Cardiovascular injury and clinical features of multisystem inflammatory syndrome in children (MIS-C) related to Covid-19 in Vietnam
Background: This study aimed to describe the cardiovascular injury and clinical features of multisystem inflammatory syndrome in children (MIS-C) related to coronavirus disease 2019 (COVID-19) in Ho Chi Minh City, Vietnam. Methods: This was a retrospective cohort study of children with MIS-C (from S...
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Elsevier
2022-11-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957222001449 |
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| author | Nguyen The Nguyen Phung Thanh Thuc Tran Thanh Hung Nguyen Tri Hao Nguyen Thi Mai Thao Nguyen |
| author_facet | Nguyen The Nguyen Phung Thanh Thuc Tran Thanh Hung Nguyen Tri Hao Nguyen Thi Mai Thao Nguyen |
| author_sort | Nguyen The Nguyen Phung |
| collection | DOAJ |
| description | Background: This study aimed to describe the cardiovascular injury and clinical features of multisystem inflammatory syndrome in children (MIS-C) related to coronavirus disease 2019 (COVID-19) in Ho Chi Minh City, Vietnam. Methods: This was a retrospective cohort study of children with MIS-C (from September 1, 2021 to February 28, 2022) in Children's Hospital 1, Ho Chi Minh City. Demographics, clinical history, significant underlying conditions, clinical manifestations, laboratory investigations, and medical management were analyzed. Results: A total of 76 patients were included (median age, 5.9 years old, 2 months–16 years). The male/female ratio was 1.6/1. Most patients (75/76) had no previous medical conditions. The mean time from acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to symptom onset was 39 days. During an acute SARS-CoV-2 infection, these patients are either asymptomatic or mildly symptomatic. In addition to fever, gastrointestinal symptoms were also prominent, as observed in our study, with 75%, 73.7%, and 72.3% of patients presenting with abdominal pain, vomiting, and loose stools, respectively. The levels of inflammatory markers increased upon admission and returned to normal levels after treatment. Echocardiography revealed decreased myocardial contractility and coronary injury in 16 (21.1%) and 32 (42.1%) patients, respectively. Most cases (72/76) had no fever within 3 days of intravenous immunoglobulin (IVIG) and methylprednisolone treatment. No deaths occurred in this study. The mean duration of hospitalization was 7.2 days. Conclusion: Cardiovascular involvement was observed in approximately 53.9% of the patients. Anti-inflammatory treatment with IVIG and methylprednisolone had a favorable short-term outcome. However, long-term follow-up studies on post-discharge MIS-C cases are needed to make appropriate treatment recommendations in the acute phase. |
| format | Article |
| id | doaj-art-8d83e93ec7574889bdfeb91cd3d37a8f |
| institution | OA Journals |
| issn | 1875-9572 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-8d83e93ec7574889bdfeb91cd3d37a8f2025-08-20T01:58:30ZengElsevierPediatrics and Neonatology1875-95722022-11-0163656957410.1016/j.pedneo.2022.05.009Cardiovascular injury and clinical features of multisystem inflammatory syndrome in children (MIS-C) related to Covid-19 in VietnamNguyen The Nguyen Phung0Thanh Thuc Tran1Thanh Hung Nguyen2Tri Hao Nguyen3Thi Mai Thao Nguyen4Department of Pediatrics, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam; Children's Hospital 1, Ho Chi Minh City, Viet Nam; Corresponding author. University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang Street, District 5, Ho Chi Minh City, Viet Nam.Department of Pediatrics, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam; Children's Hospital 1, Ho Chi Minh City, Viet NamChildren's Hospital 1, Ho Chi Minh City, Viet Nam; Pediatric Department- School of Medicine, Vietnam National University Ho Chi Minh City, Viet NamChildren's Hospital 1, Ho Chi Minh City, Viet NamDepartment of Pediatrics, University of Medicine and Pharmacy at Ho Chi Minh City, Viet NamBackground: This study aimed to describe the cardiovascular injury and clinical features of multisystem inflammatory syndrome in children (MIS-C) related to coronavirus disease 2019 (COVID-19) in Ho Chi Minh City, Vietnam. Methods: This was a retrospective cohort study of children with MIS-C (from September 1, 2021 to February 28, 2022) in Children's Hospital 1, Ho Chi Minh City. Demographics, clinical history, significant underlying conditions, clinical manifestations, laboratory investigations, and medical management were analyzed. Results: A total of 76 patients were included (median age, 5.9 years old, 2 months–16 years). The male/female ratio was 1.6/1. Most patients (75/76) had no previous medical conditions. The mean time from acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to symptom onset was 39 days. During an acute SARS-CoV-2 infection, these patients are either asymptomatic or mildly symptomatic. In addition to fever, gastrointestinal symptoms were also prominent, as observed in our study, with 75%, 73.7%, and 72.3% of patients presenting with abdominal pain, vomiting, and loose stools, respectively. The levels of inflammatory markers increased upon admission and returned to normal levels after treatment. Echocardiography revealed decreased myocardial contractility and coronary injury in 16 (21.1%) and 32 (42.1%) patients, respectively. Most cases (72/76) had no fever within 3 days of intravenous immunoglobulin (IVIG) and methylprednisolone treatment. No deaths occurred in this study. The mean duration of hospitalization was 7.2 days. Conclusion: Cardiovascular involvement was observed in approximately 53.9% of the patients. Anti-inflammatory treatment with IVIG and methylprednisolone had a favorable short-term outcome. However, long-term follow-up studies on post-discharge MIS-C cases are needed to make appropriate treatment recommendations in the acute phase.http://www.sciencedirect.com/science/article/pii/S1875957222001449cardiovascular injuryCOVID-19MIS-CSARS-CoV-2 |
| spellingShingle | Nguyen The Nguyen Phung Thanh Thuc Tran Thanh Hung Nguyen Tri Hao Nguyen Thi Mai Thao Nguyen Cardiovascular injury and clinical features of multisystem inflammatory syndrome in children (MIS-C) related to Covid-19 in Vietnam Pediatrics and Neonatology cardiovascular injury COVID-19 MIS-C SARS-CoV-2 |
| title | Cardiovascular injury and clinical features of multisystem inflammatory syndrome in children (MIS-C) related to Covid-19 in Vietnam |
| title_full | Cardiovascular injury and clinical features of multisystem inflammatory syndrome in children (MIS-C) related to Covid-19 in Vietnam |
| title_fullStr | Cardiovascular injury and clinical features of multisystem inflammatory syndrome in children (MIS-C) related to Covid-19 in Vietnam |
| title_full_unstemmed | Cardiovascular injury and clinical features of multisystem inflammatory syndrome in children (MIS-C) related to Covid-19 in Vietnam |
| title_short | Cardiovascular injury and clinical features of multisystem inflammatory syndrome in children (MIS-C) related to Covid-19 in Vietnam |
| title_sort | cardiovascular injury and clinical features of multisystem inflammatory syndrome in children mis c related to covid 19 in vietnam |
| topic | cardiovascular injury COVID-19 MIS-C SARS-CoV-2 |
| url | http://www.sciencedirect.com/science/article/pii/S1875957222001449 |
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