Innovative Strategies in the Diagnosis and Treatment of Liver Cirrhosis and Associated Syndromes
Liver cirrhosis continues to be a major global health issue, contributing to high morbidity and mortality due to its progressive nature and associated complications. This review explores recent advancements in the diagnosis and treatment of liver cirrhosis and its related syndromes. Non-invasive dia...
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MDPI AG
2025-05-01
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| author | Ashok Kumar Sah Mohd Afzal Rabab H. Elshaikh Anass M. Abbas Manar G. Shalabi Pranav Kumar Prabhakar Asaad M. A. Babker Fariza Tursunbaevna Khalimova Velilyaeva Aliya Sabrievna Ranjay Kumar Choudhary |
| author_facet | Ashok Kumar Sah Mohd Afzal Rabab H. Elshaikh Anass M. Abbas Manar G. Shalabi Pranav Kumar Prabhakar Asaad M. A. Babker Fariza Tursunbaevna Khalimova Velilyaeva Aliya Sabrievna Ranjay Kumar Choudhary |
| author_sort | Ashok Kumar Sah |
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| description | Liver cirrhosis continues to be a major global health issue, contributing to high morbidity and mortality due to its progressive nature and associated complications. This review explores recent advancements in the diagnosis and treatment of liver cirrhosis and its related syndromes. Non-invasive diagnostic tools, such as elastography and serum biomarkers, have significantly improved early detection, reducing the need for liver biopsies. Advanced imaging techniques, including MRI and CT, further enhance diagnostic accuracy. In parallel, molecular and genomic research is providing new insights into the pathogenesis of the disease, paving the way for precision medicine. On the treatment front, pharmacological innovations, such as antifibrotic agents and targeted therapies, show promise in slowing disease progression. Endoscopic interventions like variceal banding are improving the management of complications, while advancements in liver transplantation and artificial liver support systems offer life-saving alternatives. Regenerative medicine, particularly stem cell therapy and tissue engineering, is emerging as a promising strategy for liver repair. Managing cirrhosis-related syndromes, including portal hypertension, ascites, hepatic encephalopathy, and hepatorenal syndrome, now involves evolving therapeutic approaches such as transjugular intrahepatic portosystemic shunt (TIPS) and novel pharmacotherapies. Prognostic scoring systems like the MELD and Child–Pugh are being refined with new biomarkers for better risk stratification. The future of cirrhosis care will likely involve the integration of artificial intelligence and machine learning for early diagnosis and personalized treatments, alongside emerging therapies currently under investigation. Despite these advancements, challenges such as costs, accessibility, and healthcare disparities remain barriers to widespread adoption. This review highlights the importance of incorporating innovative diagnostic and therapeutic strategies into clinical practice to improve the outcomes for patients with liver cirrhosis and its complications. |
| format | Article |
| id | doaj-art-8d7240d17afd4ac59bce3f60f86f682c |
| institution | OA Journals |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-8d7240d17afd4ac59bce3f60f86f682c2025-08-20T01:56:31ZengMDPI AGLife2075-17292025-05-0115577910.3390/life15050779Innovative Strategies in the Diagnosis and Treatment of Liver Cirrhosis and Associated SyndromesAshok Kumar Sah0Mohd Afzal1Rabab H. Elshaikh2Anass M. Abbas3Manar G. Shalabi4Pranav Kumar Prabhakar5Asaad M. A. Babker6Fariza Tursunbaevna Khalimova7Velilyaeva Aliya Sabrievna8Ranjay Kumar Choudhary9Department of Medical Laboratory Sciences, College of Applied and Health Sciences, A’ Sharqiyah University, Ibra 400, OmanDepartment of Medical Laboratory Technology, Arogyam Institute of Paramedical & Allied Sciences (Affiliated to H.N.B. Uttarakhand Medical Education University), Roorkee 247661, IndiaDepartment of Medical Laboratory Sciences, College of Applied and Health Sciences, A’ Sharqiyah University, Ibra 400, OmanDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi ArabiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi ArabiaDepartment of Biotechnology, School of Engineering and Technology, Nagaland University, Meriema, Kohima 797004, IndiaDepartment of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman 4184, United Arab EmiratesDepartment of Normal Physiology, Medical and Social Institute of Tajikistan, Dushanbe 734017, TajikistanDepartment of Psychiatry, Medical Psychology, and Narcology, Samarkand State Medical University, Samarkand 140158, UzbekistanDepartment of Medical Laboratory Technology, University Institute of Allied Health Sciences, Chandigarh University, Chandigarh 140413, IndiaLiver cirrhosis continues to be a major global health issue, contributing to high morbidity and mortality due to its progressive nature and associated complications. This review explores recent advancements in the diagnosis and treatment of liver cirrhosis and its related syndromes. Non-invasive diagnostic tools, such as elastography and serum biomarkers, have significantly improved early detection, reducing the need for liver biopsies. Advanced imaging techniques, including MRI and CT, further enhance diagnostic accuracy. In parallel, molecular and genomic research is providing new insights into the pathogenesis of the disease, paving the way for precision medicine. On the treatment front, pharmacological innovations, such as antifibrotic agents and targeted therapies, show promise in slowing disease progression. Endoscopic interventions like variceal banding are improving the management of complications, while advancements in liver transplantation and artificial liver support systems offer life-saving alternatives. Regenerative medicine, particularly stem cell therapy and tissue engineering, is emerging as a promising strategy for liver repair. Managing cirrhosis-related syndromes, including portal hypertension, ascites, hepatic encephalopathy, and hepatorenal syndrome, now involves evolving therapeutic approaches such as transjugular intrahepatic portosystemic shunt (TIPS) and novel pharmacotherapies. Prognostic scoring systems like the MELD and Child–Pugh are being refined with new biomarkers for better risk stratification. The future of cirrhosis care will likely involve the integration of artificial intelligence and machine learning for early diagnosis and personalized treatments, alongside emerging therapies currently under investigation. Despite these advancements, challenges such as costs, accessibility, and healthcare disparities remain barriers to widespread adoption. This review highlights the importance of incorporating innovative diagnostic and therapeutic strategies into clinical practice to improve the outcomes for patients with liver cirrhosis and its complications.https://www.mdpi.com/2075-1729/15/5/779liver cirrhosisinnovative diagnosticstargeted therapiesregenerative medicineprognostic scoring |
| spellingShingle | Ashok Kumar Sah Mohd Afzal Rabab H. Elshaikh Anass M. Abbas Manar G. Shalabi Pranav Kumar Prabhakar Asaad M. A. Babker Fariza Tursunbaevna Khalimova Velilyaeva Aliya Sabrievna Ranjay Kumar Choudhary Innovative Strategies in the Diagnosis and Treatment of Liver Cirrhosis and Associated Syndromes Life liver cirrhosis innovative diagnostics targeted therapies regenerative medicine prognostic scoring |
| title | Innovative Strategies in the Diagnosis and Treatment of Liver Cirrhosis and Associated Syndromes |
| title_full | Innovative Strategies in the Diagnosis and Treatment of Liver Cirrhosis and Associated Syndromes |
| title_fullStr | Innovative Strategies in the Diagnosis and Treatment of Liver Cirrhosis and Associated Syndromes |
| title_full_unstemmed | Innovative Strategies in the Diagnosis and Treatment of Liver Cirrhosis and Associated Syndromes |
| title_short | Innovative Strategies in the Diagnosis and Treatment of Liver Cirrhosis and Associated Syndromes |
| title_sort | innovative strategies in the diagnosis and treatment of liver cirrhosis and associated syndromes |
| topic | liver cirrhosis innovative diagnostics targeted therapies regenerative medicine prognostic scoring |
| url | https://www.mdpi.com/2075-1729/15/5/779 |
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