Epilepsy and brain health: a large prospective cohort study
Abstract Background Epilepsy, as a chronic noncommunicable disease with recurrent seizures, may be a marker of deterioration or alteration in other underlying neurological diseases. This study aimed to investigate the relationship of epilepsy with brain function, other common brain disorders, and th...
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BMC
2024-12-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-024-06006-9 |
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| author | Dan-Dan Zhang Zi-Yi Wang Ya-Ru Zhang Pei-Yang Gao Wei Zhang Yan Fu Hao-Chen Chi Li-Yun Ma Yi-Jun Ge Xiao-Yu He Jia You Wei Cheng Jian-Feng Feng Lan Tan Jin-Tai Yu |
| author_facet | Dan-Dan Zhang Zi-Yi Wang Ya-Ru Zhang Pei-Yang Gao Wei Zhang Yan Fu Hao-Chen Chi Li-Yun Ma Yi-Jun Ge Xiao-Yu He Jia You Wei Cheng Jian-Feng Feng Lan Tan Jin-Tai Yu |
| author_sort | Dan-Dan Zhang |
| collection | DOAJ |
| description | Abstract Background Epilepsy, as a chronic noncommunicable disease with recurrent seizures, may be a marker of deterioration or alteration in other underlying neurological diseases. This study aimed to investigate the relationship of epilepsy with brain function, other common brain disorders, and their underlying mechanisms. Methods The study was based on clinical diagnostic and test data from 426,527 participants in the UK Biobank, of whom 3,251 were diagnosed with epilepsy at baseline. Multiple linear and Cox regression models were used to explore the association between epilepsy, brain function, and other brain disorders. Results This study demonstrated consistent deleterious effects of epilepsy on cognitive and motor function and mental health. The risk of neurological diseases and psychiatric disorders was significantly elevated in the epilepsy population during the 17-year follow-up period, according to the longitudinal analysis. We also identified several brain regions associated with epilepsy, including the pallidum, hippocampus, and precentral regions. Mediation analyses revealed mediating effects of peripheral markers and proteins (e.g., GGT, HDL, ACE2, and GDF15), suggesting that liver function and lipid metabolism may be involved in the development of other brain disorders in individuals with epilepsy. Conclusions Our study provides robust evidence of the association between epilepsy and poor brain health, underscoring the importance of early intervention for epilepsy. |
| format | Article |
| id | doaj-art-8d8139a35c5248cdaf5a8d6cf0246414 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-8d8139a35c5248cdaf5a8d6cf02464142025-01-05T12:44:27ZengBMCJournal of Translational Medicine1479-58762024-12-0122111410.1186/s12967-024-06006-9Epilepsy and brain health: a large prospective cohort studyDan-Dan Zhang0Zi-Yi Wang1Ya-Ru Zhang2Pei-Yang Gao3Wei Zhang4Yan Fu5Hao-Chen Chi6Li-Yun Ma7Yi-Jun Ge8Xiao-Yu He9Jia You10Wei Cheng11Jian-Feng Feng12Lan Tan13Jin-Tai Yu14Department of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Huashan Hospital, Fudan UniversityDepartment of Neurology and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Huashan Hospital, Fudan UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityInstitute of Science and Technology for Brain-inspired Intelligence, Fudan UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Huashan Hospital, Fudan UniversityDepartment of Neurology and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Huashan Hospital, Fudan UniversityInstitute of Science and Technology for Brain-inspired Intelligence, Fudan UniversityDepartment of Neurology and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Huashan Hospital, Fudan UniversityInstitute of Science and Technology for Brain-inspired Intelligence, Fudan UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Huashan Hospital, Fudan UniversityAbstract Background Epilepsy, as a chronic noncommunicable disease with recurrent seizures, may be a marker of deterioration or alteration in other underlying neurological diseases. This study aimed to investigate the relationship of epilepsy with brain function, other common brain disorders, and their underlying mechanisms. Methods The study was based on clinical diagnostic and test data from 426,527 participants in the UK Biobank, of whom 3,251 were diagnosed with epilepsy at baseline. Multiple linear and Cox regression models were used to explore the association between epilepsy, brain function, and other brain disorders. Results This study demonstrated consistent deleterious effects of epilepsy on cognitive and motor function and mental health. The risk of neurological diseases and psychiatric disorders was significantly elevated in the epilepsy population during the 17-year follow-up period, according to the longitudinal analysis. We also identified several brain regions associated with epilepsy, including the pallidum, hippocampus, and precentral regions. Mediation analyses revealed mediating effects of peripheral markers and proteins (e.g., GGT, HDL, ACE2, and GDF15), suggesting that liver function and lipid metabolism may be involved in the development of other brain disorders in individuals with epilepsy. Conclusions Our study provides robust evidence of the association between epilepsy and poor brain health, underscoring the importance of early intervention for epilepsy.https://doi.org/10.1186/s12967-024-06006-9EpilepsyCognitiveMental healthDementiaDepressionMechanism |
| spellingShingle | Dan-Dan Zhang Zi-Yi Wang Ya-Ru Zhang Pei-Yang Gao Wei Zhang Yan Fu Hao-Chen Chi Li-Yun Ma Yi-Jun Ge Xiao-Yu He Jia You Wei Cheng Jian-Feng Feng Lan Tan Jin-Tai Yu Epilepsy and brain health: a large prospective cohort study Journal of Translational Medicine Epilepsy Cognitive Mental health Dementia Depression Mechanism |
| title | Epilepsy and brain health: a large prospective cohort study |
| title_full | Epilepsy and brain health: a large prospective cohort study |
| title_fullStr | Epilepsy and brain health: a large prospective cohort study |
| title_full_unstemmed | Epilepsy and brain health: a large prospective cohort study |
| title_short | Epilepsy and brain health: a large prospective cohort study |
| title_sort | epilepsy and brain health a large prospective cohort study |
| topic | Epilepsy Cognitive Mental health Dementia Depression Mechanism |
| url | https://doi.org/10.1186/s12967-024-06006-9 |
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