From Melanocyte to Metastatic Malignant Melanoma
Malignant melanoma is one of the most aggressive malignancies in human and is responsible for almost 60% of lethal skin tumors. Its incidence has been increasing in white population in the past two decades. There is a complex interaction of environmental (exogenous) and endogenous, including genetic...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/583748 |
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| _version_ | 1832545383137411072 |
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| author | Bizhan Bandarchi Linglei Ma Roya Navab Arun Seth Golnar Rasty |
| author_facet | Bizhan Bandarchi Linglei Ma Roya Navab Arun Seth Golnar Rasty |
| author_sort | Bizhan Bandarchi |
| collection | DOAJ |
| description | Malignant melanoma is one of the most aggressive malignancies in human and is responsible for almost 60% of lethal skin tumors. Its incidence has been increasing in white population in the past two decades. There is a complex interaction of environmental (exogenous) and endogenous, including genetic, risk factors in developing malignant melanoma. 8–12% of familial melanomas occur in a familial setting related to mutation of the CDKN2A gene that encodes p16. The aim of this is to briefly review the microanatomy and physiology of the melanocytes, epidemiology, risk factors, clinical presentation, historical classification and histopathology and, more in details, the most recent discoveries in biology and genetics of malignant melanoma. At the end, the final version of 2009 AJCC malignant melanoma staging and classification is presented. |
| format | Article |
| id | doaj-art-8d81892698d948ac8f9bbf1cd9d00acf |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-8d81892698d948ac8f9bbf1cd9d00acf2025-02-03T07:26:03ZengWileyDermatology Research and Practice1687-61051687-61132010-01-01201010.1155/2010/583748583748From Melanocyte to Metastatic Malignant MelanomaBizhan Bandarchi0Linglei Ma1Roya Navab2Arun Seth3Golnar Rasty4Department of Applied Molecular Oncology, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, 7 Yorkview Drive, Toronto, ON, M2N 2R9, CanadaDepartment of Pathology, University of Michigan Hospital, University of Michigan, Michigan 48109-0602, USADepartment of Applied Molecular Oncology, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, 7 Yorkview Drive, Toronto, ON, M2N 2R9, CanadaDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, M4N 3M5, CanadaDepartment of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, M5G 2C4, CanadaMalignant melanoma is one of the most aggressive malignancies in human and is responsible for almost 60% of lethal skin tumors. Its incidence has been increasing in white population in the past two decades. There is a complex interaction of environmental (exogenous) and endogenous, including genetic, risk factors in developing malignant melanoma. 8–12% of familial melanomas occur in a familial setting related to mutation of the CDKN2A gene that encodes p16. The aim of this is to briefly review the microanatomy and physiology of the melanocytes, epidemiology, risk factors, clinical presentation, historical classification and histopathology and, more in details, the most recent discoveries in biology and genetics of malignant melanoma. At the end, the final version of 2009 AJCC malignant melanoma staging and classification is presented.http://dx.doi.org/10.1155/2010/583748 |
| spellingShingle | Bizhan Bandarchi Linglei Ma Roya Navab Arun Seth Golnar Rasty From Melanocyte to Metastatic Malignant Melanoma Dermatology Research and Practice |
| title | From Melanocyte to Metastatic Malignant Melanoma |
| title_full | From Melanocyte to Metastatic Malignant Melanoma |
| title_fullStr | From Melanocyte to Metastatic Malignant Melanoma |
| title_full_unstemmed | From Melanocyte to Metastatic Malignant Melanoma |
| title_short | From Melanocyte to Metastatic Malignant Melanoma |
| title_sort | from melanocyte to metastatic malignant melanoma |
| url | http://dx.doi.org/10.1155/2010/583748 |
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