TLRs, Alcohol, HCV, and Tumorigenesis
Chronic liver damage caused by viral infection, alcohol, or obesity can result in increased risk for hepatocellular carcinoma (HCC). Ample epidemiological evidence suggests that there is a strong synergism between hepatitis C virus (HCV) and alcoholic liver diseases (ALD). The Toll-like receptor (TL...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/518674 |
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| _version_ | 1832550292800929792 |
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| author | Keigo Machida |
| author_facet | Keigo Machida |
| author_sort | Keigo Machida |
| collection | DOAJ |
| description | Chronic liver damage caused by viral infection, alcohol, or obesity can result in increased risk for hepatocellular carcinoma (HCC). Ample epidemiological evidence suggests that there is a strong synergism between hepatitis C virus (HCV) and alcoholic liver diseases (ALD). The Toll-like receptor (TLR) signaling pathway is upregulated in chronic liver diseases. Alcoholism is associated with endotoxemia that stimulates expression of proinflammatory cytokine expression and inflammation in the liver and fat tissues. Recent studies of HCC have centered on cancer-initiating stem cell (CSC), including detection of CSC in cancer, identification of CSC markers, and isolation of CSC from human HCC cell lines. Synergism between alcohol and HCV may lead to liver tumorigenesis through TLR signaling. |
| format | Article |
| id | doaj-art-8d83b2b0068040fc973325e211a86674 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-8d83b2b0068040fc973325e211a866742025-02-03T06:07:09ZengWileyGastroenterology Research and Practice1687-61211687-630X2010-01-01201010.1155/2010/518674518674TLRs, Alcohol, HCV, and TumorigenesisKeigo Machida0Department of Molecular Microbiology and Immunology, 503B-HMR, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USAChronic liver damage caused by viral infection, alcohol, or obesity can result in increased risk for hepatocellular carcinoma (HCC). Ample epidemiological evidence suggests that there is a strong synergism between hepatitis C virus (HCV) and alcoholic liver diseases (ALD). The Toll-like receptor (TLR) signaling pathway is upregulated in chronic liver diseases. Alcoholism is associated with endotoxemia that stimulates expression of proinflammatory cytokine expression and inflammation in the liver and fat tissues. Recent studies of HCC have centered on cancer-initiating stem cell (CSC), including detection of CSC in cancer, identification of CSC markers, and isolation of CSC from human HCC cell lines. Synergism between alcohol and HCV may lead to liver tumorigenesis through TLR signaling.http://dx.doi.org/10.1155/2010/518674 |
| spellingShingle | Keigo Machida TLRs, Alcohol, HCV, and Tumorigenesis Gastroenterology Research and Practice |
| title | TLRs, Alcohol, HCV, and Tumorigenesis |
| title_full | TLRs, Alcohol, HCV, and Tumorigenesis |
| title_fullStr | TLRs, Alcohol, HCV, and Tumorigenesis |
| title_full_unstemmed | TLRs, Alcohol, HCV, and Tumorigenesis |
| title_short | TLRs, Alcohol, HCV, and Tumorigenesis |
| title_sort | tlrs alcohol hcv and tumorigenesis |
| url | http://dx.doi.org/10.1155/2010/518674 |
| work_keys_str_mv | AT keigomachida tlrsalcoholhcvandtumorigenesis |