The association of sexual frequency with cardiovascular diseases incidence and all-cause mortality
Abstract Sexual activity exists in a complex relationship with human health. This study aims to elucidate the correlation between the sexual frequency and the incidence of cardiovascular diseases (CVD) and all-cause mortality among young and middle-aged adults of the United States. We analyzed 17,24...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-83414-3 |
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| author | Tian-Qi Teng Jing Liu Meng-Meng Wang De-Gang Mo Rui Chen Jia-Chao Xu Zi-Han Dong Ning Zhang Hai-Chu Yu |
| author_facet | Tian-Qi Teng Jing Liu Meng-Meng Wang De-Gang Mo Rui Chen Jia-Chao Xu Zi-Han Dong Ning Zhang Hai-Chu Yu |
| author_sort | Tian-Qi Teng |
| collection | DOAJ |
| description | Abstract Sexual activity exists in a complex relationship with human health. This study aims to elucidate the correlation between the sexual frequency and the incidence of cardiovascular diseases (CVD) and all-cause mortality among young and middle-aged adults of the United States. We analyzed 17,243 participants from the National Health and Nutrition Examination Survey(NHANES)(2005–2016), comparing CVD incidence and all-cause mortality risks across sexual frequencies using multivariable Logistic and Cox regression models. Kaplan-Meier curves assessed survival probability stratified by sexual frequency, and a restricted cubic spline regression examined the nonlinear relationship between sexual frequency, CVD and survival status. We also established a nomogram and validated it by ROC and calibration curves. Over a median follow-up period of 106 months, 443 patients (2.57%) died. After adjusting for confounders, sexual frequency was found to be associated with CVD incidence and all-cause mortality among young and middle-aged individuals. Those with sexual acts less than 12 times/year faced the highest risks of CVD incidence and all-cause mortality, as frequency increased, the risks gradually decreased, reaching a nadir at approximately 52–103 times/year, but then a negative correlation began to emerge. A nomogram predicting survival rates based on sexual frequency achieved ROC areas of 0.782, 0.807, and 0.803 for 3, 5, and 10 years, with a calibration curve matching the ideal generally. Sexual frequency was associated with the incidence of CVD and all-cause mortality among young and middle-aged adults. Both excessive and infrequent sexual frequency may be detrimental to health. |
| format | Article |
| id | doaj-art-8d771c4441cc436cae5f7e484e625ca7 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-8d771c4441cc436cae5f7e484e625ca72025-01-05T12:28:10ZengNature PortfolioScientific Reports2045-23222024-12-0114111310.1038/s41598-024-83414-3The association of sexual frequency with cardiovascular diseases incidence and all-cause mortalityTian-Qi Teng0Jing Liu1Meng-Meng Wang2De-Gang Mo3Rui Chen4Jia-Chao Xu5Zi-Han Dong6Ning Zhang7Hai-Chu Yu8Department of Cardiology, The Affiliated Hospital of Qingdao UniversityDepartment of Neurology, Xuzhou New Health Geriatric HospitalDepartment of Cardiology, The Affiliated Hospital of Qingdao UniversityDepartment of Cardiology, The Affiliated Hospital of Qingdao UniversityDepartment of Cardiology, The Affiliated Hospital of Qingdao UniversityDepartment of Cardiology, The Affiliated Hospital of Qingdao UniversityDepartment of Cardiology, The Affiliated Hospital of Qingdao UniversityDepartment of Cardiology, The Affiliated Hospital of Qingdao UniversityDepartment of Cardiology, The Affiliated Hospital of Qingdao UniversityAbstract Sexual activity exists in a complex relationship with human health. This study aims to elucidate the correlation between the sexual frequency and the incidence of cardiovascular diseases (CVD) and all-cause mortality among young and middle-aged adults of the United States. We analyzed 17,243 participants from the National Health and Nutrition Examination Survey(NHANES)(2005–2016), comparing CVD incidence and all-cause mortality risks across sexual frequencies using multivariable Logistic and Cox regression models. Kaplan-Meier curves assessed survival probability stratified by sexual frequency, and a restricted cubic spline regression examined the nonlinear relationship between sexual frequency, CVD and survival status. We also established a nomogram and validated it by ROC and calibration curves. Over a median follow-up period of 106 months, 443 patients (2.57%) died. After adjusting for confounders, sexual frequency was found to be associated with CVD incidence and all-cause mortality among young and middle-aged individuals. Those with sexual acts less than 12 times/year faced the highest risks of CVD incidence and all-cause mortality, as frequency increased, the risks gradually decreased, reaching a nadir at approximately 52–103 times/year, but then a negative correlation began to emerge. A nomogram predicting survival rates based on sexual frequency achieved ROC areas of 0.782, 0.807, and 0.803 for 3, 5, and 10 years, with a calibration curve matching the ideal generally. Sexual frequency was associated with the incidence of CVD and all-cause mortality among young and middle-aged adults. Both excessive and infrequent sexual frequency may be detrimental to health.https://doi.org/10.1038/s41598-024-83414-3Sexual frequencyCardiovascular diseasesAll-cause mortalityNHANESYoung and middle-aged adults |
| spellingShingle | Tian-Qi Teng Jing Liu Meng-Meng Wang De-Gang Mo Rui Chen Jia-Chao Xu Zi-Han Dong Ning Zhang Hai-Chu Yu The association of sexual frequency with cardiovascular diseases incidence and all-cause mortality Scientific Reports Sexual frequency Cardiovascular diseases All-cause mortality NHANES Young and middle-aged adults |
| title | The association of sexual frequency with cardiovascular diseases incidence and all-cause mortality |
| title_full | The association of sexual frequency with cardiovascular diseases incidence and all-cause mortality |
| title_fullStr | The association of sexual frequency with cardiovascular diseases incidence and all-cause mortality |
| title_full_unstemmed | The association of sexual frequency with cardiovascular diseases incidence and all-cause mortality |
| title_short | The association of sexual frequency with cardiovascular diseases incidence and all-cause mortality |
| title_sort | association of sexual frequency with cardiovascular diseases incidence and all cause mortality |
| topic | Sexual frequency Cardiovascular diseases All-cause mortality NHANES Young and middle-aged adults |
| url | https://doi.org/10.1038/s41598-024-83414-3 |
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