evaluation of the effect of black radish juice on the treatment or prevention of stone formation induced by ethylene glycol in rat
Ethylene glycol (EG)-induced urolithiasis is a common type of kidney stone formation that is caused by the metabolism of EG to oxalate. Black radish juice has been shown to have antioxidant and anti-inflammatory properties, which may be beneficial in treating or preventing kidney stones. The study...
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Universidade Estadual de Maringá
2025-07-01
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| Series: | Acta Scientiarum. Health Sciences |
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| Online Access: | https://periodicos.uem.br/ojs/index.php/ActaSciHealthSci/article/view/72648 |
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| author | Mojtaba Komeili Freshteh Osmani Mohammad Malekane Sayyedeh Fatemeh Askari Reza Ilkhani |
| author_facet | Mojtaba Komeili Freshteh Osmani Mohammad Malekane Sayyedeh Fatemeh Askari Reza Ilkhani |
| author_sort | Mojtaba Komeili |
| collection | DOAJ |
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Ethylene glycol (EG)-induced urolithiasis is a common type of kidney stone formation that is caused by the metabolism of EG to oxalate. Black radish juice has been shown to have antioxidant and anti-inflammatory properties, which may be beneficial in treating or preventing kidney stones. The study aimed to investigate the effects of black radish juice on the treatment and prevention of ethylene glycol-induced urolithiasis in rats. Forty-eight wester rats were randomly divided into six groups of 8 and treated with ethylene glycol alone, ethylene glycol + black radish juice, or served as controls. Black radish juice was found to significantly increase urine flow and pH, decrease crystal content in the urine, and reduce the number and size of calcium oxalate crystals in the kidneys of rats. There were also measurable changes in blood levels of AST, ALT, and calcium. However, urine pH levels decreased significantly in the model group, while oxalate levels remained unchanged across all groups. The study suggests that black radish juice may have a protective effect against ethylene glycol-induced urolithiasis in rats, but acknowledges the limitations in study design and ethical concerns. The findings cannot definitively claim the effectiveness of black radish juice in the prevention or treatment of kidney stones.
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| format | Article |
| id | doaj-art-8d8afde8c1e242e495d59ec5ed2e0185 |
| institution | OA Journals |
| issn | 1679-9291 1807-8648 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Universidade Estadual de Maringá |
| record_format | Article |
| series | Acta Scientiarum. Health Sciences |
| spelling | doaj-art-8d8afde8c1e242e495d59ec5ed2e01852025-08-20T02:35:47ZengUniversidade Estadual de MaringáActa Scientiarum. Health Sciences1679-92911807-86482025-07-0147110.4025/actascihealthsci.v47i1.72648Evaluation of the effect of black radish juice on the treatment or prevention of stone formation induced by ethylene glycol in ratMojtaba Komeili0Freshteh Osmani1Mohammad Malekane2Sayyedeh Fatemeh Askari3Reza Ilkhani4Birjand University of Medical SciencesTorbat Heydariyeh University of Medical SciencesBirjand University of Medical SciencesBirjand University of Medical SciencesBirjand University of Medical Sciences Ethylene glycol (EG)-induced urolithiasis is a common type of kidney stone formation that is caused by the metabolism of EG to oxalate. Black radish juice has been shown to have antioxidant and anti-inflammatory properties, which may be beneficial in treating or preventing kidney stones. The study aimed to investigate the effects of black radish juice on the treatment and prevention of ethylene glycol-induced urolithiasis in rats. Forty-eight wester rats were randomly divided into six groups of 8 and treated with ethylene glycol alone, ethylene glycol + black radish juice, or served as controls. Black radish juice was found to significantly increase urine flow and pH, decrease crystal content in the urine, and reduce the number and size of calcium oxalate crystals in the kidneys of rats. There were also measurable changes in blood levels of AST, ALT, and calcium. However, urine pH levels decreased significantly in the model group, while oxalate levels remained unchanged across all groups. The study suggests that black radish juice may have a protective effect against ethylene glycol-induced urolithiasis in rats, but acknowledges the limitations in study design and ethical concerns. The findings cannot definitively claim the effectiveness of black radish juice in the prevention or treatment of kidney stones. https://periodicos.uem.br/ojs/index.php/ActaSciHealthSci/article/view/72648Traditional medicine; black horseradish; rat wester; ethylene glycol; kidney stones. |
| spellingShingle | Mojtaba Komeili Freshteh Osmani Mohammad Malekane Sayyedeh Fatemeh Askari Reza Ilkhani Evaluation of the effect of black radish juice on the treatment or prevention of stone formation induced by ethylene glycol in rat Acta Scientiarum. Health Sciences Traditional medicine; black horseradish; rat wester; ethylene glycol; kidney stones. |
| title | Evaluation of the effect of black radish juice on the treatment or prevention of stone formation induced by ethylene glycol in rat |
| title_full | Evaluation of the effect of black radish juice on the treatment or prevention of stone formation induced by ethylene glycol in rat |
| title_fullStr | Evaluation of the effect of black radish juice on the treatment or prevention of stone formation induced by ethylene glycol in rat |
| title_full_unstemmed | Evaluation of the effect of black radish juice on the treatment or prevention of stone formation induced by ethylene glycol in rat |
| title_short | Evaluation of the effect of black radish juice on the treatment or prevention of stone formation induced by ethylene glycol in rat |
| title_sort | evaluation of the effect of black radish juice on the treatment or prevention of stone formation induced by ethylene glycol in rat |
| topic | Traditional medicine; black horseradish; rat wester; ethylene glycol; kidney stones. |
| url | https://periodicos.uem.br/ojs/index.php/ActaSciHealthSci/article/view/72648 |
| work_keys_str_mv | AT mojtabakomeili evaluationoftheeffectofblackradishjuiceonthetreatmentorpreventionofstoneformationinducedbyethyleneglycolinrat AT freshtehosmani evaluationoftheeffectofblackradishjuiceonthetreatmentorpreventionofstoneformationinducedbyethyleneglycolinrat AT mohammadmalekane evaluationoftheeffectofblackradishjuiceonthetreatmentorpreventionofstoneformationinducedbyethyleneglycolinrat AT sayyedehfatemehaskari evaluationoftheeffectofblackradishjuiceonthetreatmentorpreventionofstoneformationinducedbyethyleneglycolinrat AT rezailkhani evaluationoftheeffectofblackradishjuiceonthetreatmentorpreventionofstoneformationinducedbyethyleneglycolinrat |