Protocol for RNA interference in gene expression in adult insects of Triatoma infestans (Hemiptera: Reduviidae)

Summary: RNA interference (RNAi) is a technique that enables post-transcriptional gene silencing in organisms. Here, we present a protocol for silencing the clock gene period (per) in adult insects of Triatoma infestans using RNAi. We describe steps for insect rearing, synthesis of double-stranded R...

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Main Authors: Lourdes E. Córdoba, Alicia R. Pérez de Rosas, Beatriz A. García, María M. Stroppa
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:STAR Protocols
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Online Access:http://www.sciencedirect.com/science/article/pii/S2666166725002710
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author Lourdes E. Córdoba
Alicia R. Pérez de Rosas
Beatriz A. García
María M. Stroppa
author_facet Lourdes E. Córdoba
Alicia R. Pérez de Rosas
Beatriz A. García
María M. Stroppa
author_sort Lourdes E. Córdoba
collection DOAJ
description Summary: RNA interference (RNAi) is a technique that enables post-transcriptional gene silencing in organisms. Here, we present a protocol for silencing the clock gene period (per) in adult insects of Triatoma infestans using RNAi. We describe steps for insect rearing, synthesis of double-stranded RNA (dsRNA) of target genes, and abdominal microinjection with dsRNA. We then detail procedures for collecting and extracting RNA from heads at different time points and evaluating silencing efficiency using quantitative reverse-transcription PCR (RT-qPCR).For complete details on the use and execution of this protocol, please refer to Córdoba et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
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spelling doaj-art-8d7239db6e2448049c8d968f3535fbff2025-08-20T03:55:22ZengElsevierSTAR Protocols2666-16672025-06-016210386510.1016/j.xpro.2025.103865Protocol for RNA interference in gene expression in adult insects of Triatoma infestans (Hemiptera: Reduviidae)Lourdes E. Córdoba0Alicia R. Pérez de Rosas1Beatriz A. García2María M. Stroppa3Instituto de Investigaciones en Ciencias de la Salud (INICSA), CONICET and Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina; Corresponding authorInstituto de Investigaciones en Ciencias de la Salud (INICSA), CONICET and Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, ArgentinaInstituto de Investigaciones en Ciencias de la Salud (INICSA), CONICET and Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, ArgentinaInstituto de Investigaciones en Ciencias de la Salud (INICSA), CONICET and Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina; Corresponding authorSummary: RNA interference (RNAi) is a technique that enables post-transcriptional gene silencing in organisms. Here, we present a protocol for silencing the clock gene period (per) in adult insects of Triatoma infestans using RNAi. We describe steps for insect rearing, synthesis of double-stranded RNA (dsRNA) of target genes, and abdominal microinjection with dsRNA. We then detail procedures for collecting and extracting RNA from heads at different time points and evaluating silencing efficiency using quantitative reverse-transcription PCR (RT-qPCR).For complete details on the use and execution of this protocol, please refer to Córdoba et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.http://www.sciencedirect.com/science/article/pii/S2666166725002710Model OrganismsMolecular BiologySpecial IssueProtocols in Entomology
spellingShingle Lourdes E. Córdoba
Alicia R. Pérez de Rosas
Beatriz A. García
María M. Stroppa
Protocol for RNA interference in gene expression in adult insects of Triatoma infestans (Hemiptera: Reduviidae)
STAR Protocols
Model Organisms
Molecular Biology
Special Issue
Protocols in Entomology
title Protocol for RNA interference in gene expression in adult insects of Triatoma infestans (Hemiptera: Reduviidae)
title_full Protocol for RNA interference in gene expression in adult insects of Triatoma infestans (Hemiptera: Reduviidae)
title_fullStr Protocol for RNA interference in gene expression in adult insects of Triatoma infestans (Hemiptera: Reduviidae)
title_full_unstemmed Protocol for RNA interference in gene expression in adult insects of Triatoma infestans (Hemiptera: Reduviidae)
title_short Protocol for RNA interference in gene expression in adult insects of Triatoma infestans (Hemiptera: Reduviidae)
title_sort protocol for rna interference in gene expression in adult insects of triatoma infestans hemiptera reduviidae
topic Model Organisms
Molecular Biology
Special Issue
Protocols in Entomology
url http://www.sciencedirect.com/science/article/pii/S2666166725002710
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