Nonalcoholic Fatty Liver Disease and Coronary Artery Disease: Big Brothers in Patients with Acute Coronary Syndrome
Background. The prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing. This study aimed to evaluate the prevalence of NAFLD, as diagnosed by ultrasound, in patients with acute coronary syndrome (ACS) and to assess whether NAFLD is associated with the severity of coronary obstruc...
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Wiley
2020-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2020/8489238 |
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| author | Mauricio Montemezzo Ahmed AlTurki Fabio Stahlschmidt Marcia Olandoski Jean Rodrigo Tafarel Dalton Bertolin Precoma |
| author_facet | Mauricio Montemezzo Ahmed AlTurki Fabio Stahlschmidt Marcia Olandoski Jean Rodrigo Tafarel Dalton Bertolin Precoma |
| author_sort | Mauricio Montemezzo |
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| description | Background. The prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing. This study aimed to evaluate the prevalence of NAFLD, as diagnosed by ultrasound, in patients with acute coronary syndrome (ACS) and to assess whether NAFLD is associated with the severity of coronary obstruction as diagnosed by coronary angiography. Methods. We performed a prospective single-center study in patients hospitalized due to acute coronary syndrome who underwent diagnostic coronary angiography. Consecutive patients who presented to the emergency room were diagnosed with acute coronary syndrome and were included. All patients underwent ultrasonography of the upper abdomen to determine the presence or absence of NAFLD; NAFLD severity was graded from 0 to 3 based on a previously validated scale. All patients underwent diagnostic coronary angiography in the same hospital, with the same team of interventional cardiologists, who were blinded to the patients’ clinical and ultrasonographic data. CAD was then angiographically graded from none to severe based on well-established angiographic criteria. Results. This study included 139 patients, of whom 83 (59.7%) were male, with a mean age of 59.7 years. Of the included patients, 107 (77%) patients had CAD, 63 (45%) with serious injury. Regarding the presence of NAFLD, 76 (55.2%) had NAFLD including 18 (23.6%) with grade III disease. In severe CAD, 47 (60.5%) are associated with NAFLD, and 15 (83.3%) of the patients had severe CAD and NAFLD grade III. Conclusions. NAFLD is common in patients with ACS. The intensity of NAFLD detected by ultrasonography is strongly associated with the severity of coronary artery obstruction on angiography. |
| format | Article |
| id | doaj-art-8d76e9347f3a4e02a81cc08af4a0f6ff |
| institution | OA Journals |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-8d76e9347f3a4e02a81cc08af4a0f6ff2025-08-20T02:09:41ZengWileyThe Scientific World Journal2356-61401537-744X2020-01-01202010.1155/2020/84892388489238Nonalcoholic Fatty Liver Disease and Coronary Artery Disease: Big Brothers in Patients with Acute Coronary SyndromeMauricio Montemezzo0Ahmed AlTurki1Fabio Stahlschmidt2Marcia Olandoski3Jean Rodrigo Tafarel4Dalton Bertolin Precoma5Department of Internal Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, BrazilDivision of Cardiology, McGill University Health Center, Montreal, CanadaDepartment of Internal Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, BrazilDepartment of Internal Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, BrazilDepartment of Internal Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, BrazilDepartment of Internal Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, BrazilBackground. The prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing. This study aimed to evaluate the prevalence of NAFLD, as diagnosed by ultrasound, in patients with acute coronary syndrome (ACS) and to assess whether NAFLD is associated with the severity of coronary obstruction as diagnosed by coronary angiography. Methods. We performed a prospective single-center study in patients hospitalized due to acute coronary syndrome who underwent diagnostic coronary angiography. Consecutive patients who presented to the emergency room were diagnosed with acute coronary syndrome and were included. All patients underwent ultrasonography of the upper abdomen to determine the presence or absence of NAFLD; NAFLD severity was graded from 0 to 3 based on a previously validated scale. All patients underwent diagnostic coronary angiography in the same hospital, with the same team of interventional cardiologists, who were blinded to the patients’ clinical and ultrasonographic data. CAD was then angiographically graded from none to severe based on well-established angiographic criteria. Results. This study included 139 patients, of whom 83 (59.7%) were male, with a mean age of 59.7 years. Of the included patients, 107 (77%) patients had CAD, 63 (45%) with serious injury. Regarding the presence of NAFLD, 76 (55.2%) had NAFLD including 18 (23.6%) with grade III disease. In severe CAD, 47 (60.5%) are associated with NAFLD, and 15 (83.3%) of the patients had severe CAD and NAFLD grade III. Conclusions. NAFLD is common in patients with ACS. The intensity of NAFLD detected by ultrasonography is strongly associated with the severity of coronary artery obstruction on angiography.http://dx.doi.org/10.1155/2020/8489238 |
| spellingShingle | Mauricio Montemezzo Ahmed AlTurki Fabio Stahlschmidt Marcia Olandoski Jean Rodrigo Tafarel Dalton Bertolin Precoma Nonalcoholic Fatty Liver Disease and Coronary Artery Disease: Big Brothers in Patients with Acute Coronary Syndrome The Scientific World Journal |
| title | Nonalcoholic Fatty Liver Disease and Coronary Artery Disease: Big Brothers in Patients with Acute Coronary Syndrome |
| title_full | Nonalcoholic Fatty Liver Disease and Coronary Artery Disease: Big Brothers in Patients with Acute Coronary Syndrome |
| title_fullStr | Nonalcoholic Fatty Liver Disease and Coronary Artery Disease: Big Brothers in Patients with Acute Coronary Syndrome |
| title_full_unstemmed | Nonalcoholic Fatty Liver Disease and Coronary Artery Disease: Big Brothers in Patients with Acute Coronary Syndrome |
| title_short | Nonalcoholic Fatty Liver Disease and Coronary Artery Disease: Big Brothers in Patients with Acute Coronary Syndrome |
| title_sort | nonalcoholic fatty liver disease and coronary artery disease big brothers in patients with acute coronary syndrome |
| url | http://dx.doi.org/10.1155/2020/8489238 |
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